Handbook of Models for Human Aging

Handbook of Models for Human Aging

1st Edition - February 24, 2006

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  • Editor: P. Michael Conn
  • eBook ISBN: 9780080460062

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The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.

Key Features

  • Utilizes a multidisciplinary approach
  • Shows tricks and approaches not available in primary publications
  • First volume of its kind to combine both methods of study for human aging and animal models
  • Over 200 illustrations


Researchers interested in the mechanisms of aging, gerontologists, health professionals, and allied health professionals and students

Table of Contents

  • I. Introduction

    1. Historical Development of Animal Models of Aging
    Richard L Sprott, Steven N Austad

    2. Species Selection in Comparative Studies of Aging and Anti-Aging
    Joao Pedro de Magalhaes

    3. Principles of Animal Use for Gerontological Research
    Richard A. Miller

    4. From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes
    Rita B Effros

    5. Models of Systems Failure in Aging
    Leonid A Gavrilov, Natalia S. Gavrilova

    6. Major Issues in Ethics of Aging Research
    Michael D Smith

    7. Ethical Aspects of Research Involving Elderly Persons
    Paul S Mueller, C. Christopher Hook

    II. General Methods

    8. SAGE KE and Other Online Resources Related to Aging
    Evelyn Strauss, R. John Davenport

    9. Proteomics in Aging Research
    Christian Schoneich

    10. Application of High-throughput Technologies to Aging-related Research
    Matt Kaeberlein

    11. Models of Alzheimer's Disease
    Harry LeVine, III, Lary C Walker

    12. Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs Normal Aging
    Scott A Small

    13. Epidemiology in Aging Research
    Hermann Brenner, Volker Arndt

    14. Statistical Issues for Longevity Studies in Animal Models
    Chenxi Wang, Scott Keith, Kevin R Fontaine, David B Allison

    15. Models for the Study of Infection in Populations
    John R Williams

    16. Estimation of the rate of production of oxygen radicals at mitochondria
    Alberto Sanz, Gustavo Barja

    III. Animal Models

    A. Premammalian Systems

    17. Telomeres and Aging in the Yeast Model System
    Kurt W Runge

    18. Longevity and Aging in the Budding Yeast
    Matt Kaeberlein

    19. From Yeast Methuselah Genes to Evolutionary Medicine
    Paolo Fabrizio, Valter D. Longo

    20. Strongyloides Ratti: A Nematode with Extraordinary Plasticity in Aging
    Michael P. Gardner, David Gems, Mark Viney

    21. Insect Models for the Study of Aging
    Klaus-Guenter Collatz

    22. Drosophila Models of Aging
    Satomi Miwa, Alan Cohen

    23. Models of Aging in Honeybee Workers
    Gro V Amdam, Olav Rueppel

    24. Ants as Naturally Long-lived Insect Models for Aging
    Joel D Parker, Karen M Parker

    B. Mammalian Systems

    25. Gene Expression and the Extended Longevity Phenotypes of Drosophila melanogaster
    Robert Arking

    26. Annual Fish as a Genetic Model for Aging
    Pudur Jagadeeswaran

    27. The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and Disease
    Evan T Keller, Jill M. Keller, Gavin Gillespie

    28. Zebrafish as Aging Models
    Shuji Kishi

    29. Telomeres In Aging: Birds
    Susan E. Swanberg, Mary E. Delany

    30. Domestic and Wild Bird Models for the Study of Aging
    Donna J. Holmes, M.A. Ottinger

    31. A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie Restriction
    Isao Shimokawa

    32. Rat Models of Age-related Cognitive Decline
    Jennifer L Bizon, Michelle M Nicolle

    33. Aged Rodents for Biogerontology Research
    Nancy L. Nadon

    34. Life Extension in the Dwarf Mouse
    Andrzej Bartke

    35. The Canine Model of Human Brain Aging: Cognition, Behavior, and Neuropathology
    P Dwight Tapp, Christina T Siwak

    36. Bats as a Novel Model for Aging Research
    Anja K Brunet-Rossinni, Rocco E. Rossinni

    37. Memory in the Aging Hippocampus: What can place cells tell us?
    Iain A Wilson

    38. The Rhesus Macaque as a Model of Human Aging and Age-Related Disease
    Mary Ann Ottinger, Jullie A. Mattison; Mary B. Zelinski, Julie M. Wu, Steve Kohama, George S. Roth, Mark A. Lane, Donald K. Ingram

    39. Non-human Primates as a Model for Reproductinve Aging and Human Infertility
    Barry D. Bavister, Carol A. Brenner

    IV. Comparative Models

    40. Neurobiology of the Aging Brain
    Carlo Bertoni-Freddari, Patrizia Fattoretti, William Meier-Ruge

    41. Mitochondrial DNA and Aging
    Mikhail Alexeyev, Susan P. LeDoux, Glen L. Wilson

    42. Models for Apoptosis
    Christiane Charriaut-Marlangue, Sylvain Renolleau

    43. Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive Senescence
    Jacqueline A. Maffucci, Andrea C. Gore

