Traumatic Brain Injury, Part I, Volume 127

1st Edition

Editors: Jordan Grafman Andres Salazar
Hardcover ISBN: 9780444528926
eBook ISBN: 9780444634986
Imprint: Elsevier
Published Date: 1st February 2015
Page Count: 490
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Table of Contents

  • Handbook of Clinical Neurology 3rd Series
  • Foreword
  • Preface
  • SECTION 1: Risk and predisposition

    • Chapter 1: Epidemiology of traumatic brain injury

      • Abstract
      • Overview: importance of injury and traumatic brain injury
      • Overall traumatic brain injury rates
      • Definitions
      • Cost: burden of injury
      • Severity measures
      • Emergency department rates
      • Hospitalizations
      • Deaths
      • Mechanism (external causes)
      • Peaks within age groups
      • Gender
      • Race
      • Traumatic brain injury in the military
      • Disability
      • Alzheimer's disease and epilepsy
      • Rehabilitation
      • Conclusions
      • Disclaimer
    • Chapter 2: Classification of traumatic brain injury: past, present, and future

      • Abstract
      • Introduction
      • History of and approaches to disease classification
      • An ideal classification system
      • Classifying traumatic brain injury
      • The future of traumatic brain injury classification
      • Conclusion
    • Chapter 3: Genetic predictors of outcome following traumatic brain injury

      • Abstract
      • Traumatic brain injury is a chronic debilitating condition
      • State of genomics research on traumatic brain injury
      • Goals
      • Candidate gene approaches
      • Candidate gene targets
      • Going beyond candidate gene association studies
      • Future directions
      • Conclusions
  • SECTION 2: Pathology and mechanisms of traumatic brain injury

    • Chapter 4: The neuropathology of traumatic brain injury

      • Abstract
      • Introduction
      • Acute moderate-severe traumatic brain injury
      • Acute mild traumatic brain injury
      • Chronic effects of traumatic brain injury
      • Future areas for research
      • Conclusions
      • Acknowledgments
    • Chapter 5: C


The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI.

Key Features

  • Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injury
  • Explores cellular and molecular mechanisms as well as genetic predictors of outcome
  • Offers coverage of various diagnostic tools – CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and more
  • State-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care


Neurologists and neuroscientists


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About the Editors

Jordan Grafman Editor

Jordan Grafman, PhD, is director of Brain Injury Research at the Rehabilitation Institute of Chicago. Before joining RIC, Dr. Grafman was director of the Traumatic Brain Injury Research at Kessler Foundation. His investigation of brain function and behavior contributes to advances in medicine, rehabilitation, and psychology, and informs ethics, law, philosophy, and health policy. His study of the human prefrontal cortex and cognitive neuroplasticity incorporates neuroimaging and genetics, an approach that is expanding our knowledge of the impact of traumatic brain injury, as well as other diseases that impair brain function, such as stroke, multiple sclerosis and degenerative diseases. Dr. Grafman aims to translate his research into more effective, targeted rehabilitation to achieve the best outcomes for people with cognitive disabilities. Dr. Grafman’s background includes 30 years of experience in brain injury research. He has studied brain function in dementia, depression, and degenerative neurological diseases, as well as TBI. He has authored more than 300 research publications, co-editor of the journal Cortex, and provides peer review for numerous specialty journals. At the National Institutes of Health, he served as chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke. While in the US Air Force, he served at Walter Reed Army Medical Center as neuropsychology chief of the Vietnam Head Injury Project, a long-term study of more than 500 soldiers with serious injuries of the head and brain. He is the leading expert on the long-term effects of penetrating brain injuries in military personnel. His expertise includes the scope of challenges faced during recovery, including behavioral changes like aggression, late sequelae such as seizures, and the impact on TBI on family life and employment, and legal implications. He is an elected fellow of the American Psychological Association and the New York Academy of Scie

Affiliations and Expertise

Northwestern University Medical School and Department of Psychology, Northwestern University, Chicago, IL, USA

Andres Salazar Editor

Andres M. Salazar, MD, is CEO, Scientific Director and cofounder of Oncovir, Inc., a pharmaceutical company developing the immunomodulator, Hiltonol® (Poly-ICLC). He is a retired US Army Colonel and formerly Professor of Neurology at USUHS. He was Director of the Vietnam Head Injury Study and Founder, Principal Investigator, and first Director of the Defense and Veterans Head Injury Program, an ongoing U.S. National Head Injury clinical management and research effort. His research background includes neurotraumatology, neurodegenerative diseases, multiple sclerosis (MS), AIDS, and Oncology. He has over 200 publications, several patents, and has conducted multiple clinical studies, including in head injury, AIDS, pilot and pivotal clinical trials of beta-interferon (Avonex) in multiple sclerosis, and clinical trials of Hiltonol® in various cancers, MS, and AIDS. Dr. Salazar is a graduate of Dartmouth College and Jefferson Medical College. He completed Neurology training at Walter Reed Army Medical Center, and a Neurovirology Fellowship at the CNSSL, National Institutes of Health, Bethesda, MD.

Affiliations and Expertise

Chairman, CEO, & Scientific Director, Oncovir, Inc., Washington, DC, USA