Handbook on Miniaturization in Analytical Chemistry

Nano-based miniaturized devices can provide advantages to many areas of scientific research, yet the fundamentals and real-world applications of these devices remain largely unknown. The trend of device miniaturization requires significant changes to design, manufacturing, and production management, and it presents even greater challenges at the nanometer scale. Nanomachining technology involves not only physical-chemical processes (as in the case of microfabrication), but also application and integration of molecular biology principles. The Handbook on Miniaturization in Analytical Chemistry addresses the challenges of nano-based miniaturized devices and tools, their fabrication, and their applications at both experimental and theoretical model scales.

The Handbook on Miniaturization in Analytical Chemistry provides a source of authoritative fundamentals, interdisciplinary knowledge, and primary literature for researchers who want to fully understand how nano-technologies work and integrate them into their analysis. Covering all stages of analysis from sample preparation to separation and detection, the book discusses the design and manufacturing technology of miniaturization and includes an entire section on safety risks, ethical, legal, and social issues (ELSI), the economics of nanotechnologies, and a discussion on sustainability with respect to nano- and Lab-on-chip technologies. A guide for students and researchers working on applications of nanotechnology in modern systems for analysis, the Handbook on Miniaturization in Analytical Chemistry gives readers everything they need to know to bring their current practices up to date and to benefit from the time and money savings miniaturization can offer.

• Details the impacts of miniaturization and nanotechnology on all stages of analysis for the first time in a single volume , targeting the design, fabrication, modeling, and application of nano-miniaturized devices for analytical sciences
• Includes coverage of the current challenges for scaling up nano-miniaturization design and manufacturing technology for analysis
• Provides up-to-date further reference materials, including websites of interest and details on the latest research, in every chapter

Researchers studying and using nano-miniaturized systems for analysis in the fields of analytical chemistry, nanotechnology, chemical engineering, forensic sciences, pharmaceutical sciences, environmental analysis, toxicology, green chemistry, sustainability, materials science, device engineering, etc. who work at universities and industrial institutions, government and independent institutes, and individual research groups

1. Introduction: Era of nano for lab-on-chip

SECTION 1: Sample Preparation Stage of Analysis
2. Sample preparation techniques
3. Microfluidics for extraction techniques
4. Magnetic NMs in sample preparation

SECTION 2: Separation/Identification Stage of Analysis
5. Micro fabricated chromatographic techniques
6. Lab-on-chip for spectroscopic techniques
7. Nanotechnology in lab-on-chip membranes

SECTION 3: Detection Stage of Analysis
8. Lab-on-chip detector
9. Analytical sensors

SECTION 4: Other Applications
10. Point-of-care applications
11. Mobile-phone-based sensors

SECTION 5: Important Aspects and challenges
12. Safety risk of nano and socio-economic aspects
13. Laboratory synthesis to commercial applications
14. Green analysis with lab-on-chip devices
15. Conclusion: Future of analytical chemistry