    44. Models of Chaperones in Aging
    Jens Kroll, J. O. Nehlin

    45. Therapeutic Potential of Stem Cells In Aging Related Diseases
    Shannon Whirledge, Kirk C.L. Lo, and Dolores J. Lamb

    46. Nuclear Transfer and Cloning: Preservaton or Expansion of Proliferative Lifespan?
    Keith E Latham

    47. Human Models of Longevity
    Thomas Perls

    48. Computational Models of Mitochondrial DNA in Aging
    David C Samuels

    49. Mouse Models of Accelerated Aging
    Jan Vijg, Paul Hasty

    V. Disease-States and Normal Aging

    A. Disease States

    50. Models, Definitions, and Criteria of Frailty
    David B. Hogan

    51. Fertility and Aging Men
    Peter N Schlegel, Puneet Masson, Sarah M. Lambert, Harry Fisch

    52. Benign Prostatic Hyperplasia
    Peter N Celec

    53. Murine Models of Infectious Diseases in the Aged
    Kevin P High

    54. Physiopathology, clinical symptoms and causative agents of pneumonia
    Jean-Paul Janssens

    55. Diabetes and Aging
    Tamas Fulop, A. Larbi; D. Tessier, A. Carpentier

    56. Diabetes as a Model of Premature Aging
    Arshag D Mooradian

    57. Frailty as a Model of Aging
    Jeremy D. Walston

    58. Osteoporosis and Cardiovascular Disease in the Elderly
    Samy I McFarlane, MD, FACP, FACE, CCD, John Nicasio, Ranganath Muniyappa

    59. Depression in Older Patients
    Kiran Rabheru

    60. The Aging Human Lung: Age-associated Changes in Structure and Function
    Keith C. Meyer

    61. Iceland as a Model for Human Aging
    Adalsteinn Gudmundsson, Palmi V Jonsson

    62. Behavior and Personality in the Study of Successful Aging
    Judith Corr, Lorraine Tarou

    B. Health Issues Affecting the Elderly

    63. Andropause
    Rabih Hijazi, Glenn R. Cunningham*

    64. Aging and the perceptual organization of sounds: a change of scene?
    Claude Alain, Benjamin J. Dyson, Joel S. Snyder

    65. Models of Immune Function in Aging
    Christopher A. Jolly, Zhun Xu

    66. Human T Cell Clones in Long-term Culture as Models for the Impact of Chronic Antigenic Stress in Aging
    Graham Pawelec, Erminia Mariani, Rafael Solana, Rosalyn Forsey, Anis Larbi, Simone Neri, Olga Dela Rosa, Yvonne Barnett, Jon Tolson, Tamas Fulop

    67. Age-Related Changes in the Human Retina
    Carlo Cavallotti, Nicola Pescosolido

    68. Models of Age Related Vision Problems
    J. Fielding Hejtmancik, Mark Kantorow, Takeshi Iwata

    69. Health, Functional and Therapeutic Implications of Obesity in Aging
    R L Kennedy, E Y H Khoo

    70. Age and Joints
    Klaus Bobacz, Ilse-Gerlinde Sunk

    71. Sleep Quality in the Elderly
    Ragnar Asplund

    72. Atherogenesis and Aging
    Cam Patterson

    73. Managing Menopausal Symptons
    Mary Ellen Rousseau

    74. Psychological Aging: A Contextual View
    Hans-Werner Wahl, Frieder R. Lang

    75. Nutrients and Aging
    Lawrence J Whalley

    C. Approaches to Treatment and Models

    76. Methods for Studying Hearing Impairment and Auditory Problems of the Aged
    Robert D Frisina, D. Robert Frisina

    77. A Model for Understanding the Pathomechanics of Osteoarthritis in Aging
    Thomas P Andriacchi, Annegret Mundermann

    78. Aging and Cardiovascular Angiogenesis Models
    Andrew Chin, Jacquelyn M. Holm, Inga J. Duignan, and Jay M. Edelberg*

    79. Models for the Study of Stroke
    Thiruma V. Arumugam, Mark P. Mattson*

    80. Werner Syndrome as a Model of Human Aging
    Raymond J Monnat, Jr

    81. Models of Sarcopenia
    Alfred L Fisher

    82. Aging of Human Skin
    Paolo U Giacomoni

    83. Models of Hypertension in Aging
    Jane F Reckelhoff, Radu Iliescu, Licy Yanes, Lourdes A Fortepiani

Product details

  • No. of pages: 1075
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: February 24, 2006
  • Imprint: Academic Press
  • eBook ISBN: 9780080460062

About the Editor

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and Expertise

Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USA

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  • Reham Mon Apr 23 2018


    Great detail and very well organized! What a great tool to have!