Heart Physiology and Pathophysiology

4th Edition

Editor-in-Chiefs: Nicholas Sperelakis
Editors: Yoshihisa Kurachi Andre Terzic Michael Cohen
Hardcover ISBN: 9780126569759
eBook ISBN: 9780080533889
Imprint: Academic Press
Published Date: 25th September 2000
Page Count: 1261
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Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.

Key Features

@introbul:Key Features @bul:* The most comprehensive book available on this topic

  • Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology
  • Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology
  • Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology


: Cardiologists as well as cell biologists, physiologists, pathologists, biophysicists, molecular geneticists, pharmacologists, neuroscientists, haematologists, microbiologists, and molecular biologists. Biomedical researchers and clinicians are likely to want this comprehensive reference.

Table of Contents

Contributors Foreword Preface Part I Pumping Action and Electrical Activity of the Heart

1. Sequence of Cardiac Activation and Ventricular Mechanics 2. Coronary Circulation and Hemodynamics 3. Neurohumoral Control of Cardiac Function 4. Control of Cardiac Output and its Alterations during Exercise and in Heart Failure 5. Ultrastructure of Cardiac Muscle and Blood Vessels 6. Excitability and Impulse Propagation 7. Electrocardiogram and Cardiac Excitation 8. Gap-Junction Channels and Healing-Over of Injury

Part II Cellular Electrophysiology of Heart and Vascular Smooth Muscle

9. Electrogenesis of the Resting Potential 10. Cardiac Action Potentials 11. Electrophysiology of Vascular Smooth Muscle 12. Sodium Channels 13. Voltage-Dependent Calcium Channels 14. Voltage-Dependent K+ Channels 15. Inwardly-Rectifying K+ Channels in the Heart 16. Voltage and Calcium-Activated K+ Channels of Coronary Smooth Muscle 17. Ion Channels in Vascular Smooth Muscle 18. Cardiac Pacemaker Currents 19. Chloride Channels in Heart 20. Regulation of Cardiac Ion Channels by Phosphorylation, Ca2+, Cytoskeleton, and Stretch


21. Cardiac Na+/K+ Pump 22. Cardiac Na+–Ca2+ Exchanger: Pathophysiology and Pharmacology 23. Na+/H+ Exchanger and pH Regulation 24. Transport in Nucleus 25. Sarcoplasmic Reticulum Ca2+ Transport 26. Calcium Release from Cardiac Sarcoplasmic Reticulum

Part IV Vascular Endothelium

27. Function of Vascular Endothelium 28. Ion Channels in Vascular Endothelium

Part V Excitation–Contraction Coupling and Pharmacomechanical Coupling

29. Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle Cells 30. Mechanisms Regulating Cardiac Myofilament Response to Calcium 31. Vascular Smooth Muscle Contraction

Part VI Metabolism and Energetics 32.


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© Academic Press 2001
Academic Press
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About the Editor-in-Chief

Nicholas Sperelakis

Professor Sperelakis currently is Professor and Chairman Emeritus of Physiology and Biophysics at the College of Medicine at the University of Cincinnati. He is a cell physiologist specializing in cellular electrophysiology. Dr Sperelakis received a B.S. in Chemistry, M.S. in Physiology in 1955, and a Ph.D. in Physiology in 1957, all from the University of Illinois, Urbana. He was also trained in electronics, receiving a certificate from the U.S. Navy & Marine Corps Electronics School in Treasure Island, San Francisco. He served in the U.S. Marine Corps during the Korean War. Dr. Sperelakis is the author/co-author of over 550 scientific articles in journals and books. He has lectured at numerous universities worldwide and at international conferences/symposia. He has also trained many postdoctoral fellows and graduate students, and has been a visiting professor at several foreign universities. Professor Sperelakis has served on a number of journal editorial boards. He is a member of numerous professional societies and has served on the Council for several of them. He has served on the science program advisory committees for various international conferences and has organized several conferences. Dr. Sperelakis was an Established Investigator of the American Heart Association (AHA), Fellow at the Marine Biological Laboratory (Woods Hole), and elected Fellow of the American College of Cardiology (FACC). He received Awards for research excellence from Ohio AHA in 1995 and SW Ohio in 1996. His listings include Who's Who in the World, in America, in Science and Engineering, in Medicine and Healthcare, and in American Education.

Affiliations and Expertise

University of Cincinnati, Ohio, U.S.A.

About the Editor

Yoshihisa Kurachi

Affiliations and Expertise

Graduate School of Medicine, Osaka University, Osaka, Japan

Andre Terzic

Affiliations and Expertise

Mayo Clinic and Foundation, Rochester, Minnesota, U.S.A.

Michael Cohen

Affiliations and Expertise

University of South Alabama, College of Medicine, Mobile, U.S.A.