Handbook on the Toxicology of Metals: Volume I: General Considerations

Handbook on the Toxicology of Metals: Volume I: General Considerations

5th Edition - November 30, 2021

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  • Editors: Gunnar Nordberg, Max Costa
  • eBook ISBN: 9780128232934
  • Hardcover ISBN: 9780128232927

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Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health.

Key Features

  • Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems
  • Includes information on sources, transport and the transformation of metals in the environment
  • Covers the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health
  • Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment and prevention of metallic elements and compounds


Toxicologists, physicians, pharmacologists, and engineers in the fields of environmental and occupational health; governmental regulatory agencies, research labs, pharmaceutical and biotech companies, public health professionals

Table of Contents

  • 1. Toxicology of metals: Overview, definitions, concepts, and trends
    Gunnar F. Nordberg, Monica Nordberg and Max Costa
    2. General chemistry of metals, sampling, analytical methods, and speciation
    Donald R. Smith, Michael J. Maroney, Monica Nordberg and Julian F. Tyson
    3. Exposure, dose, and toxicokinetics of metals
    Alison Elder, Gunnar F. Nordberg, and Michael Kleinman
    4. Toxicity of metal and metal oxide nanoparticles
    Hanna L. Karlsson, Muhammet S. Toprak and Bengt Fadeel
    5. Toxicity of metals released from implanted medical devices
    Ronald P. Brown, Bruce A. Fowler, Silvia Fustinoni, Max Costa and Monica Nordberg
    6. Metals and air pollution
    Lung-Chi Chen, Polina Maciejczyk and George Thurston
    7. Toxic metals in food
    Agneta Oskarsson and Jan Alexander
    8. Interaction of toxic metals with the gut microbiome
    Wenbo Yan and Deepak Saxena
    9. Biological monitoring of metals and biomarkers
    Tiina Santonen, Greet Schoeters and Monica Nordberg
    10. Computational modeling and dosimetry of metals
    M. Moiz Mumtaz, Bruce A. Fowler and Patricia Ruiz
    11. Selected molecular mechanisms of metal toxicity and carcinogenicity
    Alex Heng Li and Max Costa
    12. Effects of metals on extracellular vesicle signaling
    Shan Liu, Max Costa and Angelica Ortiz
    13. General considerations of dose-effect and dose-response relationships
    Daphne B. Moffett, Moiz M. Mumtaz, DexterW. Sullivan Jr and Margaret H. Whittaker
    14. Interactions and mixtures in metal toxicology
    Gunnar F. Nordberg, Lars Gerhardsson, Moiz M. Mumtaz, Patricia Ruiz and Bruce A. Fowler
    15. Gene-Environment interactions and metal toxicity
    Karin Broberg and Natalia Pawlas
    16. Epidemiological approaches to metal toxicology
    Philippe Grandjean and Esben Budtz-Jørgensen
    17. Essential metals: assessing risks from deficiency and toxicity
    Peter Aggett, Gunnar F. Nordberg and Monica Nordberg
    18. The interaction of metals and the skin: the good, bad, and the ugly
    Mary S. Matsui, Tiffany Carle and Max Costa
    19. Metals and the respiratory tract
    Benoit Nemery
    20. Neurotoxicology of metals
    Airton C. Martins, Samuel W. Caito, David C. Bellinger, Roberto G. Lucchini and Michael Aschner
    21. Metals and cardiovascular disease
    Bengt Sjögren, Carolina Bigert and Per Gustavsson
    22. Renal effects of exposure to metals
    Carl-Gustaf Elinder and Lars Barregard
    23. Carcinogenicity of metal compounds
    Shan Liu and Max Costa
    24. Immunotoxicology of metals
    Per A. Hultman and K. Michael Pollard
    25. Effects of metallic elements on reproduction and development
    Giuseppe De Palma, Angelica Ortiz and Pietro Apostoli
    26. Ecotoxicology of metals-sources, transport, and effects on the ecosystem
    Poul Bjerregaard, Christian B.I. Andersen and Ole Andersen
    27. Risk assessment for metal exposures
    Gunnar F. Nordberg, Max Costa and Bruce A. Fowler
    28. Diagnosis and treatment of metal poisoning general aspects
    Lars Gerhardsson
    29. Principles for prevention of the toxic effects of metals
    Philip J. Landrigan, Roberto G. Lucchini, David Kotelchuck and Philippe Grandjean
    30. Metal toxicology in low-income and lower-middle-income countries
    Stephan Bose O’Reilly and Philip J. Landrigan

Product details

  • No. of pages: 796
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: November 30, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128232934
  • Hardcover ISBN: 9780128232927

About the Editors

Gunnar Nordberg

Gunnar Nordberg
Dr Gunnar F. Nordberg, MD, PhD, is an emeritus Professor at Umea University, Umea, Sweden, where he served as chairman of the Department of Environmental and Occupational Medicine for many years. He has also worked as a Professor and chair at the Department of Environmental Medicine, Odense University, Denmark and for periods of a year at the International Agency for Research on Cancer, Lyon, France and the University of North Carolina and the National Institute of Environmental Health Sciences, NC, USA. In his capacity as university professor, he tutored many PhD and master students in Environmental medicine, a number of them from countries around the world. He has published more than 300 papers in Scientific Journals and International Handbooks. In addition, he authored, edited or co-edited 24 Scientific Books and participated in International Task Groups evaluating Risks of Environmental Agents, which resulted in 30 international books or reports. Some of these publications resulted from his activities as a chairman of the Scientific Committee on the Toxicology of Metals, International Commission on Occupational Health. He is presently the Task Group Chairman of Cadmium Risk Assessment in the Toxicology and Risk Assessment Group of the International Union of Pure and Applied Chemistry. His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals and the application of such data for Human Risk Assessment. He has coordinated EU- projects on Environmental Epidemiology and Toxicology of Metals and participated as an active scientist in several such projects. He has been the principal investigator of many research projects funded by Swedish funding Agencies and is presently actively involved in such research. He is one of the editors of a Textbook in Swedish “Arbets- och Miljömedicin”, latest 4th edition 2019. Chief Editor, Handbook on the Toxicology of Metals, 5th Ed, published 2021 by Academic Press/Elsevier. He has extensive experience as an expert serving Swedish and International Authorities, such as the Swedish National Board of Health (Socialstyrelsen), Japan Food Safety Agency, US Environmental Protection Agency, National Institute of Environmental Health Sciences (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety/WHO Commission on Health and the Environment, Energy Panel; International Agency for Research on Cancer IARC, Lyon, France, Europe/European Environment Agency, Copenhagen; European Medicines Agency, London; European Food Safety Authority (EFSA), Parma, Italy.

Affiliations and Expertise

Emeritus Professor, Umea University, Department of Public Health and Clinical Medicine, Sweden

Max Costa

Professor Max Costa's research interests include molecular mechanisms of metal carcinogenesis, cancer, pharmacology, epigenetics, and chromatin structure. Dr. Costa has published over 380 papers and has authored a book on Metal Carcinogenesis Testing. He serves on the Editorial Board as an Associate Editor for the Elsevier Journal, Toxicology and Applied Pharmacology.

Affiliations and Expertise

Chair and Professor, Department of Environmental Medicine, and Professor, Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, NY, USA

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