Handbook of Stress and the Brain (Two-Volume Set)

1st Edition


  • Thomas Steckler
  • N.H. Kalin
  • J.M.H.M. Reul
    • Not Applicable ISBN 9780444518224


    The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry. Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality. Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders.

    Key Features

    * Provides an overview of recent advances made in stress research * Includes timely discussion of stress and its effect on the immune system * Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms


    Researchers and clinicians in the fields of neuroscience, neurobiology, physiology, immunology, psychology, and psychiatry.


    No. of pages:
    © 2005
    Elsevier Science
    Not Applicable ISBN:

    About the authors

    Thomas Steckler

    Affiliations and Expertise

    Johnson & Johnson Pharmaceutical, Beerse, Belgium

    N.H. Kalin

    Affiliations and Expertise

    University of Wisconsin Medical School, Department of Psychiatry and Health Emotions Research Institute, Madison, WI, U.S.A.

    J.M.H.M. Reul

    Affiliations and Expertise

    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, U.K.


    "...everyone working on stress or stress-related subjects will want to have these volumes within reach of hand." --GENES, BRAIN AND BEHAVIOR (2006) 5: 304