Heart Failure in the Child and Young Adult

Heart Failure in the Child and Young Adult

From Bench to Bedside

1st Edition - December 5, 2017

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  • Editors: Joseph Rossano, John Jefferies, Anthony Chang, Jeffrey Towbin, Robert Shaddy
  • Paperback ISBN: 9780128023938
  • eBook ISBN: 9780128026137

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Heart Failure in the Child and Young Adult: From Bench to Bedside combines multiple etiologies for pediatric heart failure, including congenital heart disease, cardiomyopathies, infectious diseases and metabolic abnormalities. This comprehensive resource combines research from multiple contributors with current guidelines to bridge the knowledge gap for the recognition and management of heart failure in children. Coverage begins with the basic science of heart failure, then progresses through diagnosis, management, treatment and surgery, finally concluding with advanced special topics, including genetics, self-management and nanomedicine.

Key Features

  • Provides coverage of the basic science of heart failure, its epidemiology and economic aspects, outpatient and inpatient management, and advanced therapies, including mechanical circulatory support and heart transplantation
  • Combines cutting-edge research with current guidelines from the field


Basic science researchers in cardiology and pediatrics, cardiologists, pediatric cardiologists, intensive care physicians, and cardiac surgeons

Table of Contents

  • Section I: Basic Science of Heart Failure

    1. Molecular and Cellular Mechanisms in Heart Failure

    Luisa Mestroni

    2. Cardiovascular Receptors and Signaling in Heart Failure

    Daniel Bernstein

    3. Inflammatory Mediators in Heart Failure

    Kory Lavine and Douglas L. Mann

    4. Mechanisms of Hypertrophy in Heart Failure

    Bernhard Kuhn, Shawn Clark West and Matthew Zinn

    5. Hemodynamic Adaptive Mechanisms in Heart Failure

    Alexander Hussey, Robert Gideon Weintraub and Lucas Eastaugh

    6. Neurohormonal Axis and Natriuretic Peptides in Heart Failure

    Melanie Everitt and Stephanie Jialing Nakano

    7. The Pressure-Volume Relationship in Heart Failure

    Dan Penny

    8. Systolic and Diastolic Dysfunction Mechanisms and Assessment of Systolic vs Diastolic Heart Failure

    Antonio Gabriel Cabrera

    9. The Alveolar-Capillary Interface and Pulmonary Edema

    David Wessel

    10. Echocardiographic Quantitation of Ventricular Function

    Mark Friedberg

    11. Magnetic Resonance Imaging Assessment of Heart Failure

    Michael Taylor

    12. Assessment of Heart Failure by Invasive Methods

    Jonathan Jack Rome and Michael Liam O'Byrne

    Section II: Clinical Diagnosis and Management of Pediatric Heart Failure

    13. Epidemiology and Economic Aspects of Pediatric Heart Failure

    Joseph William Rossano

    14. Clinical Recognition of Congestive Heart Failure in Children

    David Driscoll and Jonathan N. Johnson

    15. Classification of Heart Failure

    Robert D. Ross

    16. Right Ventricular Dysfunction

    Andrew Redington

    17. Pediatric Myocarditis

    Charles Canter and Kathleen Simpson

    18. Dilated Cardiomyopathy

    Kimberly Lin, Shelley Miyamoto and Kurt Schumacher

    19. Clinical Features of Restrictive Cardiomyopathy and Constrictive Pericarditis

    Sue Denfield

    20. Hypertrophic Cardiomyopathy

    Steven D. Colan

    21. Left Ventricular Noncompaction

    Jeffrey A. Towbin

    22. Arrhythmogenic Cardiomyopathies

    Frank Marcus and Julia Indik

    23. Valvular Insufficiency and Heart Failure

    Matthew Schwartz, Andrew C. Glatz and Matthew J. Gillespie

    24. Valvular Stenosis and Heart Failure

    Anne Dipchand and Emilie Jean-St-Michel

    25. Coronary Artery Disease in Children and Young Adults

    James C. Fang and Weining David Xu

    26. Heart Failure in Congenital Heart Disease Including Single Ventricle Circulation

    David Rosenthal

    27. Heart Failure in Adults With Congenital Heart Disease

    Alexander Opotowsky, Heather Ross and Luke Burchill

    28. Dysrhythmias and Ventricular Dysfunction and Heart Failure

    Maully Shah and Jeffrey Kim

    29. Heart Failure in the Fetus

    Edgar Jaeggi and Mary T. Donofrio

    30. Heart Failure in the Neonate

    Matthew J. O'Connor, Thomas Daniel Ryan and Steven James Kindel

    31. Heart Failure in Pediatric Pulmonary Diseases

    Dunbar Ivy

    32. Heart Failure and the Pediatric Cardiorenal Syndrome

    Ahmad Kaddourah and Stuart L. Goldstein

    33. Heart Failure in Pediatric Oncologic Disease

    Steven Lipshultz, Vivian Isabel Franco, Neha Bansal and Jyothsna Akam Venkata

    34. The Failing Cardiovascular System in Sepsis

    Maryam Yasmin Naim

    35. Outpatient Management of Pediatric Heart Failure

    Paul Kantor

    36. Quality of Life and Psychosocial Care in Pediatric Heart Failure

    Ivan Wilmot and Bradley S. Marino

    37. Quality Metrics and Quality Improvement in Pediatric Heart Failure

    Jeffrey Anderson

    38. Nursing Aspects of Heart Failure

    Christine Benhase and Karen Hendricks

    Section III: Medical Treatment for Pediatric Heart Failure

