Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2

Toxicologic Pathology in Safety Assessment

4th Edition - February 1, 2023

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  • Editors: Wanda M. Haschek-Hock, Colin Rousseaux, Matthew Wallig, Brad Bolon
  • Hardcover ISBN: 9780128210475

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Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety.

Key Features

  • Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field
  • New chapters consider fundamental attributes for additional product classes including protein therapeutics, nucleic acid pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, vaccines, agricultural and bulk chemicals, and assigning adversity
  • Chapters dealing with product-specific practices address pathology and regulatory issues
  • Chapters offer high-quality and up-to-date content in a trusted work written by the collaborative efforts of many leading international subject matter experts
  • Hundreds of full-color images and diagrams are featured in both the print and electronic versions of this book to illustrate classic examples and highlight difficult concepts


Scientists, including pathologists, toxicologists and graduate students, in academia, industry and government. Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories; regulatory agencies and universities

Table of Contents

  • Part 1. Product Discovery and Development
    1. Overview of Drug Development
    2. Overview of the Role of Pathology in Product Discovery and Development
    3. Discovery Toxicology and Discovery Pathology
    4. Pathology in Nonclinical Drug Safety Assessment
    5. Carcinogenicity Assessment

    Part 2. Product-Specific Practices for Safety Assessment
    6. Protein Therapeutics
    7. Nucleic Acid Pharmaceutical Agents
    8. Gene Therapy and Gene Editing
    9. Vaccines
    10. Stem Cell and Other Cell Therapies
    11. Biomedical Materials and Devices
    12. Agricultural and Bulk Chemicals

    Part 3: Data Interpretation and Communication
    13. Preparation of the Anatomic Pathology Report for Toxicity Studies
    14. Interpretation of Clinical Pathology Results in Nonclinical Toxicity Testing
    15. Assigning Adversity to Toxicologic Outcomes
    16. Risk Assessment
    17. Risk Management and Communication: Building Trust and Credibility with the Public

Product details

  • No. of pages: 950
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: February 1, 2023
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128210475

About the Editors

Wanda M. Haschek-Hock

Professor Haschek-Hock has served as president of the Society of Toxicologic Pathology and the Society of Toxicology’s Comparative and Veterinary Specialty Section, as well as Councilor of the American College of Veterinary Pathologists, board member of the American Board of Toxicology; as Associate Editor for Toxicological Sciences and for Toxicologic Pathology; as Editorial Board member for Fundamental and Applied Toxicology, Veterinary Pathology and Toxicologic Pathology. She has served as a member on the USFDA Veterinary Medicine Advisory Committee for the Center for Veterinary Medicine, the EPA’s FIFRA Science Advisory Panel, and National Academy of Sciences Committee. She currently serves on the Board of Directors of the C.L. Davis Foundation for the Advancement of Veterinary and Comparative Pathology. She was awarded the Society of Toxicologic Pathology’s Achievement Award in 2007 and the Midwest Regional Chapter – Society of Toxicology’s Kenneth DuBois Award in 2011.

Affiliations and Expertise

Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Colin Rousseaux

Professor Rousseaux is a Fellow of the Royal College of Pathology, Diplomate of the American Board of Toxicology, Fellow of the Academy of Toxicological Sciences, and Fellow of the International Academy of Toxicologic Pathology. He is Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceutical, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former president of the Society of Toxicologic Pathology

Affiliations and Expertise

Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa Principal, Colin Rousseaux and Associates, Canada

Matthew Wallig

Professor Wallig is a Diplomate of the American College of Veterinary Pathologists. He is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables and soy, and the pathophysiology of pancreatic injury.

Affiliations and Expertise

Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Brad Bolon

During a 25-year career, Dr. Bolon has been employed in academia, contract research organizations, and two pharmaceutical firms before launching an experimental and toxicologic pathology practice.  His main professional interests include comparative pathology of genetically engineered animals and toxicologic neuropathology.  He is a past president of the Society of Toxicologic Pathology and is a recipient of the 2018 British Society of Toxicological Pathology’s Gopinath Lecture Award for excellence in toxicologic pathology.

Affiliations and Expertise

President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA

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