Hematology - 6th Edition - ISBN: 9781437729283, 9780323246934


6th Edition

Basic Principles and Practice, Expert Consult Premium Edition - Enhanced Online Features and Print

Print ISBN: 9781437729283
eBook ISBN: 9780323246934
Imprint: Churchill Livingstone
Published Date: 19th November 2012
Page Count: 2384


Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options.

Key Features

  • Make confident, effective clinical decisions by consulting the world's most trusted hematology reference.
  • Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more.

Table of Contents

PART I: Molecular and Cellular Basis of Hematology

1 Anatomy and Pathophysiology of the Gene

2 Genomic Approaches to Hematology

3 Regulation of Gene Expression, Transcription, Splicing, and RNA Metabolism

4 Protein Synthesis, Processing, and Trafficking

5 Protein Architecture: Relationship of Form and Function

6 Signaling Transduction and Regulation of Cell Metabolism

7 Pharmacogenomics and Hematologic Diseases

PART II: Cellular Basis of Hematology

8 Hematopoietic Stem Cell Biology

9 Hematopoietic Microenvironment

10 Cell Adhesion

11 Hematopoietic Cell Trafficking and Chemokines

12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization

13 Vascular Growth in Health and Disease

14 Principles of Cytokine Signaling

15 Control of Cell Division

16 Cell Death

PART III: Immunologic Basis of Hematology

17 Overview and Compartmentalization of the Immune System

18 B-Cell Development

19 T-Cell Immunity

20 Natural Killer Cell Immunity

21 Dendritic Cell Biology

22 Complement and Immunoglobulin Biology

23 Tolerance and Autoimmunity

PART IV: Disorders of Hematopoietic Cell Development

24 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation

25 Granulocytopiesis and Monocytopoiesis

26 Thrombocytopoiesis

27 Inherited Forms of Bone Marrow Failure

28 Aplastic Anemia

29 Paroxysmal Nocturnal Hemoglobinuria

30 Acquired Disorders of Red Cell, White Cell, and Platelet Production

PART V: Red Blood Cells

31 Pathobiology of the Human Erythrocyte and Its Hemoglobins

32 Approach to Anemia in the Adult and Child

33 Pathophysiology of Iron Homeostasis



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"This outstanding book will be a great resource to hematologists in practice and in training all over the world. It is current and, with plans for continually supplementing the online version as more information becomes available, it will continue to be up to date."

-Kehinde Adekola, MBBS Northwestern University Feinberg School of Medicine

5 Star - Doody's Rating, March 2013

"There has been a significant improvement in general layout and visual appearence between the 5th and 6th editions. The book is now in full colour throughout, with numerous sections of added and useful information contained in blue and red coloured boxes...The entire text of the book, including downloadable images, is available online, and includes updates to the book - such as the recent addition of arsenic trioxide and ATRA as treatment for acute promyelocytic leukaemia...for the truly discerning haematologist, only th fullest detail will suffice, and only Hoffman's Hematology: Basic Principles and Practice will do."

Haemtrainee, Sept 2013