This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.

Key Features

*Utilizes a multidisciplinary approach *Shows tricks and approaches not available in primary publications *First volume of its kind to combine both methods of study for human aging and animal models *Over 200 illustrations


Researchers interested in the mechanisms of aging, gerontologists, health professionals, and allied health professionals and students

Table of Contents

I. Introduction 1. Historical Development of Animal Models of Aging Richard L Sprott, Steven N Austad 2. Species Selection in Comparative Studies of Aging and Anti-Aging Joao Pedro de Magalhaes 3. Principles of Animal Use for Gerontological Research Richard A. Miller 4. From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes Rita B Effros 5. Models of Systems Failure in Aging Leonid A Gavrilov, Natalia S. Gavrilova 6. Major Issues in Ethics of Aging Research Michael D Smith 7. Ethical Aspects of Research Involving Elderly Persons Paul S Mueller, C. Christopher Hook II. General Methods 8. SAGE KE and Other Online Resources Related to Aging Evelyn Strauss, R. John Davenport 9. Proteomics in Aging Research Christian Schoneich 10. Application of High-throughput Technologies to Aging-related Research Matt Kaeberlein 11. Models of Alzheimer's Disease Harry LeVine, III, Lary C Walker 12. Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs Normal Aging Scott A Small 13. Epidemiology in Aging Research Hermann Brenner, Volker Arndt 14. Statistical Issues for Longevity Studies in Animal Models Chenxi Wang, Scott Keith, Kevin R Fontaine, David B Allison 15. Models for the Study of Infection in Populations John R Williams 16. Estimation of the rate of production of oxygen radicals at mitochondria


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© 2006
Academic Press
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About the author

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve


"Taken all together, this handbook gives an excellent impression of what is done in aging research nowadays, which models are applied for which question and where the limitations of the models are. It covers very broadly standard models as well as more exotic, just emerging modles of aging research. Michael Conn has indeed achieved his goal of creating a comprehensive handbook covering all models of research." - Martina Rauner in WIENER MEDIZINISCHE WOCHENSCHRIFT