Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Safety Assessment Environmental Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2: Safety Assessment Environmental Toxicologic Pathology

4th Edition - August 1, 2022

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  • Editors: Wanda Haschek, Colin Rousseaux, Matthew Wallig, Brad Bolon
  • Hardcover ISBN: 9780128210475

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Description

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Other volumes in this work round out the depth and breadth of coverage. Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. 

Key Features

  • Provides new chapters on gene therapy, stem cells, regenerative medicine, genome editing, and in-depth discussions of timely topics in toxicologic pathology
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Readership

Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories; regulatory agencies and universities

Table of Contents

  • PART 1: Toxicologic Pathology in Product Discovery and Safety Assessment
    1. Overview of Drug Development
    2. Overview of the Role of Pathology in Product Discovery and Safety Assessment
    3. Discovery Toxicology and Pathology
    4. Pathology in Non-Clinical Drug Safety Assessment
    5. Biopharmaceuticals
    6. Biomedical Materials and Devices
    7. Carcinogenicity Assessment

    PART 2: Safety Assessment and Data Interpretation
    8.  Preparation of the Pathology Report for a Toxicology Study
    9. Interpretation of Clinical Pathology Results in Non-Clinical Toxicology Testing
    10. Statistical Assessment of Toxicologic Pathology Studies
    11. Risk Assessment
    12. Risk Communication for Toxicologic Pathologists
    13. Risk Management in Non-Clinical Drug Development

    PART 3: Food and the Environment: Selected Toxic Agents
    14. Environmental Toxicologic Pathology and Human Health
    15. Food and Toxicologic Pathology: An Overview
    16. Nutritional Toxicologic Pathology
    17. Endocrine Disruptors
    18. Phycotoxins
    19. Mycotoxins
    20. Selected Poisonous Plants Affecting Animal and Human Health
    21. Heavy Metals
    22. Agricultural Chemicals
    23. Nanoparticulates
    24. Radiation and Other Physical Agents

Product details

  • No. of pages: 950
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: August 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128210475

About the Editors

Wanda Haschek

Wanda M Haschek-Hock, BVSc, PhD, DACVP, FIATP, ‎Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011.

Affiliations and Expertise

‎Professor Emerita, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Colin Rousseaux

Professor Rousseaux, BVSc [Hons], PhD, DABT, FRCPath, FIATP, FATS is a Fellow of the Royal College of Pathology, Diplomate of the American Board of Toxicology, Fellow of the Academy of Toxicological Sciences, and Fellow of the International Academy of Toxicologic Pathology. He is Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceutical, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former president of the Society of Toxicologic Pathology.

Affiliations and Expertise

Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa, Principal, Colin Rousseaux and Associates, Canada

Matthew Wallig

Professor Wallig, DVM, PhD, DACVP is a Diplomate of the American College of Veterinary Pathologists. He is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables and soy, and the pathophysiology of pancreatic injury.

Affiliations and Expertise

Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Brad Bolon

Brad Bolon, DVM, MS, PhD, DACVP, DABT, FATS, FIATP, President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA During a 25-year career, Dr. Bolon has been employed in academia, contract research organizations, and two pharmaceutical firms before launching an experimental and toxicologic pathology practice. His main professional interests include comparative pathology of genetically engineered animals and toxicologic neuropathology. He is a past president of the Society of Toxicologic Pathology and is a recipient of the 2018 British Society of Toxicological Pathology’s Gopinath Lecture Award for excellence in toxicologic pathology.

Affiliations and Expertise

President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA

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