Heart Development - 1st Edition - ISBN: 9780123298607, 9780080533872

Heart Development

1st Edition

Editors: Richard Harvey Nadia Rosenthal
Hardcover ISBN: 9780123298607
eBook ISBN: 9780080533872
Imprint: Academic Press
Published Date: 23rd October 1998
Page Count: 530


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This book examines recent studies revealing that the same genes are responsible for development of parallel features between species, and that the heart develops similarly across all species. It includes research being conducted concerning cardiac development, tissue interaction, and organ formation. The text attempts to provide a greater understanding of the underlying causes of heart failure, heart muscle diseases, congenital malformations, and other heart diseases and defects.

Key Features

@introbul:Key Features @bul:* Each chapter has been solicited from a recognized leader in the field, and covers a topic of active research in cardiovascular biology

  • Chapters incorporate a review of classical findings with comprehensive coverage of the latest advances
  • Abundant color plates in a consistent and professional artistic style provide clear and attractive illustrations of central concepts
  • Color slides of illustrations for seminars or teaching purposes are available with each volume


Graduate students, post-docs, and researchers in cell biology, developmental biology, genetics, molecular biology, and hematology.

Table of Contents

Contributors. Preface.

C. Seidman, Introduction.

I. Origins and Early Morphogenesis:

P.P.L. Tam and G.C. Schoenwolf, Cardiac Fate Maps: Lineage Allocation, Morphogenetic Movement, and Cell Commitment.

T. Mikawa, Cardiac Lineages.

II. Cardiac Induction:

T.J. Mohun and L.M. Leong, Heart Formation and the Heart Field in Amphibian Embryos.

T.M. Schultheiss and A.B. Lassar, Vertebrate Heart Induction.

III. Genetic Dissection of Heart Development:

R. Bodmer and M. Frasch, Genetic Determination in Drosophilia Heart Development.

J. Alexander and D.Y.R. Stainier, Mutations Affecting Cardiac Development in Zebrafish.

R.P. Harvey, C. Biben, and D.A. Elliott, Transcriptional Control and Pattern Formation in the Developing Vertebrate Heart: Studies on NK-2 Class Homeodomain Factors.

B.L. Black and E.N. Olson, Control of Cardiac Development by the Family of MEF2 Transcription Factors.

D. Srivastava, Segmental Regulation of Cardiac Development by the Basic Helix-Loop-Helix Transcription Factors dHAND and eHAND.

IV. Normal and Abnormal Morphogenesis:

C.H. Mjaatvedt, H. Yamamura, A. Wessels, A. Ramsdell, D. Turner, and R.R. Markwald, Mechanisms of Segmentation, Septation and Remodeling of the Tubular Heart: Endocardial Cusion and Cardiac Looping.

M.L. Kirby, Contribution of Neural Crest to Heart and Vessel Morphology.

A.F.M. Moorman and W.H. Lamars, Development of the Conduction System of the Vertebrate Heart.

S.W. Kubalak and H.M. Sucov, Retinoids in Heart Development.

O. Cleaver and P.A. Krieg, Molecular Mechanisms of Vascular Development.

V. Genetic Control of Muscle Gene Expression:

V.T.B. Nguyêñ-Trân, J. Chen, P. Ruiz-Lozano, and K.R. Chien, The MLC-2 Paradigm for Ventricular Heart Chamber Specification, Maturation, and Morphogenesis.

J.M. Reecy, N.S. Beelaguli, and R.J. Schwartz, Serum Response Factor-NK Homeodomain Factor Interactions, Role in Cardiac Development.

M.S. Parmacek and J.M. Leiden, GATA Transcription Factors and Cardiac Development.

S.B. Larkin and C.P. Ordahl, Multiple Layers of Control in Transcriptional Regulation by MCAT Elements and the TEF-1 Protein Family.

VI. Heart Patterning: The Anterior/Posterior Axis:

R.G. Kelly, D. Franco, A.F.M. Moorman, and M. Buckingham, Regionalization of Transcriptional Potential in the Myocardium.

G.F. Wang and F.E. Stockdale, Chamber-Specific Gene Expression and Regulation During Heart Development.

VII. Heart Patterning: Left-Right Asymmetry:

H.J. Yost, Establishing of Cardiac Left-Right Asymmetry.

K. Majurnder and P.A. Overbeek, Left-Right Asymmetry and Cardiac Looping.

VIII. Cell Proliferation in Cardiovascular Development and Disease:

W.R. MacLellan and M.D. Schneider, The Cardiac Cell Cycle.

K. Walsh, H.R. Perlman, and R.C. Smith, Regulation of Vascular Smooth Muscle Differentiation and Cell Cycle.

IX. Human Cardiac Developmental Defects:

N.A. Brown and R.H. Anderson, Symmetry and Laterality in the Human Heart: Developmental Implications.

B.S. Emanuel, M.L. Budarf, and P.J. Scambler, The Genetic Basis of Conotruncal Cardiac Defects: The Chromosome 22q.11.2 Deletion.

B. Casey and K. Kosaki, Genetics of Human Left-Right Axis Malformations.

X. Lessons from Skeletal Muscle:

M. McGrew, J. Xavier-Neto, O. Pourquie, and N. Rosenthal, Molecular Genetics of Skeletal Muscle Development. Index.


No. of pages:
© Academic Press 1999
Academic Press
eBook ISBN:

About the Editor

Richard Harvey

Affiliations and Expertise

Victor Chang Cardiac Research Institute, Sydney, Australia

Nadia Rosenthal

Affiliations and Expertise

European Molecular Biology Laboratory, Monterotondo (Rome), Italy


"The book is quite complete in scope... The numerous illustrations are remarkably well crafted, even gorgeous. The attention so obviously devoted by the authors and editors to these explanatory illustrations is esthetically rewarding and will be particularly valuable to readers with little background in developmental biology...Serious scholars and investigators in the field will want this book because it is the mose accessible, authoritative, and complete summary of cardiac development currently available, one that can serve as a reference for themselves, their students, and their laboratory personnel...the sheer beauty of the book, the usefulness of the index, and the clarity of the illustrations should provide both information and pleasure to a broad readership." @source:--NEW ENGLAND JOURNAL OF MEDICINE (April 1999) @qu:"Heart Development is therefore timely and important, and fills a void in the available literature... Often such volumes are so long in the making that they are out of date before they are published. Not this book. With up-to-date chapters written by many recognized authorities in the field of cardiac development, and clear, high quality illustrations (a particularly strong feature), the book will be valuable to graduate students, investigators in the basic sciences, and clinicians wishing to stay current in this field." @source:--NATURE MEDICINE (March 1999) @qu:"The 28 chapters in Heart Development are very well written. The book is beautifully produced and contains many excellent diagrams... The volume is indispensable for those who work on the heart..." @source:--SCIENCE (February 1999)