Handbook of Mucosal Immunology - 1st Edition - ISBN: 9780125247306, 9780323138529

Handbook of Mucosal Immunology

1st Edition

Serial Editors: Pearay Ogra Jiri Mestecky Michael E. Lamm Warren Strober Jerry McGhee John Bienenstock
eBook ISBN: 9780323138529
Imprint: Academic Press
Published Date: 11th January 1994
Page Count: 766
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Researchers have recently made tremendous progress in the area of mucosal immunology, greatly increasing our understanding of the common mucosal immune system, mucosal infections, and oral immunization. However, thisresearch has not previously been made available in a single work. In its large 81/2"x 11"format, Handbook of Mucosal Immunology covers the entire spectrum of mucosal immunity and is organized in two main sections to present the basic biology of the common mucosal immune system and the immune responses of the mucosae. The first section provides an introduction and historical perspective of the mucosal immune system and includes comprehensive discussion of the development and physiology of mucosal defense. It discusses such topics as the structure and function of themucosal epithelium, characteristics of mucosal-associated lymphoid tissue (MALT), Peyers patches, and concepts of mucosal vaccines. The second section focuses on the secretory immune system with special reference to mucosal diseases in the digestive (GALT), respiratory (BALT), and genitourinary tracts. This information is especially important in light of the current interest in the mechanisms, transmission, and prevention of infectious diseases such as AIDS, hepatitis, and tuberculosis. Virtually all chapters have been authored by the original investigators responsible for key observations on which current concepts are based. This handbook will be an invaluable resource for a diverse group of both researchers and practicing clinicians.Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology will all find this handbook the most complete work on the subject.


Molecular biologists, immunologists, veterinarians, public health workers, physicians in specialties from pediatrics to pulmonology, and graduate students of mucosal immunology.

