Handbook on Opium

Handbook on Opium

History and Basis of Opioids in Therapeutics

1st Edition - January 29, 2022

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  • Author: Vasanth Kumar
  • eBook ISBN: 9780323909044
  • Paperback ISBN: 9780323909037

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Description

Handbook of Opium: History and Basis of Opioids in Therapeutics traces the history of poppy from its prehistory, its use in Greek and Egyptian medicine through the European Renaissance, and the opioid epidemic of the present day. The book explores the discovery of morphine and its alkaloids, reviews its biosynthetic process, and covers the evolution of synthetic opioids. Further, it reviews the biological effects of opium and the molecular basis of its actions, including future perspectives in clinical applications with therapeutic targets. The book is interspersed with numerous notes on the events and great minds in history and medicine who advocated, analyzed and advanced opium through history. The book is a comprehensive review on opium, covering a breadth of topics, including its history, botany, chemistry, trade, physiology, clinical use and molecular biology, with numerous references, tables, vignettes and illustrations included for additional understanding.

Key Features

  • Presents a comprehensive review on opium, covering a range of topics
  • Filled with historical vignettes, tables and illustrations to aid understanding
  • Authored by practicing clinicians who integrate clinical information in the context of history and pharmacology

Readership

Anesthesiologists, pain management physicians, neurologists, internists and researchers. Biologists, pharmacists, residents and health care students, medical historians, paramedical professionals. Researchers in substance abuse. sociologists and anthropologists. Policy makers and law enforcement

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Cover Image Insert
  • Dedication
  • About the Author
  • Preface
  • Acknowledgments
  • Part I: Plant
  • Chapter 1: Botanical aspects
  • Abstract
  • 1.1: Plant
  • 1.2: Latex
  • 1.3: Opium alkaloids
  • 1.4: Synopsis
  • References
  • Part II: History
  • Chapter 2: Prehistory
  • Abstract
  • 2.1: Paleobotanical evidence
  • 2.2: Archaeological evidence
  • 2.3: Genetic evidence
  • 2.4: Evolutionary milestones
  • 2.5: Synopsis
  • References
  • Chapter 3: Ancient history
  • Abstract
  • 3.1: Opium in antiquity
  • 3.2: Ancient Egypt
  • 3.3: Classical history
  • 3.4: Dawn of common era
  • 3.5: Synopsis
  • References
  • Chapter 4: Postclassical history
  • Abstract
  • 4.1: Late Antiquity
  • 4.2: Islamic Renaissance
  • 4.3: Eastern opium
  • 4.4: Synopsis
  • References
  • Chapter 5: Modern history
  • Abstract
  • 5.1: European Renaissance
  • 5.2: Early modern
  • 5.3: Opium intemperance
  • 5.4: Opium in the East
  • 5.5: Late modern
  • 5.6: First opioid epidemic
  • 5.7: Chronology of opium
  • 5.8: Synopsis
  • References
  • Chapter 6: Contemporary history
  • Abstract
  • 6.1: Wars and anesthesia
  • 6.2: Second opioid epidemic
  • 6.3: Synopsis
  • References
  • Part III: Trade
  • Chapter 7: Business of opium
  • Abstract
  • 7.1: Before Common Era
  • 7.2: Religion, free trade, and colonialism
  • 7.3: Commercialization
  • 7.4: Licit trade
  • 7.5: Illicit trade
  • 7.6: Legislation
  • 7.7: Synopsis
  • References
  • Part IV: Alkaloids
  • Chapter 8: Opiates
  • Abstract
  • 8.1: Discovery
  • 8.2: Synthesis
  • 8.3: Opium alkaloids
  • 8.4: Synopsis
  • References
  • Chapter 9: Opioids
  • Abstract
  • 9.1: The family
  • 9.2: Structure-activity relationships
  • 9.3: Common opioids
  • 9.4: Unique formulations
  • 9.5: Milestones in opioid synthesis
  • 9.6: Synopsis
  • References
  • Part V: Molecular basics
  • Chapter 10: Receptors
  • Abstract
  • 10.1: Overview
  • 10.2: Endogenous opioid peptides
  • 10.3: Opioid receptor terminology
  • 10.4: Ligand characteristics
  • 10.5: Receptor structure
  • 10.6: Kinetics of conformational changes
  • 10.7: Distribution of opioid receptors
  • 10.8: Milestones
  • 10.9: Synopsis
  • References
  • Chapter 11: Effectors
  • Abstract
  • 11.1: Overview
  • 11.2: Heterotrimeric G proteins
  • 11.3: G protein/GPCR complex
  • 11.4: G protein-dependent pathways
  • 11.5: G protein-independent pathways
  • 11.6: Molecular mechanisms of opioid effects
  • 11.7: Synopsis
  • References
  • Part VI: Benefits and harms
  • Chapter 12: Metabolism
  • Abstract
  • 12.1: Overview
  • 12.2: Opioid metabolism
  • 12.3: Synopsis
  • References
  • Chapter 13: Analgesia
  • Abstract
  • 13.1: Overview of pain
  • 13.2: Nociceptors
  • 13.3: Transmission pathways
  • 13.4: Perception and modulation
  • 13.5: Opioid analgesia
  • 13.6: Synopsis
  • References
  • Chapter 14: Adverse effects
  • Abstract
  • 14.1: Overview
  • 14.2: Respiratory
  • 14.3: Gastrointestinal
  • 14.4: Integumentary
  • 14.5: Genitourinary
  • 14.6: Neurological
  • 14.7: Cardiovascular
  • 14.8: Endocrine and reproductive
  • 14.9: Mood disorders
  • 14.10: Neuroinflammation
  • 14.11: Angiogenesis and tumorigenesis
  • 14.12: Tolerance
  • 14.13: Withdrawal
  • 14.14: Opioid-induced hyperalgesia
  • 14.15: Dependence
  • 14.16: Other adverse effects
  • 14.17: Synopsis
  • References
  • Part VII: Therapeutic utility
  • Chapter 15: Uses and issues
  • Abstract
  • 15.1: Opioids in therapeutics
  • 15.2: Therapeutic principles
  • 15.3: Therapeutic predicament
  • 15.4: Acute pain
  • 15.5: Chronic pain
  • 15.6: Opioid use disorder
  • 15.7: Other issues
  • 15.8: Synopsis
  • References
  • Chapter 16: Advances and prospects
  • Abstract
  • 16.1: Opium production
  • 16.2: Overview of therapeutic advances
  • 16.3: Abuse-deterrent formulations
  • 16.4: Peripheral selectivity
  • 16.5: Molecular targets
  • 16.6: Gene therapy
  • 16.7: Synopsis
  • References
  • Index

Product details

  • No. of pages: 244
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 29, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323909044
  • Paperback ISBN: 9780323909037

About the Author

Vasanth Kumar

Dr. Vasantha K Kumar, MD is a currently a practicing anesthesiologist at Mercy Health, located in Cincinnati, OH. Board certified in Pain Medicine and Anesthesiology (American Board of Anesthesiology), he has been practicing for 20 years and has published over 70 peer reviewed journal papers and presentations. He is a member of the American Medical Association, the American Society of Anesthesiologists, Spine Intervention Society, and American Society of Regional Anesthesia.

Affiliations and Expertise

Anesthesiologist, Mercy Health, Cincinnati, OH, USA

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