Handbook of the Biology of Aging

Handbook of the Biology of Aging

9th Edition - January 19, 2021

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  • Editors: Nicolas Musi, Peter Hornsby
  • eBook ISBN: 9780128162835
  • Paperback ISBN: 9780128159620

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Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.

Key Features

  • Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline
  • Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering
  • Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control
  • Examines the diverse research being conducted in the study of the biology of aging


Clinicians, researchers, and students in gerontology, developmental psychology, psychiatry, biology, and other related health care professions tasked with caring for the aging population

Table of Contents

  • Part I: Basic mechanisms, underlying physiological changes, model organisms and interventions

    1. Longevity as a complex genetic trait

    2. DNA damage and repair in aging

    3. Mechanisms of cell senescence in aging

    4. The nature of aging and the geroscience hypothesis

    5. Sirtuins, healthspan, and longevity in mammals

    6. Integrative genomics of aging

    7. Thermogenesis and aging

    8. Yeast as a model organism for aging research

    9. Model organisms (invertebrates)

    10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging

    11. Aging in nonhuman primates

    Part II: Organ systems in humans and other animals, human health and longevity

    12. Senotherapeutics: Experimental therapy of cellular senescence

    13. The role of neurosensory systems in the modulation of aging

    14. Aging of the sensory systems: hearing and vision disorders

    15. Cardiac aging

    16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention

    17. Microbiome changes in aging

    18. Lipidomics of aging

    19. Trends in morbidity, healthy life expectancy, and the compression of morbidity

Product details

  • No. of pages: 468
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: January 19, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128162835
  • Paperback ISBN: 9780128159620

About the Editors

Nicolas Musi

Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging.

Affiliations and Expertise

Sam and Ann Barshop Insititute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA

Peter Hornsby

Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.

Affiliations and Expertise

Sam and Ann Barshop Institute for Longevity and Aging Studies, UT Health San Antonio, San Antonio, TX, USA

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