Handbook of Sleep Research

Handbook of Sleep Research

1st Edition - June 21, 2019

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  • Editor: Hans Dringenberg
  • Hardcover ISBN: 9780128137437
  • eBook ISBN: 9780128137444

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Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders.

Key Features

  • Emphasizes a comparative and multidisciplinary approach to the topic of sleep
  • Covers the neurobiology and physiology of sleep stages, mechanisms of waking, and dreaming
  • Discusses in detail the proposed functions of sleep, from health and rest, to memory consolidation and synaptic plasticity
  • Examines the current state of research in mammalian and non-mammalian species, ranging from primates to invertebrates


Advanced students, basic researchers, and clinical researchers in behavioral neuroscience, cognitive neuroscience, developmental neuroscience, neurology, and sleep medicine

Table of Contents

  • Preface: Sleep research in the 21st century: advances and challenges
    Hans C. Dringenberg

    Theme A: Brain activity during sleep and waking
    1. Neuronal activity during the sleep-wake cycle
    Igor Timofeev, Sylvain Chauvette
    2. Timing and topography of sleep onset: asynchronies and regional changes of brain activity
    Maurizio Gorgoni, Aurora D’Atri, Serena Scarpelli, Michele Ferrara, Luigi De Gennaro
    3. Local patterns of sleep and wakefulness
    Giulio Bernardi, Francesca Siclari
    4. Hippocampal information processing and homeostatic regulation during REM and non-REM sleep
    Kenji Mizuseki, Hiroyuki Miyawaki

    Theme B: Regulation of Waking and Sleeping
    5. The circuit, cellular and synaptic bases of sleep-wake regulation
    Elda Arrigoni, Patrick M. Fuller
    6. Hypocretin and the regulation of sleep-wake transitions
    Natalie Nevárez, Luis de Lecea
    7. Serotonergic systems in sleep and waking
    Stephanie B. Linley, Robert P. Vertes
    8. Adenosinergic control of sleep/wake behavior
    Xuzhao Zhou, Michael Lazarus
    9. NREM sleep regulation from neuronal assembly to ion
    Heinrich S. Gompf, Christelle Anaclet
    10. Neurobiological mechanism of non-REM sleep
    Jonathan Chambers, Subimal Datta
    11. The genetic regulation of human sleep-wake rhythms and patterns
    Philip Kurien, Louis J. Ptáček, Ying-Hui Fu
    12. Circadian and homeostatic regulation of sleep
    Shoi Shi, Arthur Millius, Hiroki R. Ueda
    13. The role of glia in sleep-wake regulation and function
    Marcos G. Frank
    14. Interactions between sleep and breathing
    Leszek Kubin
    15. Neurobiological parallels, overlaps and divergences of sleep & anaesthesia
    Rachel Ward-Flanagan, Clayton T. Dickson

    Theme C: REM Sleep and Dreaming
    16. Neuroanatomical and neurochemical systems involved in REM sleep generation
    Luppi Pierre-Hervé
    17. Functions and circuits of REM sleep
    Mary Gazea, Carlos Del Rio-Bermudez, Christoph Nissen, Antoine R Adamantidis
    18. Structural and functional differences in brain mechanisms of dream recall
    Scarpelli S., Gorgoni M., D'Atri A., Ferrara M., De Gennaro L
    19. Consciousness and meta-consciousness during sleep
    Benjamin Baird, Daniel Erlacher, Michael Czisch, Victor I. Spoormaker, Martin Dresler

    Theme D: Evolution, Cross-Cultural and Comparative Approaches, and Novel Model Systems
    20. Evolution of sleep and adaptive sleeplessness
    John A. Lesku, Anne E. Aulsebrook, Michael L. Kelly, Ryan K. Tisdale
    21. Hunter-gatherer sleep and novel human sleep adaptations
    Gandhi Yetish, Ronald McGregor
    22. Sleep in Drosophila
    Leonie Kirszenblat, Bruno van Swinderen
    23. Sleep, immunity, and stress: novel insights from Drosophila
    Julie A. Williams
    24. Sleep in fish models
    Alex Keene, Lior Appelbaum
    25. Sleep in aquatic mammals
    Oleg Lyamin
    26. The role of sleep in song learning processes in songbird
    Nicolas Giret

    Theme E: Sleep, Plasticity, and Memory
    27. Sleep and brain development
    James P. Shaffery
    28. Sleep and plasticity
    Georgia Sousouri, Reto Huber
    29. Sleep-wake and cortical synaptic plasticity
    Igor Timofeev, Sylvain Chauvette
    30. Sleep stages and neural oscillations: A window into sleep’s role in memory consolidation and cognitive abilities
    N.H. van den Berg, A. Benoit, B. Toor, S. Fogel
    31. Cued memory reactivation: A tool to manipulate memory consolidation during sleep
    Jens G. Klinzing, Susanne Diekelmann
    32. Sleep and memory consolidation: conceptual and methodological challenges
    Hans C. Dringenberg

    Theme F: Sleep, Emotion, and Motivation
    33. The role of sleep in processing emotional information
    Kimberly A. Cote, Kari A. Lustig, Kevin J. MacDonald
    34. Sleep and emotions: on sleep, emotional memories and depression
    Leonore Bovy, Indira Tendolkar, Guillén Fernández, Martin Dresler
    35. Motivational processes in the regulation of sleep/wake states
    Ada Eban-Rothschild

    Theme G: Disturbed Sleep
    36. The effects of sleep loss on brain functioning
    Michele Bellesi
    37. Physiological and neurobehavioural consequences of chronic sleep restriction in rodent models
    Samuel Deurveilher, Kazue Semba
    38. Imaging of the sleep disordered brain
    Nathan Cross, Thien Thanh Dang-Vu
    39. Sleep impact on perception, memory, and emotion in adults and the effects of early life experience
    Monica Lewin, Regina M. Sullivan, Donald A. Wilson
    40. Sleep and driving
    Alistair W. MacLean
    41. Drug discovery and emerging treatments for sleep disorders
    Ana Clementina Equihua Benítez, René Drucker-Colín
    42. Insomnia pharmacotherapies: pharmacodynamics, strategies, new directions, and key measures in clinical trial investigations
    David N. Neubauer

    Theme H: Sleep in Aging and Disease
    43. Sleep and aging: circadian influences
    Suzanne Hood, Shimon Amir
    44. Sleep, physical activity, and cognitive health in older adults
    Teresa Liu- Ambrose, Ryan S. Falck
    45. Sleep in normal aging, Alzheimer’s disease and mild cognitive impairment
    Jean-François Gagnon, Alexandre Lafrenière, Géraldine Rauchs, Dominique Petit, Julie Carrier
    46. Sleep in major depression
    Umberto Moretto, Laura Palagini
    47. Closing the loop between circadian rhythms, sleep and attention deficit hyperactivity disorder
    Sudha Raman, Andrew N. Coogan
    48. Dissecting brain circuitry for sleep disorder narcolepsy in murine models
    Ying Sun, Emmaline Bendell, Carlos Blanco-Centurion, Priyattam J. Shiromani, Meng Liu
    49. Rapid Eye Movement Sleep Behavior Disorder: Pathological neural circuits and association with Parkinson's Disease
    Lora Kahn, Aviva Abosch, Drew S. Kern, Clete A. Kushida, MD, Casey H. Halpern, John A. Thompson

Product details

  • No. of pages: 756
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: June 21, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128137437
  • eBook ISBN: 9780128137444

About the Series Volume Editor

Hans Dringenberg

Dr. Dringenberg is professor in the Department of Psychology and the Centre for Neuroscience Studies at Queen’s University, Kingston, Ontario, Canada. He took up his position at Queen’s after completing a Ph.D. in Neuroscience at the University of Western Ontario, Canada, and a post-doctoral fellowship at the Institute of Physiological Psychology, University of Duesseldorf, Germany. Over the last 20 years, research in Dr. Dringenberg’s Neuroplasticity Laboratory has examined the role of various sleep-wake-related neuromodulators in controlling the electrical activity and synaptic plasticity of the neocortex and hippocampus in animal models. Recently, his lab has expanded its focus to also investigate the role of sleep and waking states in memory consolidation in humans. Dr. Dringenberg’s work has been funded by the Natural Sciences and Engineering Research Council of Canada (NSERC); he is the author of more than 80 peer-reviewed publications.

Affiliations and Expertise

Professor, Department of Psychology and Centre for Neuroscience Studies, Queen’s University, Kingston, Ontario, Canada

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