Handbook of Proteolytic Enzymes

Handbook of Proteolytic Enzymes

3rd Edition - August 1, 2012

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  • Editors: Alan Barrett, Neil Rawlings, J. Woessner
  • eBook ISBN: 9780123822208

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Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.

Key Features

  • The only comprehensive book on proteolytic enzymes
  • Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research
  • Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases
  • Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features
  • Over 1000 peptidases included


Biochemists, Biotechnologists, Molecular and Cell Biologists, Biophysicists, Pharmaceutical Researchers, Biomedical Researchers, and Food Science Researchers

Table of Contents

  • Aspartic Peptidases: Introduction: aspartic peptidases and their clans; Rous sarcoma virus retropepsin and avian myeloblastosis virus retropepsin; Pepsin F
    Cysteine Peptidases: Introduction: the clans and families of cysteine peptidases; Coronavirus picornain-like cysteine proteinase; Calicivirus endopeptidases
    Metallopeptidases: Introduction: metallopeptidases and their clans; Ophiolysin; Philodryas venom metalloproteinases
    Serine Peptidases: Introduction: unsequenced serine peptidases; Muramoyl-pentapeptide carboxypeptidase; Tail-specific protease
    Threonine Peptidases: Introduction: clan PB containing N-terminal nucleophile peptidases; HslVU protease; Glycosylasparaginase and other self-processing N-terminal nucleophile amidohydrolases
    Unclassified Peptidases: Introduction: peptidases of unknown catalytic type; Murein tetrapeptide LD-carboxypeptidases; Tubulinyl-Tyr carboxypeptidase

Product details

  • No. of pages: 4094
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: August 1, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123822208

About the Editors

Alan Barrett

Affiliations and Expertise

Wellcome Trust Sanger Institute, Cambridge, U.K.

Neil Rawlings

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.

Affiliations and Expertise

Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK

J. Woessner

Affiliations and Expertise

University of Miami, Florida, U.S.A.

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