Handbook of Membrane Channels - 1st Edition - ISBN: 9780125506403, 9780323138901

Handbook of Membrane Channels

1st Edition

Molecular and Cellular Physiology

Serial Editors: Camillo Peracchia
eBook ISBN: 9780323138901
Imprint: Academic Press
Published Date: 16th August 1994
Page Count: 591
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This handbook provides a thorough account of recent directions in membrane channel research. Each subject is covered in terms of channel biophysics, pharmacology, and molecular biology. The introductory chapter reviews methodologies of molecular biology currently used for studying molecular structure and function of membrane channels and specific domains in channel proteins.


This publication will interest primarily cellular and molecular biologists, biophysicists, physiologists, biologists, neuroscientists, pharmacologists, biochemists, and developmental biologists. There is a great possibility that this book will interest the research-oriented clinician due to the involvement of channel defects in the pathogenesis of numerous diseases.

Table of Contents

Section 1: Channels of Plasma Membranes: A. Potassium Channels. N. V. Shen and P.J. Pfaffinger,<$> Conservation of K+ Channel Properties in Gene Subfamilies. T. Begenisich,<$> The Permeation Properties of Cloned K+Channels. E. Stefani, L. Toro, E. Perozo, and F. Bezanilla,<$> Gating Currents of Cloned Shaker<$> K+ Channels. E. Vega-Saenz de Miera, M. Weiser, C. Kentros, D. Lau, H. Moreno, P. Serodio, and B. Rudy,<$> Shaw-Related K+ Channels in Mammals. R. Latorre,<$> The Molecular Workings of Large Conductance (Maxi) Ca2+-Activated K+ Channels. B. Sodium Channels.<$>P. Shrager and J.V. Wu,<$> Ionic Channels of Myelinated Axons. D. Krafte,<$> Cardiac Na Channel Expression in Xenopus<$> Oocytes. A.L. Goldin,<$> Molecular Analysis of Sodium Channel Inactivation. E. Moczydlowski and L. Schild,<$> Unitary Properties of Batrachotoxin-Trapped State of Voltage-Sensitive Sodium Channels. C. Calcium Channels.<$> Y. Mori,<$> Molecular Biology of Voltage-Dependent Calcium Channels. T. Tanabe,<$> Structure and Function of Skeletal Muscle and Cardiac Dihydropyridine Receptors.R.S. Kass,<$> Molecular Pharmacology of Cardiac L-Type Calcium Channels. B.P. Bean and I.M. Mintz,<$> Pharmacology of Different Types of Calcium Channels in Rat Neurons. D. Chloride Channels.<$> D.S. Weiss,<$> Voltage-Dependent Kinetics of the Fast Chloride Channel. R. Greger,<$> The Chloride Channels of Colonic Carcinoma Cells. A. Petris, C. Trequattrini, and F. Franciolini,<$> Structural Information on Background Chloride Channels as Obtained by Molecular Genetics. F. Franciolini and D.J. Adams,<$> Functional Properties of Background Chloride Channels. E. Ligand-Gated Channels.<$> J.G Montes, M. Alkondon, E.F.R. Pereira, and E.X. Albuquerque,<$> The Nicotinic Acetylcholine Receptor of the Mammalian Central Nervous System. M. Wilson,<$> Glutamate-Gated Channels in the Outer Retina. M.G. Darlison,<$> The Molecular Characterization of GABA-Gated Chloride-Ion Channels from Complex and Simple Nervous Systems. R.J. Vandenberg and P.R. Schofield,<$> The Inhibitory Ligand-Gated Ion Channel Receptors: Molecular Biology and Pharmacology of Gabaa and Glycine Receptors. F. Cyclic-NucleotideSensitive Channels.<$> D. DiFrancesco,<$> The Hyperpolarization-Activated (if) Current in Heart. V. Torre and A. Menini,<$> Selectivity and Single Channel Properties of the cGMP-Activated Channel in Amphibian Retinal Rods. G. Gap Junction Channels.<$> C. Peracchia, A. Lazrak, and L. Peracchia,<$> Molecular Models of Channel Interaction and Gating in Gap Junctions. E.C. Beyer and R.D. Veenstra,<$> Molecular Biology and Electrophysiology of Cardiac Gap Junctions. L. Ebihara,<$> Gap Junction Proteins in the Lens. H. Channels of the MPA-Box Family.<$> A.B. Chepelinsky,<$> The MIP Transmembrane Channel Family. I. Calmodulin-Sensitive Channels.<$> B. Martinac, X. Zhou, A. Kubalski, S. Sukharev, and C. Kung,<$> Microbial Channels.J. Microbial Channels.<$> Y. Saimi, K. Ling, and C. Kung,<$> Calmodulin-Sensitive Channels. Section II: Channels of Intracellular Membranes: A. Channels of Caldium Stores.<$> G. Meissner,<$> Ryanodine Receptor/Ca2+ Release Channel of ExcitableTissues. I. Zimanyi and I.N. Pessah,<$> Pharmacology of Ryanodine-Sensitive Ca2+ Release Channels. T.J. Shuttleworth,<$> The InsP3 Receptor and Intracellular Calcium Release. I. Bezprozvanny and B.E. Ehrlich,<$> The InsP3 Receptor: Functional Properties and Regulation. B. Mitochondria Channels.<$> H. Tedeschi and K.W. Kinnally,<$> Mitochondrial Membrane Channels. I. Inoue and T. Higuti,<$> ATP-Sensitive K+ Channels in the Inner Membrane of Rat Liver Mitochondria. C. Channels of Exocytotic Fusion.<$> J.R. Monck, A.F. Oberhauser, P.E.R. Tatham, and J.M. Fernandez,<$> Structure and Regulation of the Exocytotic Fusion Pore. Subject Index.


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© Academic Press 1994
Academic Press
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About the Serial Editor

Camillo Peracchia

Camillo Peracchia is a Professor Emeritus of Physiology and Pharmacology at the University of Rochester, School of Medicine. His research has focused on the structure and chemical regulation of cell-to-cell communication via gap junction channels and on the direct role of calmodulin in gap junction channel gating. Continuously funded by NIH for almost four decades, he has published over a hundred papers, authored a book and edited three others. He was an invited speaker at over forty international congresses and symposia, and has been Associate Editor of the Journal of Neurocytology. In 1994 he was elected Honorary Member of the “Societá di Medicina e Scienze Naturali” (University of Parma, Italy). He has served as Regular Member of the Cell Biology and Physiology Study Section (CBY-1, NIH, 1990-94), and is a National Reviewers Reserve (NIH, 1994-present). He is a member of the American Society for Cell Biology and the Biophysical Society. In March 2017 he received a Lifetime Achievement Award from Marquis Who’s Who. He has taught Respiratory Physiology to medical students and Cell Biology to graduate students. In recognition of his teaching activity, he was awarded the Manuel D. Goldman Prize (1998), the Edward F. Adolph Medal (2004), and five commendations (1995, 1996, 1999, 2002, 2005).

Affiliations and Expertise

Professor Emeritus, University of Rochester, School of Medicine New York, USA


@qu:The value of this book is that it illustrates the diversity of channel form and function in biological membranes; it utterly dispels the notion that ion channels are owned by the nervous system....The book gives equal weight to beasts from more exotic physiological climes--epithelial Cl- channels, gap junctions, aquaporins, cyclic nucleotide-activated channels, mitochondrial K+ channels, exocytotic fusion-pores, channels in bacteria, yeast, and protozoa, and the Ca2+-release channels of intracellular membranes. @source:--SCIENCE

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