Hedgehog Signaling, Volume 88

1st Edition

Serial Editors: Gerald Litwack
Hardcover ISBN: 9780123946225
eBook ISBN: 9780123948380
Imprint: Academic Press
Published Date: 12th March 2012
Page Count: 584
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Table of Contents

Former Editors



Chapter One: Hedgehog Signaling

I. Hedgehog Ligands

II. Hedgehog Signaling

III. Hedgehog Signaling in Zebrafish Eye Vesicle Patterning

IV. Hedgehog Signaling in Zebrafish Photoreceptor Differentiation

V. Hedgehog Signaling in Zebrafish Inner Nuclear Layer

VI. Hedgehog Signaling in Zebrafish Ganglion Cell Differentiation

Chapter two: Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies

I. Hedgehog Introduction

II. Regulation of Canonical HH Signaling and Its Implication in Cancer

III. SMO-Independent Modulation of GLI Activity

IV. Hedgehog in Hematopoiesis and Hematopoietic Stem Cells

V. From HSC to CML

VI. T- and B-Cell Malignancies

VII. Outlook

Chapter three: Noncanonical Hedgehog Signaling

I. Definition

II. Type I Noncanonical Signaling: Pathways Engaged Exclusively by Ptc1

III. Type II Noncanonical Signaling: Pathways Engaged by Smoothened

IV. Noncanonical Hh Signaling in Drosophila

V. Concluding Remarks

Chapter four: Gli Protein Nuclear Localization Signal

I. Introduction

II. Nuclear Localization Signal and Nuclear Export Signal

III. NLS and NES Mapping

IV. Sequence Comparison of Gli NLSs—NLSs in ZF Domains

V. Predicted 3D Structure of Gli NLS

VI. NLS Control of Gli/Ci Subcellular Localization in Hh Signaling

VII. Perspectives

Chapter five: Mammalian Homologues of Drosophila Fused Kinase

I. Introduction

II. The Major Steps of Hh Signaling

III. Ci/Gli Proteins are Transcription Factors Mediating Hh Activities

IV. Hedgehog Signaling Complex is Responsible for Regulation of ci Protein

V. Regulation of Gli Proteins

VI. Fu is a Protein Kinase Playing Catalytic and Regulatory Roles in ci


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hedgehog signaling.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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About the Serial Editors

Gerald Litwack Serial Editor

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton,

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA