Handbook of Proteolytic Enzymes - 2nd Edition - ISBN: 9780120796113, 9780080984155

Handbook of Proteolytic Enzymes

2nd Edition

Editors: Alan Barrett J. Woessner Neil Rawlings
eBook ISBN: 9780080984155
Imprint: Academic Press
Published Date: 17th May 2004
Page Count: 984
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Description

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters.

This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme.

This book will prove useful to enzyme chemists and researchers.

Table of Contents


Editor Biographies

Contributors

Preface

Introduction

Abbreviations

Aspartic Peptidases

Introduction

1 Aspartic Peptidases and their Clans

2 Catalytic Pathway of Aspartic Peptidases

Clan AA

Family A1 3 Pepsin A

4 Pepsin B

5 Chymosin

6 Cathepsin E

7 Gastricsin

8 Cathepsin D

9 Napsin A

10 Renin

11 Mouse Submandibular Renin

12 Memapsin 1

13 Memapsin 2

14 Plasmepsins

15 Plasmepsin II

16 Tick Heme-Binding Aspartic Proteinase

17 Phytepsin

18 Nepenthesin

19 Saccharopepsin

20 Neurosporapepsin

21 Acrocylindropepsin

22 Aspergillopepsin I

23 Penicillopepsin

24 Endothiapepsin

25 Rhizopuspepsin

26 Mucorpepsin

27 Polyporopepsin

28 Candidapepsin

29 Candiparapsin

30 Canditropsin

31 Syncephapepsin

32 Barrierpepsin

33 Yapsin 1

34 Yapsin 2

35 Yapsin A

36 Pregnancy-Associated Glycoproteins

37 Pepsin F

38 Rhodotorulapepsin

39 Cladosporopepsin

40 Pycnoporopepsin

Family A2 and Others 41 Human Immunodeficiency Virus 1 Retropepsin

42 Human Immunodeficiency Virus 2 Retropepsin

43 Simian Immunodeficiency Virus Retropepsin

44 Equine Infectious Anemia Virus Retropepsin

45 Rous Sarcoma Virus Retropepsin and Avian Myeloblastosis Virus Retropepsin

46 Human T-Cell Leukemia Virus Type I (HTLV-I) Retropepsin

47 Bovine Leukemia Virus Retropepsin

48 Mason-Pfizer Monkey Virus Retropepsin

49 Mouse Mammary Tumor Virus Retropepsin

50 Moloney Murine Leukemia Virus Retropepsin

51 Feline Immunodeficiency Virus Retropepsin

52 Human Retrovirus K10 Retropepsin

53 Miscellaneous Viral Retropepsins

54 Spumapepsins

55 Fungal, Plant and Animal Retrotransposon Elements

56 Cauliflower Mosaic Virus Proteinase

Other Clans of Aspartic Peptidases

57 Nodavirus Endopeptidase

58 Signal Peptidase II

59 Type IV Prepilin Peptidase

60 Presenilins

61 Omptin

62 Plasminogen Activator of Yersinia Pestis

63 Scytalidopepsin B

64 Aspergillopepsin II

65 Scytalidopepsin A

66 Thermopsin

Metallopeptidases

Introduction

67 Metallopeptidases and their Clans

68 Catalytic Mechanisms for Metallopeptidases

Clan MA Subclan E

Family M1 69 Membrane Alanyl Aminopeptidase

70 Aminopeptidase Ey

71 Insect Aminopeptidase N

72 Aminopeptidase A

73 Pyroglutamyl-Peptidase II

74 Cystinyl Aminopeptidase, Oxytocinase and Insulin-Regulated Aminopeptidase

75 Aminopeptidase PILS

76 Aminopeptidase PS

77 Yeast Aminopeptidases Ape2, Aap1' and Yin7

78 Lysyl Aminopeptidase (Bacteria)

79 Aminopeptidase N (Streptomyces Lividans)

80 Leukotriene A4 hydrolase

81 Aminopeptidase B

Family M2 82 Peptidyl-Dipeptidase A/Angiotensin I-Converting Enzyme

83 Peptidyl-Dipeptidase A (Invertebrate)

84 Angiotensin-Converting Enzyme

Family M3 85 Thimet Oligopeptidase

86 Neurolysin

87 Saccharolysin

88 Oligopeptidase A

89 Peptidyl-Dipeptidase Dcp

90 Mitochondrial Intermediate Peptidase

91 Oligopeptidase F

92 Oligopeptidase PepB

93 Oligopeptidase MepB

Families M4, M5 and M9 94 Thermolysin and Related Bacillus Metallopeptidases

95 Lambda Toxin (Clostridium Perfringens)

96 Aureolysin

97 Listeria Metalloprotease Mp1

98 Griselysin

99 Coccolysin

100 Pro-Aminopeptidase Processing Protease

101 Vibriolysin

102 Pseudolysin

103 Legionella Metalloendopeptidase

104 Vimelysin

105 Mycolysin

106 Vibrio Collagenase

107 Clostridium Collagenases

Family M13 108 Neprilysin

109 Neprilysin-2

110 Endothelin-Converting Enzyme 1

111 Endothelin-Converting Enzyme 2

112 Endothelin-Converting Enzyme-Like Peptidase 1

113 PHEX Endopeptidase

114 Kell Blood-Group Protein

115 Neprilysin Homolog of Streptococci

116 Oligopeptidase O

Other Families in Subclan MA(E) 117 Tentoxylysin

118 Bontoxilysins

119 Hyicolysin

120 Procollagen III N-Proteinase

121 Ste24 Protease

122 Mammalian Famesylated Protein-Converting Enzyme 1

123 Baculovirus Enhancin

124 Glycyl Aminopeptidase (Sphingomonas)

Clan MA Subclan M

Families M10 and M11 125 Collagenase 1

126 Neutrophil Collagenase

127 Collagenase 3

128 Collagenase 4

129 Gelatinase A

130 Gelatinase B

131 Stromelysin 1

132 Stromelysin 2

133 Stromelysin 3

134 Matrilysin

135 Matrilysin 2

136 Macrophage Elastase

137 Membrane-Type Matrix Metalloproteinase 1

138 Membrane-Type Matrix Metalloproteinase 2

139 Membrane-Type Matrix Metalloproteinase 3

140 Membrane-Type Matrix Metalloproteinase 4

141 Membrane-Type Matrix Metalloproteinase 5

142 Membrane-Type Matrix Metalloproteinase 6

143 RASI-1, MMP-19

144 Enamelysin

145 Matrix Metalloproteinase 21

146 Chicken Matrix Metalloproteinase 22

147 Matrix Metalloproteinase 23

148 Epilysin

149 Plant Matrixins

150 Hydra Matrix Metalloproteinase (HMMP)

151 Envelysin

152 Serralysin and Related Enzymes

153 Aeruginolysin

154 Mirabilysin

155 Epralysin

156 Fragilysin

157 Gametolysin

Family M12 Subfamily A 158 Astacin

159 Meprin A

160 Meprin B

161 Procollagen C-Endopeptidase

162 Tolloid (Drosophila)

163 Mammalian Tolloid-Like Peptidases

164 Choriolysin L

165 Choriolysin H

166 Hydra Metalloproteinase 1 (HMP1)

167 Flavastacin

168 Other Astacin Homologs

Family M12 Subfamily B 169 Brevilysin H6

170 Acutolysin

171 Bilitoxin

172 Fibrolase

173 Venom Metalloproteinases of Agkistrodon Contortrix Laticinctus

174 Gloydius Halys Venom Metalloproteinases

175 Leucolysin

176 Bids Arietans Hemorrhagic Proteinases

177 Bothrops Asper Hemorrhagic Proteinases

178 Jararhagin

179 Bothrolysin

180 Bothropasin

181 Jararafibrases II-IV of Bothrops Jararaca

182 Basic Endopeptidases of Bothrops Moojeni Venom

183 Kistomin

184 Adamalysin

185 Atrolysin A

186 Atrolysin B

187 Atrolysin C

188 Atrolysin E

189 Atrolysin F

190 Atroxase

191 Basilysin

192 Horrilysin

193 Ruberlysin

194 Russellysin

195 Carinactivase

196 Multactivase

197 Ecarin

198 Mutalysins

199 Najalysin

200 Mocarhagin

201 Ophiolysin

202 Philodryas Venom Metalloproteinases

203 Trimerelysin I

204 Trimerelysin II

205 Mucrolysin

206 Lebetase

207 ADAM Metalloproteinases

208 ADAM9

209 ADAM28, Mouse Form

210 ADAM19

211 Kuzbanian (Drosophila)

212 ADAM12

213 Tumor Necrosis Factor α-Converting Enzyme

214 The ADAMTS Endopeptidases

215 ADAMTS1

216 Procollagen N-Endopeptidase, ADAMTS2

217 Aggrecanases 1 and 2

218 ADAMTS13: Von Willebrand Factor-Cleaving Protease

219 ADAM10, Myelin-Associated Metalloendopeptidase

Other Families in Clan MA 220 Pappalysin-1 (Pregnancy-Associated Plasma Protein-A)

221 Immune Inhibitor A

222 IgA Protease of Clostridium Ramosum

223 Snapalysin

224 Leishmanolysin

225 BlaR1 and MecR1 Gene Products of Staphylococcus Aureus

226 IgA-Specific Metalloendopeptidase

227 Carboxypeptidase Taq

228 Archaean Thermostable Carboxypeptidases

229 Anthrax Lethal Factor

230 Penicillolysin

231 Deuterolysin

232 Peptidyl-Lys Metalloendopeptidase

233 Fungalysin

234 FtsH Protease

235 Mitochondrial m- and i-AAA Proteases

236 Paraplegin

237 FtsH Homolog in Chloroplasts

238 Cytophagalysin

239 Dipeptidyl-Peptidase III

Clan MC

240 Carboxypeptidase A

241 Carboxypeptidase A2

242 Carboxypeptidase U

243 Mast Cell Carboxypeptidase

244 Carboxypeptidase B

245 Carboxypeptidase MeCPA

246 Carboxypeptidase T

247 Lysine Carboxypeptidase

248 Carboxypeptidase E

249 Carboxypeptidase Z

250 Adipocyte-Enhancer Binding Unit 1

251 Metallocarboxypeptidase D

252 Carboxypeptidase M

253 y-D-Glutamyl-(L)-Meso-Diaminopimelate Peptidase I

Clan MD

254 Zinc D-Ala-D-Ala Carboxypeptidase (Streptomyces)

255 D-Ala-D-Ala Carboxypeptidase VanY

256 VanX D-,D-Dipeptidase

257 N-Acetylmuramoyl-L-Alanine Amidase

Clan ME

258 Pitrilysin

259 Insulysin

260 Nardilysin

261 Axllp Gene Product (Saccharomyces Cerevisiae)

262 Mitochondrial Processing Peptidase

263 Chloroplast Stromal Processing Peptidase

264 Metalloprotease 1

265 Falcilysin

266 Vaccinia Virus Metalloproteinase

Clan MF

267 Leucyl Aminopeptidase (Animal)

268 Leucyl Aminopeptidase (Plant)

269 Leucyl Aminopeptidase PepA

270 Peptidase B (Escherichia Coli)

Clan MG

271 Methionyl Aminopeptidase Type 1

272 Methionyl Aminopeptidase Type 2

273 X-Pro Dipeptidase (Bacteria)

274 X-Pro Dipeptidase (Eukaryotes)

275 X-Pro Dipeptidase (Archaea)

276 X-Pro Aminopeptidase (Prokaryote)

277 X-Pro Aminopeptidase (Lactococcus)

278 Aminopeptidase P1

279 Aminopeptidase P2

Clan MH

280 Aspartyl Aminopeptidase

281 Aminopeptidase I

282 Glutamate Carboxypeptidase

283 Peptidase T

284 Peptidase V

285 Gly-X Carboxypeptidase

286 X-His Dipeptidase (Bacteria)

287 Sulfolobus Carboxypeptidase

288 Aminopeptidase Y

289 Streptomyces Griseus Aminopeptidase

290 Glutamate Carboxypeptidase II

291 Vibrio Aminopeptidase

292 Glutamyl Aminopeptidase (Lactococcus)

293 Bacillus Aminopeptidase I

294 N-Terminal Deblocking Aminopeptidase (Pyrococcus Furiosus)

Other Clans of Metallopeptidases

295 IadA β-Aspartyl Dipeptidase

296 O-Sialoglycoprotein Endopeptidase

297 Hydrogenase Maturation Endopeptidase

298 Endopeptidase GPR

299 S2P Protease

300 Sporulation Factor SpoIVFB

301 D-Aminopeptidase DppA

302 Membrane Dipeptidase

303 Dipeptidase AC (Acinetobacter)

304 β-Lytic Metalloendopeptidase

305 Staphylolysin

306 Lysostaphin

307 Aminopeptidase T

308 PepS Gene Product (Streptococcus Thermophilus)

Metallopeptidases not Yet Assigned to Families

309 Tripeptide Aminopeptidase

310 Clostridial Aminopeptidase

311 X-Trp Aminopeptidase

312 Tryptophanyl Aminopeptidase

313 Aminopeptidase yscCo-II

314 X-Arg Dipeptidase

315 Met-X Dipeptidase

316 Cytosol Nonspecific Dipeptidase

317 X-His Dipeptidase

318 β-Ala-His Dipeptidase

319 Lysosomal Dipeptidase

320 Peptidyl-Dipeptidase B

321 Peptidyl-Dipeptidase (Streptomyces)

322 Alanine Carboxypeptidase

323 Membrane Pro-X Carboxypeptidase

324 Carboxypeptidase G3

325 Mitochondrial Carboxypeptidase

326 Peptidyl-Asp Metalloendopeptidase

327 Magnolysin

328 Dactylysin

329 Myxococcus Xanthus Metalloendopeptidase

330 Dynorphin-Converting Enzyme

Appendix 1 Organisms Mentioned in the Handbook

Appendix 2 Suppliers Cited in the Handbook

Index

Details

No. of pages:
984
Language:
English
Copyright:
© Academic Press 2004
Published:
Imprint:
Academic Press
eBook ISBN:
9780080984155

About the Editor

Alan Barrett

Affiliations and Expertise

Wellcome Trust Sanger Institute, Cambridge, U.K.

J. Woessner

Affiliations and Expertise

University of Miami, Florida, U.S.A.

Neil Rawlings

Affiliations and Expertise

Wellcome Trust Sanger Institute, Cambridge, U.K.