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Handbook of Pediatric Brain Imaging - 1st Edition - ISBN: 9780128166338

Handbook of Pediatric Brain Imaging, Volume 2

1st Edition

Theory and Applications

Editors: Hao Huang Timothy Roberts
Paperback ISBN: 9780128166338
Imprint: Academic Press
Published Date: 1st October 2021
Page Count: 480
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Table of Contents

Section 1 Methods
1. Special considerations for acquisition of pediatric MRI of high spatial and temporal resolution
2. Frontiers of microstructural imaging with diffusion MRI
3. Advanced tractography and structural connectome
4. Functional connectome from rs-fMRI
5. Advanced pCASL pediatric perfusion MRI
6. Advanced fetal MRI
7. Special MRI (MWF, QMS, etc) sensitive to age
8. Multi-modal (diffusion, MRI rs-fMRI, MWF, QMS) sensitive to age
9. Pediatric MRS
10. Distortion and motion artifacts

Section 2 Post-processing
11. Accurate age-specific brain atlas and parcellations
12. Segmentation with varying contrasts of pediatric MRI
13. Shape analysis of maturing cerebral cortex
14. Network and graph analysis of developing brain
15. Prediction of neurodevelopmental outcomes based on basic and advanced MRI measurements

Section 3 Electrophysiology
16. MEG system for young children and recent progresses of infant MEG
17. MEG insights into brain development
18. MEG studies of children
19. The state-of-the-art pediatric EEG and MRI-compatible EEG

Section 4 Imaging Development and Disorders Thereof
20. Early brain structural a functional development (fetal, perinatal, infant)
21. Neuroimaging of early developing brain in health and disease
22. Neuroimaging of perinatal brain disorders
23. Current status of neuroimaging of pediatric neurological disorders (e.g. HIE, epilepsy, multiple sclerosis, brain tumor, stroke)
24. Conclusion: Leveraging multi-modal neuroimaging for pediatric neurological and psychiatric disorders


Handbook of Pediatric Brain Imaging: Theory and Applications presents state-of-the-art research on pediatric brain image acquisition and analysis from a broad range of imaging modalities, including MRI, EEG, MEG, PET, Ultrasound, NIRS and CT. With rapidly developing methods and applications of MRI, this book strongly emphasizes pediatric brain MRI, elaborating on the sub-categories of structure MRI, diffusion MRI, functional MRI, perfusion MRI and other MRI methods. It integrates a pediatric brain imaging perspective into imaging acquisition and analysis methods, covering head motion, small brain sizes, small cerebral blood flow of neonates, dynamic cortical gyrification, white matter tract growth, and much more.

Key Features

  • Presents state-of-the-art pediatric brain imaging methods and applications
  • Shows how to optimize the pediatric neuroimaging acquisition and analysis protocols
  • Illustrates how to obtain quantitative structural, functional and physiological measurements


Researchers and graduate students in biomedical engineering, engineering, computer science, physics and mathematics studying neuroimaging; technologically oriented scientists and clinicians


No. of pages:
© Academic Press 2021
1st October 2021
Academic Press
Paperback ISBN:

Ratings and Reviews

About the Editors

Hao Huang

Dr. Hao Huang is a Professor of Radiology in the Perelman School of Medicine at the University of Pennsylvania and Faculty Director of Small Animal Imaging Facility at Children’s Hospital of Philadelphia. He obtained his PhD in Biomedical Engineering from Johns Hopkins University School of Medicine in 2005. By pushing technical boundaries in advanced neural MRI acquisition and analysis, his works provide new knowledge on understanding circuits and functions of brain in health and disease. He has published more than 100 peer-reviewed articles in neuroimaging and neurobiological sciences with cutting-edge techniques in diffusion, perfusion and functional MRI as well as artificial intelligence algorithms. He is on the Editorial Board of NeuroImage. He serves as an Associate Editor for Frontiers in Neuroanatomy. He has served in a number of leadership positions in international committees. He maintains a strong NIH funding track-record and has been continuously funded by NIH R01 as a single principle investigator for more than 10 years. He has been recognized as the Distinguished Investigator of the Academy for Radiology and Biomedical Imaging Research in 2019. He has been elected as the Fellow of American Institute of Medical and Biological Engineering (AIMBE) in 2021.

Affiliations and Expertise

Faculty Director, Small Animal Imaging Facility, Children’s Hospital of Philadelphia; Associate Professor of Radiology, Perelman School of Medicine, University of Pennsylvania, USA

Timothy Roberts

Dr. Timothy Roberts is holder of the Oberkircher Family Chair in Pediatric Radiology and Vice-chair of Research in the Dept. of Radiology at the Children’s Hospital of Philadelphia and a tenured Professor of Radiology in the Perelman School of Medicine at the University of Pennsylvania. He received his PhD in MRI from Cambridge University in 1992. He has spent his career developing multimodal imaging and electrophysiological techniques for application to neurologic and psychiatric disorders. He has published over 300 peer-reviewed manuscripts in the field of functional and physiological imaging and has served as a grant reviewer for national funding agencies in more than a dozen countries. He serves as an Associate Editor for Frontiers in Integrative Neuroscience and has been recognized as a Distinguished Investigator of the Academy of Radiology Research (2016) and elected, in the inaugural class, as a Fellow of the American Society of Functional Neuroradiology (ASFNR) in 2019. He is a past president of the International Society for Clinical Magnetoencephalography (ISACM) as well as the ASFNR and has served on various committees of the International Society for Magnetic Resonance in Medicine and the American Society of Neuroradiology (ASNR).

Affiliations and Expertise

Oberkircher Family Chair of Pediatric Radiology and Vice-Chair of Research, Department of Radiology, Children’s Hospital of Philadelphia, USA