This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.

Key Features

*Utilizes a multidisciplinary approach *Shows tricks and approaches not available in primary publications *First volume of its kind to combine both methods of study for human aging and animal models *Over 200 illustrations


Researchers interested in the mechanisms of aging, gerontologists, health professionals, and allied health professionals and students

Table of Contents

I. Introduction 1. Historical Development of Animal Models of Aging Richard L Sprott, Steven N Austad 2. Species Selection in Comparative Studies of Aging and Anti-Aging Joao Pedro de Magalhaes 3. Principles of Animal Use for Gerontological Research Richard A. Miller 4. From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes Rita B Effros 5. Models of Systems Failure in Aging Leonid A Gavrilov, Natalia S. Gavrilova 6. Major Issues in Ethics of Aging Research Michael D Smith 7. Ethical Aspects of Research Involving Elderly Persons Paul S Mueller, C. Christopher Hook II. General Methods 8. SAGE KE and Other Online Resources Related to Aging Evelyn Strauss, R. John Davenport 9. Proteomics in Aging Research Christian Schoneich 10. Application of High-throughput Technologies to Aging-related Research Matt Kaeberlein 11. Models of Alzheimer's Disease Harry LeVine, III, Lary C Walker 12. Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs Normal Aging Scott A Small 13. Epidemiology in Aging Research Hermann Brenner, Volker Arndt 14. Statistical Issues for Longevity Studies in Animal Models Chenxi Wang, Scott Keith, Kevin R Fontaine, David B Allison 15. Models for the Study of Infection in Populations John R Williams 16. Estimation of the rate of production of oxygen radicals at mitochondria


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© 2006
Academic Press
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"Taken all together, this handbook gives an excellent impression of what is done in aging research nowadays, which models are applied for which question and where the limitations of the models are. It covers very broadly standard models as well as more exotic, just emerging modles of aging research. Michael Conn has indeed achieved his goal of creating a comprehensive handbook covering all models of research." - Martina Rauner in WIENER MEDIZINISCHE WOCHENSCHRIFT