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Haschek and Rousseaux's Handbook of Toxicologic Pathology - 3rd Edition - ISBN: 9780124157590, 9780124157651

Haschek and Rousseaux's Handbook of Toxicologic Pathology

3rd Edition

Editors: Brad Bolon Wanda Haschek Ricardo Ochoa Colin Rousseaux Matthew Wallig
Hardcover ISBN: 9780124157590
eBook ISBN: 9780124157651
Imprint: Academic Press
Published Date: 1st May 2013
Page Count: 3054
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Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.

Key Features

  • Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations


Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories.

Table of Contents

Volume 1: General Toxicologic Pathology


Part A: Basics of Toxicologic Pathology
Toxicologic Pathology: An Introduction.
Biochemical Basis of Toxicity.
Morphologic Manifestation of Toxic Cell Injury.
Organelle Biochemistry and Regulation of Cell Death.
Applied Clinical Pathology in Preclinical Toxicology Testing.

Part B: The Practice of Toxicologic Pathology
Basic Techniques.
Managing Pitfalls in Toxicologic Pathology.
Special Techniques in Toxicologic Pathology.
Application of New Technologies to Toxicologic Pathology.
Issues in Laboratory Animal Science for the Toxicologic Pathologist.
New Animal Models in Toxicology.
Pathology Issues in the Design of Toxicology Studies.
Use and Misuse of Statistics in the Design and Interpretation of Studies.
Preparation of the Report for a Toxicology/Pathology Study.

Part C: Selected Topics in Toxicologic Pathology
Risk Assessment: The Changing Paradigm.
Principles of Risk Communication: Building Trust and Credibility with the Public.
Biomedical Devices and Biomaterials.
Biotechnology and Its Products.
Endocrine Disruptors.
Radiation and Heat.
Nutritional Toxicologic Pathology.
Heavy Metals.

Volume 2: Organ Specific Toxicologic Pathology

Organ-Specific Toxicologic Pathology: An Introduction.
Respiratory System.
Skin and Oral Mucosa.
Gastrointestinal Tract.
Lower Urinary Tract.
Cardiovascular and Skeletal Muscle Systems.
Bones and Joints.
Nervous System.
The Eye.
Immune System.
Hematopoietic System.
Endocrine System.
Male Reproduction.
Female Reproduction.
Embryo and Fetus.



No. of pages:
© Academic Press 2013
1st May 2013
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

Brad Bolon

Brad Bolon, DVM, MS, PhD, DACVP, DABT, FATS, FIATP, President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA During a 25-year career, Dr. Bolon has been employed in academia, contract research organizations, and two pharmaceutical firms before launching an experimental and toxicologic pathology practice. His main professional interests include comparative pathology of genetically engineered animals and toxicologic neuropathology. He is a past president of the Society of Toxicologic Pathology and is a recipient of the 2018 British Society of Toxicological Pathology’s Gopinath Lecture Award for excellence in toxicologic pathology.

Affiliations and Expertise

President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA

Wanda Haschek

Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011. -Diplomate of the American College of Veterinary Pathologists (ACVP) -Diplomate of the American Board of Toxicology (ABT) -Fellow of the International Academy of Toxicologic Pathologists (FIATP)

Affiliations and Expertise

University of Illinois at Urbana-Champaign

Ricardo Ochoa

Affiliations and Expertise

Pre-Clinical Safety Inc.

Colin Rousseaux

Professor Rousseaux, BVSc [Hons], PhD, DABT, FRCPath, FIATP, FATS is a Fellow of the Royal College of Pathology, Diplomate of the American Board of Toxicology, Fellow of the Academy of Toxicological Sciences, and Fellow of the International Academy of Toxicologic Pathology. He is Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceutical, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former president of the Society of Toxicologic Pathology.

Affiliations and Expertise

Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa, Principal, Colin Rousseaux and Associates, Canada

Matthew Wallig

Professor Wallig, DVM, PhD, DACVP is a Diplomate of the American College of Veterinary Pathologists. He is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables and soy, and the pathophysiology of pancreatic injury.

Affiliations and Expertise

Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA


"…the long awaited third edition of this well-respected and essential contributor to toxicological pathology, toxicology and other biological and medical disciplines has been published. It is now presented in three volumes instead of two, and benefits tremendously from having colour illustrations throughout. It is straight forward to read and is laid out in a logical format."--btsNews, June 2014
"..this is the most comprehensive textbook yet published covering the various aspects of toxicological pathology in general, and it does a fair job in covering toxicology topics as well. Its scope and breadth of coverage will find it well placed within any toxicology laboratory and I cannot recommend it more highly. It should take pride of place in the library of any toxicology laboratory and should be an indispensable text for pathologists and toxicologists…"--Toxicologic Pathology, January 31, 2014
"Occasionally, a book becomes available that sets a new standard for a subspecialty, and such is the case for the third Edition…This substantially sized…and exceptionally compiled and useful book gathers extensive knowledge from the field of toxicologic pathology as well as tangential and integrative areas…the third edition of this handbook lends itself to being a reference book that reads like an accessible and helpful textbook."--Veterinary Pathology, Vol 51(1), 2014
"The 3 volumes are well organized, and the editors have endeavored to provide clearer and more complete content description for chapter titles that will be easier for nonpathologist to recognize.…This…handbook belongs on the physical- or e-shelf of practitioners of toxicologic pathology and toxicology and needs to be in the communal library of a broad range of individuals in life sciences who interact with toxicologic pathologists."--International Journal of Toxicology, December 2, 2013
"The 2 volumes are excellent companions that complement each other as a "1,2" punch! This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."--VETERINARY AND HUMAN TOXICOLOGY (October 2002)
" an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional."--Paul Baldrick for THE BRITISH TOXICOLOGY SOCIETY NEWSLETTER (Spring 2002)
"...very readable, well-referenced, and current... an excellent book for research training."--DOODY'S

Ratings and Reviews