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Handbook of Neuroendocrinology - 1st Edition - ISBN: 9780123750976, 9780123785541

Handbook of Neuroendocrinology

1st Edition

Editors: George Fink Donald Pfaff Jon Levine
Hardcover ISBN: 9780123750976
eBook ISBN: 9780123785541
Imprint: Academic Press
Published Date: 31st August 2011
Page Count: 894
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Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggression, metabolism, birth, feeding and drinking and blood pressure are some of the bodily functions that are triggered and/or controlled by neuroendocrine systems. In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing’s Syndrome, hypertension or thyroid disorders. These as well as neuroendocrine tumors are some of the themes covered in the 36 chapters of the Handbook. Drafted by internationally acknowledged experts in the field, the Handbook chapters feature detailed up-to-date bibliographies as well as "how do we know?" call out sections that highlight the experimental or technical foundations for major concepts, principles, or methodological advances in each area. Aimed at senior undergraduate and graduate students, post-doctoral fellows and faculty in neuroscience, medicine, endocrinology, psychiatry, psychology and cognate disciplines, the Handbook of Neuroendocrinology satisfies an unmet need that will prove useful at the laboratory bench as well as in the office.

Key Features

  • The most comprehensive up-to-date source covering basic principles, neural regulation, hormone/brain function and behavior, and neuroendocrine pathology
  • "How do we know?" callout sections highlight core concepts
  • Heavily illustrated with over 350 figures, 4-color throughout


Researchers and clinicians in the fields of neuroendocrinology and behavior; graduate students in neuroscience and related disciplines (psychiatry, neuropharmacology, medicine & veterinary medicine); medical residents

Table of Contents

List of “How Do We Know?” Boxes


About the Editors

List of Contributors

Notes on Nomenclature

Chapter 1. An Introduction to Neuroendocrine Systems

Chapter 2. Neuroendocrine GPCR Signaling

Chapter 3. Neuroendocrine Feedback Control Systems

Chapter 4. Evolution of Reproductive Neurohormones

Chapter 5. Neural Control of the Anterior Lobe of the Pituitary Gland (Pars Distalis)

Chapter 6. Neural Control of the Posterior Pituitary Gland (Neurohypophysis)

Chapter 7. Neural Control of the Intermediate Lobe of the Pituitary Gland (Pars Intermedia) and Proopiomelanocortin

Chapter 8. The Hypothalamic–Pituitary–Adrenal Axis and Neuroendocrine Responses to Stress

Chapter 9. Neuroendocrine Control of Reproduction

Chapter 10. Lifetime Regulation of Growth Hormone (GH) Secretion

Chapter 11. Neuroendocrine Regulation of Development, Growth and Metabolism – Thyroid

Chapter 12. Circadian Rhythms in Neuroendocrine Systems

Chapter 13. Cardiovascular Neuroendocrinology

Chapter 14. Neuroendocrine Regulation of Food Intake

Chapter 15. Neuropeptide Regulation of Stress-Induced Behavior

Chapter 16. Neuroendocrine Regulation of Body Water and Electrolytes

Chapter 17. Sexual Differentiation of Brain and Behavior

Chapter 18. Corticosteroid Actions on Neurotransmission

Chapter 19. Neuroendocrine Mechanism of Puberty

Chapter 20. Sexual Behaviors

Chapter 21. Stress and Brain Function

Chapter 22. Neuroendocrinology of Aggression

Chapter 23. Chronic Social Stress

Chapter 24. Estrogen and Cognitive Aging in Women

Chapter 25. Hormones, Mood and Affect

Chapter 26. Hormones and the Aging Brain

Chapter 27. Kallmann Syndrome and Other Causes of Hypothalamic Hypogonadism and Related Development Disorders

Chapter 28. Parental Behavior and the Perinatal Programming of Infant Development

Chapter 29. Disorders of the Hypothalamic–Pituitary–Adrenocortical System

Chapter 30. Disorders of the Hypothalamic–Pituitary–Gonadal Axis

Chapter 31. Disorders of the Hypothalamic–Pituitary–Thyroid Axis

Chapter 32. Neuroendocrine Growth Disorders – Dwarfism, Gigantism

Chapter 33. Neuroendocrine Inherited or Induced Aromatase Enzyme Deficits

Chapter 34. Pituitary Adenomas

Chapter 35. Neuroendocrine Tumors

Chapter 36. Psychoneuroendocrinology

Subject Index

Author Index


No. of pages:
© Academic Press 2011
31st August 2011
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

George Fink

George Fink is a Neuroendocrinologist and Neuropharmacologist who has had a major interest in stress since the start of his career. He was recently appointed Vice President and Director of Research of the Pharmos Corporation in Israel and the United States, and is the former Director of the Medical Research Council's Brain Metabolism Unit and honorary professor in the University of Edinburgh in Scotland. Dr. Fink has published over 340 neuroendocrine papers and several authoritative books, and is past president of the European Neuroendocrine Association.

Affiliations and Expertise

Director, Mental Health Research Institute, Parkville, Victoria, Australia

Donald Pfaff

Donald W. Pfaff heads the Laboratory of Neurobiology and Behavior at The Rockefeller University. He received his scientific training at Harvard College and MIT. He is a Member of the U.S. National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences. Pfaff's laboratory focuses on steroid hormones and brain function, genes influencing neuronal functions, and generalized CNS arousal. He is the author or coauthor of over 10 books and more than 900 research publications.

Affiliations and Expertise

Laboratory of Neurobiology and Behavior, Rockefeller University, New York, USA

Jon Levine

Affiliations and Expertise

Professor, Department of Neurobiology and Physiology Northwestern University, Evanston IL, USA

Ratings and Reviews