Haschek and Rousseaux's Handbook of Toxicologic Pathology - 3rd Edition - ISBN: 9780124157590, 9780124157651

Haschek and Rousseaux's Handbook of Toxicologic Pathology

3rd Edition

Editors: Wanda Haschek Colin Rousseaux Matthew Wallig
Hardcover ISBN: 9780124157590
eBook ISBN: 9780124157651
Imprint: Academic Press
Published Date: 17th June 2013
Page Count: 3054
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Institutional Access


Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.

Key Features

  • Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations


Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories.

Table of Contents

Volume 1: General Toxicologic Pathology

Preface. Contributors.

Part A: Basics of Toxicologic Pathology Toxicologic Pathology: An Introduction. Biochemical Basis of Toxicity. Morphologic Manifestation of Toxic Cell Injury. Organelle Biochemistry and Regulation of Cell Death. Carcinogenesis. Applied Clinical Pathology in Preclinical Toxicology Testing. Nomenclature. Part B: The Practice of Toxicologic Pathology Basic Techniques. Managing Pitfalls in Toxicologic Pathology. Special Techniques in Toxicologic Pathology. Application of New Technologies to Toxicologic Pathology. Issues in Laboratory Animal Science for the Toxicologic Pathologist. New Animal Models in Toxicology. Pathology Issues in the Design of Toxicology Studies. Use and Misuse of Statistics in the Design and Interpretation of Studies. Preparation of the Report for a Toxicology/Pathology Study. Part C: Selected Topics in Toxicologic Pathology Risk Assessment: The Changing Paradigm. Principles of Risk Communication: Building Trust and Credibility with the Public. Biomedical Devices and Biomaterials. Biotechnology and Its Products. Endocrine Disruptors. Radiation and Heat. Nutritional Toxicologic Pathology. Phycotoxins. Mycotoxins. Heavy Metals. Volume 2: Organ Specific Toxicologic Pathology

Organ-Specific Toxicologic Pathology: An Introduction. Respiratory System. Skin and Oral Mucosa. Gastrointestinal Tract. Liver. Pancreas. Kidney. Lower Urinary Tract. Cardiovascular and Skeletal Muscle Systems. Bones and Joints. Nervous System. The Eye. Immune System. Hematopoietic System. Endocrine System. Male Reproduction. Female Reproduction. Embryo and Fetus.



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© Academic Press 2013
Academic Press
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About the Editor

Wanda Haschek

Affiliations and Expertise

University of Illinois at Urbana-Champaign

Colin Rousseaux

Affiliations and Expertise

University of Ottawa

Matthew Wallig

Affiliations and Expertise

University of Illinois at Urbana-Champaign


"…the long awaited third edition of this well-respected and essential contributor to toxicological pathology, toxicology and other biological and medical disciplines has been published. It is now presented in three volumes instead of two, and benefits tremendously from having colour illustrations throughout. It is straight forward to read and is laid out in a logical format."--btsNews, June 2014
"..this is the most comprehensive textbook yet published covering the various aspects of toxicological pathology in general, and it does a fair job in covering toxicology topics as well. Its scope and breadth of coverage will find it well placed within any toxicology laboratory and I cannot recommend it more highly. It should take pride of place in the library of any toxicology laboratory and should be an indispensable text for pathologists and toxicologists…"--Toxicologic Pathology, January 31, 2014
"Occasionally, a book becomes available that sets a new standard for a subspecialty, and such is the case for the third Edition…This substantially sized…and exceptionally compiled and useful book gathers extensive knowledge from the field of toxicologic pathology as well as tangential and integrative areas…the third edition of this handbook lends itself to being a reference book that reads like an accessible and helpful textbook."--Veterinary Pathology, Vol 51(1), 2014
"The 3 volumes are well organized, and the editors have endeavored to provide clearer and more complete content description for chapter titles that will be easier for nonpathologist to recognize.…This…handbook belongs on the physical- or e-shelf of practitioners of toxicologic pathology and toxicology and needs to be in the communal library of a broad range of individuals in life sciences who interact with toxicologic pathologists."--International Journal of Toxicology, December 2, 2013
"The 2 volumes are excellent companions that complement each other as a "1,2" punch! This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."--VETERINARY AND HUMAN TOXICOLOGY (October 2002)
"...gives an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional."--Paul Baldrick for THE BRITISH TOXICOLOGY SOCIETY NEWSLETTER (Spring 2002)
"...very readable, well-referenced, and current... an excellent book for research training."--DOODY'S