6th Edition

Basic Principles and Practice, Expert Consult Premium Edition - Enhanced Online Features and Print


  • Ronald Hoffman
  • Edward Benz
  • Leslie Silberstein
  • Helen Heslop
  • Jeffrey Weitz
  • John Anastasi
  • Key Features

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    Table of Contents

    PART I: Molecular and Cellular Basis of Hematology

    1 Anatomy and Pathophysiology of the Gene

    2 Genomic Approaches to Hematology

    3 Regulation of Gene Expression, Transcription, Splicing, and RNA Metabolism

    4 Protein Synthesis, Processing, and Trafficking

    5 Protein Architecture: Relationship of Form and Function

    6 Signaling Transduction and Regulation of Cell Metabolism

    7 Pharmacogenomics and Hematologic Diseases

    PART II: Cellular Basis of Hematology

    8 Hematopoietic Stem Cell Biology

    9 Hematopoietic Microenvironment

    10 Cell Adhesion

    11 Hematopoietic Cell Trafficking and Chemokines

    12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization

    13 Vascular Growth in Health and Disease

    14 Principles of Cytokine Signaling

    15 Control of Cell Division

    16 Cell Death

    PART III: Immunologic Basis of Hematology

    17 Overview and Compartmentalization of the Immune System

    18 B-Cell Development

    19 T-Cell Immunity

    20 Natural Killer Cell Immunity

    21 Dendritic Cell Biology

    22 Complement and Immunoglobulin Biology

    23 Tolerance and Autoimmunity

    PART IV: Disorders of Hematopoietic Cell Development

    24 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation

    25 Granulocytopiesis and Monocytopoiesis

    26 Thrombocytopoiesis

    27 Inherited Forms of Bone Marrow Failure

    28 Aplastic Anemia

    29 Paroxysmal Nocturnal Hemoglobinuria

    30 Acquired Disorders of Red Cell, White Cell, and Platelet Production

    PART V: Red Blood Cells

    31 Pathobiology of the Human Erythrocyte and Its Hemoglobins

    32 Approach to Anemia in the Adult and Child

    33 Pathophysiology of Iron Homeostasis


    No. of pages:
    © 2013
    Churchill Livingstone
    Print ISBN:
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    About the authors

    Ronald Hoffman

    Affiliations and Expertise

    Albert A. and Vera G. List Professor of Medicine, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York

    Edward Benz

    Affiliations and Expertise

    Richard and Susan Smith Professor of Medicine, Professor of Pediatrics and Genetics, Harvard Medical School; President and CEO, Dana-Farber Cancer Institute Director and Principal Investigator Dana Farber/Harvard Cancer Center, Boston, Massachusetts

    Leslie Silberstein

    Affiliations and Expertise

    Professor of Pathology (Pediatrics), Director, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, Massachusetts

    Helen Heslop

    Affiliations and Expertise

    Professor, Departments of Medicine and Pediatrics Section of Hematology-Oncology, Baylor College of Medicine; Dan L. Duncan Chair Director, Adult Stem Cell Transplant Program, The Methodist Hospital; Associate Director Clinical Research, Dan L. Duncan Cancer Center; Houston, Texas

    Jeffrey Weitz

    Affiliations and Expertise

    Professor of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Heart and Stroke Foundation/J.F. Mustard Chair in Cardiovascular Research Canada Research Chair (Tier 1) in Thrombosis, Executive Director, Thrombosis & Atherosclerosis Research Institute (TaARI), Hamilton General Hospital, Hamilton, Ontario, Canada

    John Anastasi

    Affiliations and Expertise

    Associate Professor; Assistant Director, Hematopathology; Medical Director, Flow Cytometry; Department of Pathology, The University of Chicago; Chicago, Illinois