Table of Contents

T.B. Tomasi,<$> Introduction: An Overview of the Mucosal System. Cellular Basis of Mucosal Immunity:<$> Development and Physiology of Mucosal Defense:<$> T. Kato and R.L. Owen,<$> Structure and Function of Intestinal Mucosal Epithelium. M.R. Neutra and J.-P. Kraehenbuhl,<$> Cellular and Molecular Basis for Antigen Transport in the Intestinal Epithelium. I.R. Sanderson and W.A. Walker,<$> Mucosal Barrier. K.M. Pruitt, F. Rahemtulla, and B. Mansson-Rahemtulla,<$> Innate Humoral Factors. C. Svanborg,<$> Bacterial Adherence and Mucosal Immunity. J. Mestecky and B. Underdown,<$> Mucosal Immunoglobulins. J.-P. Vaerman,<$> Developmental Aspects of Mucosal Immunoglobulins. K.L. Knight,<$> Developmental Aspects of Mucosal Immunoglobulin Genes: Organization and Expression of IgA Heavy Chain, Secretory Component and J-Chain Genes. P. Brandtzaeg, P. Krajci, M.E. Lamm, and C.S. Kaetzel,<$> Epithelial and Hepatobiliary Transport of Polymeric Immunoglobulins. M. Kilian and M.W. Russell,<$> Functions of Mucosal Immunoglobulins. Cells, Regulation, and Specificity in the Mucosal Immune System: Inductive Sites:<$> K. Croitoru and J. Bienenstock,<$> Characteristics and Functions of MALT. J. Cebraand K.E. Shroff,<$> Peyers Patches as Inductive Sites for IgA Commitment. W. Strober and R.O. Ehrhardt,<$> Regulation of IgA B Cell Development. L. Mayer,<$> Diversity and Functions of Antigen Presenting Cells in Mucosal Tissues. A. Mowat,<$> Oral Tolerance and Regulation of Immunity to Dietary Antigens. D.W. Pascual, A.M. Stanisz, and K.L. Bost,<$> Functional Aspects of the Peptidergic Circuit to Mucosal Immunity. F.G.M. Kroese, A.B. Kantor, and L.A. Herzenberg,<$> The Role of B-1 Cells (Ly-1 B Cells) in Mucosal Immune Responses. J.M. Phillips-Quagliata and M.E. Lamm,<$> Lymphocyte Homing to Mucosal Effector Sites. Cells, Regulation, and Specificity in the Mucosal Immune System: Effector Sites: Part A:<$> D.A. Lebman and R.L. Coffman,<$> Cytokines in the Mucosal Immune System. P. Brandtzaeg,<$> Distribution and Characteristics of Mucosal Immunoglobulin-Producing Cells. H. Kiyono and J.R. McGhee,<$> T Helper Cells for Mucosal Immune Responses. S.P. James and M. Zeitz,<$> Human Gastrointestinal Mucosal T Cells. L. Lefrancois,<$> Basic Aspects of Intraepithelial Lymphocytes. Part B:<$> K. Ishizaka,<$> IgE-Mediated Responses in the Mucosal Immune System. A.D. Befus,<$> Inflammation: Mast Cells. F. Anaya-Velazquez, G.D.F. Jackson, P.B. Ernst, B.J. Underdown, and J. Gauldie,<$> Cytokines in the Liver and Gastrointestinal Tract. S.D. London,<$> CTL in Mucosal Effector Sites. B.R. Murphy,<$> Mucosal Immunity to Viruses. Mucosal Immunization and Vaccines:<$> K.B. Renegar and P.A. Small, Jr.,<$> Passive Immunization: Systemic and Mucosal. J. Mestecky, R. Abraham, and P.L. Ogra,<$> Common Mucosal Immune System and Strategies for the Development of Vaccines Effective at the Mucosal Surfaces. S.M. Michalek, J.H. Eldridge, R. Curtiss III, and K.L. Rosenthal,<$> Antigen Delivery Systems: New Approaches to Mucosal Immunization. J.-P. Kraehenbuhl and M.R. Neutra,<$> Monoclonal Secretory IgA for Protection of the Intestinal Mucosa against Viral and Bacterial Pathogens. C.O. Elson and M.T. Dertzbaugh,<$> Mucosal Adjuvants. Mucosal Diseases: <$> Stomach, Intestine, and Liver:<$> T.T. MacDonald, and J. Spencer,<$> Gut Associated Lymphoid Tissue. J.-C. Rambaud, J.-C. Broulet, and M. Seligmann,<$> Alpha Chain Disease and Related Lymphoproliferative Disorders. B. Kaijser,<$> Gastritis and Peptic Ulcer. H.-C. Reinecker, S. Schreiber, W.F. Stenson, and R.P. MacDermott,<$> The Role of the Mucosal Immune System in Ulcerative Colitis and Crohns Disease. D. Nadal, C.P. Braegger, P. Knoflach, and B. Albini,<$> Malabsorption Syndromes and Intestinal Protein Loss. D.D. Metcalfe, Food Allergy. M.M. Levine and J.P. Nataro,<$> Intestinal Infections. W.R. Brown and C.D. Howell,<$> Liver andBiliary Tract. Lungs and Airways:<$> J. Bienenstock and R. Clancy,<$> Bronchial Mucosal Lymphoid Tissue. A.E. Redington, D.B. Jones, and S.T. Holgate,<$> Mucosal Immune Function in Asthma. R.C. Welliver,<$> Respiratory Infections. B. Bjorksten,<$> Inhalant Allergy and Hypersensitivity Disorders. Oral Cavity, Upper Airway, and Head and Neck:<$> D.A. Sullivan,<$> Ocular Mucosal Immunity. D. Lim and G. Mogi,<$> Mucosal Immunology of the Middle Ear and Eustachian Tube. D.J. Challacombe and P.J. Shirlaw,<$> Immunology of Diseases of the Oral Cavity. J.M. Bernstein, N. Yamanka, and D. Nadal,<$> The Immunobiology of the Tonsils and Adenoids. Mammary Glands:<$> R.M. Goldblum and A. Goldman,<$> Immunologic Components of Milk: Formation and Function. B. Carlsson and L.A. Hanson,<$> Immunologic Effecs of Breast Feeding on the Infant. Genitourinary Tract:<$> S.N. Emancipator and M.E. Lamm,<$> IgA Nephropathy and Related Diseases. M.B. Parr and E.L. Parr,<$> Mucosal Immunology in the Female and Male Reproductive Tracts. R.A. Bronson and F.M. Fusi,<$> Immunologically Mediated Male and Female Reproductive Failure. C.R. Wira, J. Richardson, and R. Prabhala,<$> Endocrine Regulation of Mucosal Immunity: Effect of Sex Hormones and Cytokines on the Afferent and Efferent Arms of the Immune System in the Female Reproductive Tract. P.D. Smith,<$> Mucosal Immunopathophysiology of HIV Infection. D.A. Tristram and P.L. Ogra,<$> Genital Tract Infection: Implications in the Prevention of Maternal and Fetal Disease. Chapter References. Subject Index.


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© Academic Press 1994
Academic Press
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About the Serial Editor

Pearay Ogra

Affiliations and Expertise

University of Texas Medical Branch, Galveston, U.S.A.

Jiri Mestecky

Affiliations and Expertise

University of Alabama, Birmingham, AL, U.S.A.

Michael E. Lamm

Affiliations and Expertise

Case Western Reserve University, Cleveland, Ohio, U.S.A.

Warren Strober

Affiliations and Expertise

NIH, Bethesda, MD, U.S.A.

Jerry McGhee

Affiliations and Expertise

University of Alabama, Birmingham, U.S.A. Adjunct Professor of Microbiology and Director of Immunology Vaccine Center

John Bienenstock

Affiliations and Expertise

McMaster University, Hamilton, Ontario, Canada


@qu:"The quality of the volume is exactly as would be expected from the track records of the editorial team. It is superb. There are more than 100 contributors, from 17 countries, 4 continents; they form the right mix of acknowledgedexperts, who have breadth and depth of experience and knowledge, and clearly explain their work at the leading edges of the field." "A readable book that is not just a mine of information, but offers workers in each subset of our complex discipline the opportunity to gain insight into and understanding of the issues being addressed by other groups. Such cross-fertilization will surely be an invaluable stimulus to new lines of interdisciplinary research." @source:--MUCOSAL IMMUNOLOGY UPDATE

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