Haschek and Rousseaux's Handbook of Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.

• Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings
• Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
• Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories.

Volume 1: General Toxicologic Pathology

Preface. Contributors.

Part A: Basics of Toxicologic Pathology Toxicologic Pathology: An Introduction. Biochemical Basis of Toxicity. Morphologic Manifestation of Toxic Cell Injury. Organelle Biochemistry and Regulation of Cell Death. Carcinogenesis. Applied Clinical Pathology in Preclinical Toxicology Testing. Nomenclature.

Part B: The Practice of Toxicologic Pathology Basic Techniques. Managing Pitfalls in Toxicologic Pathology. Special Techniques in Toxicologic Pathology. Application of New Technologies to Toxicologic Pathology. Issues in Laboratory Animal Science for the Toxicologic Pathologist. New Animal Models in Toxicology. Pathology Issues in the Design of Toxicology Studies. Use and Misuse of Statistics in the Design and Interpretation of Studies. Preparation of the Report for a Toxicology/Pathology Study.

Part C: Selected Topics in Toxicologic Pathology Risk Assessment: The Changing Paradigm. Principles of Risk Communication: Building Trust and Credibility with the Public. Biomedical Devices and Biomaterials. Biotechnology and Its Products. Endocrine Disruptors. Radiation and Heat. Nutritional Toxicologic Pathology. Phycotoxins. Mycotoxins. Heavy Metals.

Volume 2: Organ Specific Toxicologic Pathology

Organ-Specific Toxicologic Pathology: An Introduction. Respiratory System. Skin and Oral Mucosa. Gastrointestinal Tract. Liver. Pancreas. Kidney. Lower Urinary Tract. Cardiovascular and Skeletal Muscle Systems. Bones and Joints. Nervous System. The Eye. Immune System. Hematopoietic System. Endocrine System. Male Reproduction. Female Reproduction. Embryo and Fetus.

Index.