    39. Diuretics and Invasive Fluid Management Strategies

    Jack Price

    40. Inotropic Agents in Heart Failure

    Steven Schwartz

    41. Phosphodiesterase Inhibitors

    Timothy Michael Hoffman

    42. Use of Vasodilators in Heart Failure

    Michael Burch, Jacob Simmonds and Timothy Thiruchelvam

    43. Beta-adrenergic Receptor Blockade

    Robert Shaddy

    44. Low Cardiac Output Syndrome in the Intensive Care Setting

    David Nelson

    45. New Therapeutic Strategies in Heart Failure

    Joseph William Rossano and John Lynn Jefferies

    46. Electrophysiologic Devices in Heart Failure

    Bryan Cannon

    47. Catheter Device Therapy for Heart Failure

    Frank Ing

    Section IV: Cardiac Surgery and Pediatric Heart Failure

    48. Post-Transplant Heart Failure

    Elfriede Pahl, Philip Thrush and Simon Urschel

    49. Surgical Strategies for the Failing Systemic Ventricle

    James Tweddell

    50. Valve Intervention for Valve Failure

    Ziyad Hijazi, Hussam Suradi and Ralf Holzer

    51. General Principles of Mechanical Cardiopulmonary Support

    Angela Lorts, Peter Weardon, Jennifer Conway and Timothy Maul

    52. Short-Term Mechanical Cardiopulmonary Support Devices

    David Luis Simon Morales and Ryan Robert Davies

    53. Decision Making in Ventricular Assist Device Support in Pediatric Patients

    Elizabeth D. Blume and Christina VanderPluym

    54. Long Term Ventricular Assist Devices in Children

    Iki c. Adachi, Sarah Burki and Charles Fraser

    55. The Adult Experience with Long-Term Assist Devices

    William E. Cohn

    56. Future of Mechanical Support Devices in Children and Young Adults

    Robert Jaquiss

    Section V: Special Topics

    57. Genetics and Genomics

    Michael J. Ackerman and Johan Martijn Bos

    58. Genetic Testing

    Ray Hershberger

    59. Data Management and Analytics

    Anthony Chang

    60. Self Management and Outpatient Monitoring

    John Lynn Jefferies, Anthony Chang, Jacob Mathew and Jennifer Lail

    61. Regenerative Medicine and Nanomedicine

    James Willerson

    62. Nanomedicine

    Kevin Maher

    63. Nutritonal Assessment and Mangement in Pediatric Heart Failure

    Chitra Ravishankar

Product details

  • No. of pages: 824
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: December 5, 2017
  • Imprint: Academic Press
  • Paperback ISBN: 9780128023938
  • eBook ISBN: 9780128026137

About the Editors

Joseph Rossano

Dr. Rossano is the medical director of Pediatric Heart Transplant and Heart Failure. He is also an attending physician in the Cardiac Center and the Cardiac Intensive Care Unit (CICU) and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Rossano is principal investigator or co-investigator on several ongoing research studies of the use of ventricular assist devices and artificial hearts in children, studying the effectiveness of post-transplant treatments for children who have received heart transplants, an observational study of children with heart failure, and building a registry of pediatric heart transplant patients that aims to further the knowledge of pediatric heart disease and transplantation.

Affiliations and Expertise

Executive Director, The Cardiac Center, Medical Director, Heart Failure and Transplantation, Associate Professor of Pediatrics, The Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, USA

John Jefferies

John Jefferies
Dr. Jefferies is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.

Affiliations and Expertise

Cincinnati Children’s Hospital, OH, USA

Anthony Chang

Dr. Chang is internationally-recognized as an expert in the field of pediatric cardiology. He is one of the founding members of the Asia-Pacific Pediatric Cardiac Society (APPCS) and will be initiating the foundation arm of the society at the bequest of the board. Dr. Chang has been voted “Physician of Excellence” by the Orange County Medical Association and also selected as one of America’s “Top Doctors,” “Top Pediatricians,” and “Best Cardiologists” by several organizations. He is a member of the grant review committee for pediatric research at the National Institutes of Health; and board of directors for the American Heart Association.

Affiliations and Expertise

Chief Intelligence and Innovation Officer, Medical Director, The Sharon Disney Lund Medical Intelligence and Innovation Institute (MI3), Children's Hospital of Orange County, USA

Jeffrey Towbin

Jeffrey Towbin
Dr. Towbin is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.

Affiliations and Expertise

Cincinnati Children’s Hospital, OH, USA

Robert Shaddy

Dr. Shaddy is Chief of the Division of Cardiology at The Children’s Hospital of Philadelphia and holds the Jennifer Terker Endowed Chair in Pediatric Cardiology. He is Professor of Pediatrics and Vice Chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Shaddy brings more than 25 years of experience as a cardiologist caring for children with heart failure to his role as one of the leaders of the transplant program.

Affiliations and Expertise

Chief of the Division of Cardiology, Jennifer Terker Endowed Chair in Pediatric Cardiology at CHOP

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