Hazard Assessment of Chemicals

Hazard Assessment of Chemicals

Current Developments

1st Edition - April 28, 1983

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  • Editor: Jitendra Saxena
  • eBook ISBN: 9781483261898

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Hazard Assessment of Chemicals: Current Developments, Volume 2 contains authoritative articles, which provide a comprehensive review and evaluation of important information on chemical spills, and presents case studies that show the applications of methods and approaches to environmental and health hazard assessment of chemicals. The book is comprised of five subject reviews and two case studies of chemical spills. Experts tackle subjects on the use of simulation models to determine pollutant behavior and pollutant migration; use of microcosms to assess chemical effects on the properties of aquatic ecosystems; and metabolism and disposition of potentially hazardous chemicals in maternal-embryonic/fetal systems. Epidemiological approaches to chemical hazard assessment and a review of The National Toxicology Program (NTP) in the Department of Health and Human Services are also presented. Environmentalists, ecologists, toxicologists, public safety officers and workers, and those concerned with the health effects of chemical agents in the environment will find this text invaluable.

Table of Contents

  • Contents



    Contents of Volume 1

    Use of Models for Assessing Relative Volatility, Mobility, and Persistence of Pesticides and Other Trace Organics in Soil Systems

    I. Introduction

    II. Pathways of Pesticide Loss in Soil

    III. Benchmark Properties Needed to Predict Pesticide Loss from Soils

    IV. Theory

    V. Chemicals and Properties Used in Screening Tests

    VI. Results of Screening Tests

    VII. Discussion

    VIII. Limitations of Screening Model

    IX. Application to Other Chemicals

    X. Summary and Conclusions

    List of Symbols


    Microcosms for Assessment of Chemical Effects on the Properties of Aquatic Ecosystems

    I. Introduction

    II. Measurements of Aquatic Ecosystem Properties

    III. Mixed-Culture Microcosms

    IV. Pond Microcosms

    V Pelagic Microcosms

    VI. Discussion


    Disposition of Chemical Contaminants in Maternal-Embryonic/Fetal Systems

    I. Introduction

    II. Entrance of Chemicals into Maternal Circulatory Fluids

    III. Transfer of Chemicals from Maternal Circulatory Fluids to Other Maternal Tissues and Organs

    IV Elimination of Chemicals from the Maternal Organism

    V Factors Affecting Transfer of Chemicals from Maternal Plasma to Embryonic/Fetal Tissues

    VI. Disposition of Chemicals in the Embryo and Fetus

    VII. Summary and Conclusions


    Epidemiologic Approaches to Chemical Hazard Assessment

    I. Introduction

    II. Developing Clues to Chemically Related Disease: Descriptive Approaches

    III. Testing Etiologic Hypotheses: An Overview of Analytic Approaches

    IV Crucial Aspects of Environmental Study Design

    V Relating Measures of Dose to Measures of Response

    VI. Conclusion


    The National Toxicology Program's Research and Testing Activities

    I. Introduction

    II. Program Components and Resources

    III. Oversight and Review

    IV. Program Organization and Management

    V Toxicology Research and Testing

    VI. Chemical Nomination and Chemical Selection

    VII. Information Generation and Dissemination

    VIII. Future Directions

    Selected References

    Accidental Release of Vinyl Chloride: The Train Derailment near MacGregor, Manitoba

    I. Introduction

    II. Chronology of the Accident

    III. Sequence of Events. Analysis Based on the Physical/Chemical Properties of Vinyl Chloride

    IV Vinyl Chloride Toxicity

    V Analysis of Vinyl Chloride

    VI. Guidelines Concerning Instructions for Action in the Event of an Accident

    VII. Guidelines Concerning Communications in the Event of an Accident

    VIII. Conclusion


    Anatomy of a TCDD Spill: The Seveso Accident

    I. Introduction

    II. Chronology of the Accident

    III. Cause of the Accident

    IV Evidence of TCDD Contamination and Assessment of the Risk to Humans

    V Medical Surveillance of the Exposed Population

    VI. Rehabilitation of the Damaged Area

    VII. Compensation for Damage to Environment and Property

    VIII. Postaccident Analyses


    Chemical Substance Index

    Subject Index

Product details

  • No. of pages: 376
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: April 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9781483261898

About the Editor

Jitendra Saxena

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