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Handbook of the Biology of Aging - 9th Edition - ISBN: 9780128159620, 9780128162835

Handbook of the Biology of Aging

9th Edition

Editors: Nicolas Musi Peter Hornsby
eBook ISBN: 9780128162835
Paperback ISBN: 9780128159620
Imprint: Academic Press
Published Date: 19th January 2021
Page Count: 468
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Table of Contents

1. Understanding Aging Through Conserved Longevity Pathways
2. Role of the somatotropic Axis in Mammalian Aging
3. Mitochondria in aging: Dysfunction
4. Aging of Stem Cells: Intrinsic Changes and Environmental Influences
5. Telomeres and Telomere Dysfunction in Aging
6. mTOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species
7. Sirtuins in Aging and Age-Related Diseases
8. Protein Homeostasis and Aging
9. Genetics of Human Aging
10. Calorie Restriction in Nonhuman and Human Primates
11. Terminal Weight Loss, Frailty, and Mortality
12. Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction
13. Aging and Adipose Tissue
14. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Intervention
15. Aging and Insulin Secretion
16. Cardiovascular Effects of Aging in Primates-Gender Differences
17. Cerebral Vascular Dysfunction with Aging
18. Pulmonary Function in Aging Humans
19. Bone Aging
20. Age-Related Changes in Thermoreception and Thermoregulation
21. Sex Differences in Longevity and Aging
22. Inflammation in Aging Processes: An Integrative and Ecological Perspective
23. Systems Biology Approaches to Understanding Aging
24. Evolutionary Biology of Aging
25. Epigenetic Control of Longevity
26. An Objective Appraisal of the Free Radical Theory of Aging
27. Aging Research: Promise and Pitfalls


Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.

Key Features

  • Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline
  • Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering
  • Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control
  • Examines the diverse research being conducted in the study of the biology of aging


Clinicians, researchers, and students in gerontology, developmental psychology, psychiatry, biology, and other related health care professions tasked with caring for the aging population


No. of pages:
© Academic Press 2021
19th January 2021
Academic Press
eBook ISBN:
Paperback ISBN:

Ratings and Reviews

About the Editors

Nicolas Musi

Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging.

Affiliations and Expertise

Sam and Ann Barshop Insititute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA

Peter Hornsby

Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.

Affiliations and Expertise

Sam and Ann Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA