Handbook of Proteolytic Enzymes

Handbook of Proteolytic Enzymes


4th Edition - November 1, 2022

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  • Editors: Neil Rawlings, David Auld
  • Paperback ISBN: 9780128235874

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The Handbook of Proteolytic Enzymes: Metallopeptidases, Fourth Edition has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume, Metallopeptidases, includes over 300 chapters on known metallopeptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Key Features

  • Provides the only comprehensive book on metallopeptidases, including over 300 peptides
  • Written by experts from all groups of living organisms and viruses, including those that are currently major targets of pharmaceutical research
  • Includes a fully searchable text, 2D and 3D structures of peptidases in color, and links directly to PubMed and MEROPS databases
  • Details the latest proteotases used in therapeutic research and discusses recent drug trials


Active researchers in biochemistry, medical chemistry, organic chemistry, molecular biology, cell biology, pharmacology; clinician scientists; researchers in industry and pharma. Students of biochemical sciences; clinicians across disease specialties

Table of Contents

  • 1. Bacterial collagenase H
    2. Afg3-like protein 2
    3. YME1L1 protein
    4. Oma1 peptidase
    5. Csn5 peptidase
    6. Spartan peptidase
    7. RseP peptidase
    8. RPN11 peptidase
    9. Aminopeptidase N
    10. Cystinyl aminopeptidase
    11. Endoplasmic reticulum aminopeptidase 1
    12. Angiotensin-converting enzyme-2
    13. Thermolysin
    14. Pseudolysin
    15. Collagenase G/A (Clostridium histolyticum)
    16. Matrix metallopeptidase-1
    17. Matrix metallopeptidase-2
    18. Matrix metallopeptidase-3
    19. Matrix metallopeptidase-7
    20. Matrix metallopeptidase-9
    21. Matrix metallopeptidase-12
    22. Matrix metallopeptidase-13
    23. Membrane-type matrix metallopeptidase-1
    24. Meprin
    25. Procollagen C-peptidase
    26. ADAM10 peptidase
    27. ADAM17 peptidase
    28. ADAMTS13 peptidase
    29. Neprilysin
    30. Bontoxilysin
    31. Anthrax lethal factor
    32. i-AAA peptidase
    33. Dipeptidyl-peptidase III
    34. Carboxypeptidase B2
    35. Insulysin
    36. Nardilysin
    37. Xaa-Pro dipeptidase (eukaryote-type)
    38. Glutamate carboxypeptidase
    39. Glutamate carboxypeptidase II
    40. Lysostaphin

Product details

  • No. of pages: 808
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: November 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128235874

About the Editors

Neil Rawlings

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.

Affiliations and Expertise

Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK

David Auld

David S. Auld is Associate Professor of Pathology at Harvard in MA, USA.

Affiliations and Expertise

Associate Professor of Pathology, Harvard, MA, USA

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