Handbook of Mutagenicity Test Procedures

Handbook of Mutagenicity Test Procedures

2nd Edition - January 1, 1984

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  • Editors: B.J. Kilbey, M. Legator, W. Nicholson, C. Ramel
  • eBook ISBN: 9780444600981

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Description

The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

Table of Contents


  • Preface to the First Edition

    Preface to the Second Edition

    List of Contributors

    Chapter 1. Newer Methods for Determining Genotoxicity Using DNA Repair-Deficient and Repair-Proficient Escherichia coli

    Chapter 2. Bacillus Subtilis Repair Test

    Chapter 3. Methods for Studying Excision Repair of Eukaryotic DNA Damaged by Physical and Chemical Mutagens

    Chapter 4. Methods for Detecting Carcinogens and Mutagens with the Alkaline Elution/Rat Hepatocyte assay

    Chapter 5. Induced Reversion Using Human Adenovirus

    Chapter 6. Revised Methods for the Salmonella Mutagenicity Test

    Chapter 7. The Fluctuation Test in Bacteria

    Chapter 8. Mutagen Testing Using TRP+ Reversion in Escherichia coli

    Chapter 9. Methodologies for the Direct and Animal-Mediated Determination of Various Genetic Effects in Derivatives of Strain 343/113 of Escherichia coli

    Chapter 10. Basic Principles and Methods of Genotoxicity Testing in the Yeast Saccharomyces Cerevisiae

    Chapter 11. Procedures for the L5178y/TK+/- → TK-/- Mouse Lymphoma Cell Mutagenicity assay

    Chapter 12. a Quantitative Test for Mutagenicity in V79 Chinese Hamster Cells

    Chapter 13. Genetic Markers for Quantitative Mutagenesis Studies in Chinese Hamster Ovary Cells: Applications to Mutagen Screening Studies

    Chapter 14. Chemical Mutagenesis with Diploid Human Fibroblasts

    Chapter 15. 6-Thioguanine-Resistant Lymphocytes in Human Blood

    Chapter 16. The Specific Locus Test in the Mouse

    Chapter 17. Procedures and Evaluation of Results of the Mouse Spot Test

    Chapter 18. Human Peripheral Blood Lymphocytes for the Analysis of Chromosome Aberrations in Mutagen Tests

    Chapter 19. In Vitro Anaphase and Metaphase Preparations in Mutation Testing

    Chapter 20. The Bone Marrow Micronucleus Test

    Chapter 21. Cytogenetic Analysis of Structural Chromosome Aberrations and Aneuploidies in Oocytes, Zygotes and Preimplantation Embryos of Mammals

    Chapter 22. The Dominant Lethal assay in the Male Mouse

    Chapter 23. Test for Heritable Translocations in Male Mammals

    Chapter 24. The Methodology of Sister Chromatid Exchanges

    Chapter 25. Root Tips of Vicia Fab a for the Study of the Induction of Chromosomal Aberrations and Sister Chromatid Exchanges

    Chapter 26. Drosophila as An assay System for Detecting Genetic Changes

    Chapter 27. Eye Pigmentation Changes in Drosophila Melanogaster as a Sensitive Test for Mutagenicity

    Chapter 28. Metabolic Activation Systems in Short-Term In Vitro Tests

    Chapter 29. The Intraperitoneal Host-Mediated assay

    Chapter 30. The Isolated Perfused Liver as a Metabolizing System in Mutagenicity Testing

    Chapter 31. The Detection of Induced Chromosome Aneuploidy Using Strains of the Yeast Saccharomyces Cerevisiae

    Chapter 32. Methods for Detecting The Induction of Mitotic Chromosomal Misdistribution in aspergillus Nidulans

    Chapter 33. Systems for Detecting Meiotic Aneuploidy in Sordaria and Neurospora

    Chapter 34. Sperm Morphology Testing in Mice

    Chapter 35. Safety Precautions in Work with Mutagenic and Carcinogenic Chemicals

    Chapter 36. Handling of Mutagenic Chemicals: Experimental Safety

    Chapter 37. aspects of Statistical Inference in Testing for Genetic Toxicity

    Chapter 38. Prevention, Detection and Control of Mycoplasmal Infection of Cell Cultures

    Chapter 39. Mutation Epidemiology and Its Prospects for Detecting Human Germinal Mutagens

    Index


Product details

  • Language: English
  • Copyright: © Elsevier Science 1984
  • Published: January 1, 1984
  • Imprint: Elsevier Science
  • eBook ISBN: 9780444600981

About the Editors

B.J. Kilbey

M. Legator

W. Nicholson

C. Ramel

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