Handbook of Toxicology of Chemical Warfare Agents

Handbook of Toxicology of Chemical Warfare Agents

3rd Edition - March 31, 2020

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  • Editor: Ramesh Gupta
  • Hardcover ISBN: 9780128190906
  • eBook ISBN: 9780128190913

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Description

Handbook of Toxicology of Chemical Warfare Agents, Third Edition, covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, and countermeasures. Expanding on the second edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a new chapter on emergency preparedness, coverage of the chemical warfare agents used in Syria, the use of the Novichok agent in the UK, and more.

Key Features

  • Unites world-leading experts to bring you cutting-edge, agent-specific information on Chemical Warfare Agents (CWA) and their adverse effects on human and animal health, and the environment
  • Provides you with all the information you need on CWA modes of action, detection, prevention, therapeutic treatment and countermeasures
  • New to this edition: a full update to reflect the most recent advances in the field and new chapters on emergency preparedness, the chemical warfare agents used in Syria, and the use of the Novichok agent in the UK

Readership

Toxicologists, defense scientists, homeland and governmental security, and risk assessment specialists

Table of Contents

  • Section I: Historical Perspective and Epidemiology
    1. History of Toxicology: From Killers to Healers
    2. Historical Perspective of Chemical Warfare Agents
    3. Global Impact of Chemical Warfare Agents Used Before and After 1945   
    4. Sarin Attacks in Japan: Acute and Delayed Health Effects in Survivors
    5. Early and Delayed Effects of Sulfur Mustard in Iranian Veterans After the Iraq–Iran Conflict
    6. Epidemiology of Chemical Warfare Agents
    7. Chemical Weapons of Mass Destruction and Terrorism: A Threat Analysis

    Section II: Agents That Can Be Used as Weapons of Mass Destruction
    8. Organophosphate Nerve Agents
    9. Russian VX
    10. Novichoks
    11. Blister Agents
    12. Riot Control Agents
    13. Phosgene oxime
    14. Psychotomimetic Agent BZ (3-Quinuclidinyl Benzilate)
    15. Fluoroacetate
    16. Strychnine
    17. Superwarfarins
    18. PCBs, Dioxins and Furans: Human Exposure and Health Effects  
    19. Polycyclic Aromatic Hydrocarbons: Implications for Developmental, Molecular, and Behavioral Neurotoxicity
    20. Thallium
    21. Arsenicals: Toxicity, Their Use as Chemical Warfare Agents, and Possible Remedial Measures
    22. Chlorine
    23. Phosgene
    24. Carbon Monoxide: Can’t See, Can’t Smell, Body Looks Red But They Are Dead
    25. Acute Cyanide Toxicity and its Treatment: The Body is Dead and Maybe Red but Does Not Stay Red for Long
    26. Methyl Isocyanate: The Bhopal Gas
    27. Other Toxic Chemicals as Potential Chemical Warfare Agents
    28. Ricin
    29. Botulinum Toxin
    30. Onchidal and Fasciculins
    31. Cyanobacterial (Blue-Green Algae) Toxins

    Section III: Target Organ Toxicity
    32. Chemical Warfare Agents and the Nervous System
    33. Behavioral Toxicity of Nerve Agents
    34. The Respiratory Toxicity of Chemical Warfare Agents
    35. Cardiovascular System as a Target of Chemical Warfare Agents
    36. Ocular Toxicity of Chemical Warfare Agents
    37. Skeletal Muscle
    38. Dermal Toxicity of Sulfur Mustard
    39. Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents
    40. Liver Toxicity of Chemical Warfare Agents
    41. Renal System
    42. Impact of Chemical Warfare Agents on the Immune System

    Section IV: Special Topics
    43. Health Effects of Nuclear Weapons and Releases of Radioactive Materials
    44. Clinical and Cellular Aspects of Traumatic Brain Injury
    45. Neurological Effects and Mechanisms of Blast Overpressure Injury
    46. Genomics and Proteomics in Brain Complexity in Relation to Chemically-Induced PTSD
    47. Excitotoxicity, Oxidative Stress, and Neuronal Injury
    48. Blood–Brain Barrier Damage and Dysfunction by Chemical Toxicity
    49. The Effects of Organophosphates in the Early Stages of Human Skeletal Muscle Regeneration
    50. Experimental modeling for delayed effects of organophosphates
    51. Alternative Animal Toxicity Testing of Chemical Warfare Agents

    Section V: Toxicokinetics, Toxicodynamics and Physiologically-Based Pharmacokinetics
    52. Toxicokinetic Aspects of Nerve Agents and Vesicants
    53. Toxicokinetics and Toxicodynamics of DFP
    54. Physiologically Based Pharmacokinetic Modeling of Chemical Warfare Agents
    55. Biotransformation of Warfare Nerve Agents

    Section VI: Analytical Methods, Biosensors and Biomarkers
    56. Laboratory Analysis of Chemical Warfare Agents, Adducts, and Metabolites in Biomedical Samples
    57. On-Site Detection of Chemical Warfare Agents
    58. Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed Neuropathic Agents
    59. The crosslinking action of organophosphorus poisons; implications for chronic neurotoxicity
    60. Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents

    Section VII: Risks to Animals and Wildlife
    61. Potential Agents That Can Cause Contamination of Animal Feedingstuff and Terror
    62. Chemical Warfare Agents and Risks to Animal Health
    63. Threats to Wildlife by Chemical and Warfare Agents

    Section VIII: Emergency Preparedness, Prophylactic, Therapeutic and Countermeasures
    64. Pharmacological Prophylaxis Against Nerve Agent Poisoning: Experimental Studies and Practical Implications 
    65. Prophylactic and Therapeutic Measures in Nerve Agents Poisoning
    66. Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling of Countermeasures to Nerve Agents
    67. Research on Medical Countermeasures for Chemical Attacks on Civilians
    68. Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds
    69. Novel Cholinesterase Reactivators
    70. Paraoxonase (PON1), detoxication of nerve agents, and modulation of their toxicity
    71. The role of carboxylesterases in therapeutic interventions of nerve agent poisoning
    72. Catalytic bioscavengers: the new generation of bioscavenger-based medical countermeasures

    Section IX: Decontamination and Detoxification
    73. Rapid Decontamination of Chemical Warfare Agents from the Skin

Product details

  • No. of pages: 1318
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: March 31, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128190906
  • eBook ISBN: 9780128190913

About the Editor

Ramesh Gupta

Ramesh Gupta
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in research on pesticide toxicity, neurodegenerative diseases, and nutraceuticals efficacy and safety. He has delivered lectures in UK, Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, Sweden, and Turkey. He served the panels of NIH, CDC, NIOSH, and NAS. He has >450 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Nutraceuticals: Efficacy, Safety and Toxicity. He is recipient of Murray State University's distinguished researcher award of the year-2006, and Outstanding research award of the year 2014. In 2019, he received a medal from The Royal Academy of Spanish Veterinary Sciences for his distinguished services to veterinary medicine. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences. Dr. Gupta is a member of many professional societies, including SOT, Eurotox, ASPET, American College of Toxicology, and ISSX.

Affiliations and Expertise

Professor, Toxicology Department, Murray State University, Murray, Kentucky, United States of America Head, Toxicology Department, Murray State University, Murray, Kentucky, United States of America

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