Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes. The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design.

Key Features

Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the field Covers all aspects of industrial crystallization in a single, complete volume


Chemical engineers (industry and university) Biochemists, biotechnologists, and pharmaceutical scientists Materials scientists and engineers Process and plant engineers and designers

Table of Contents

Solutions and Solution Properties; Introduction and Motivation; Units; Solubility and Inorganics; Solubility of Organics; Supersaturation and Metastability; Solution Properties; Thermal Properties; Crystals, Crystal Growth, and Nucleation; Crystals; Nucleation; Crystal Growth; The Influence of Impurities and Solvents on Crystallization; Introduction; Factors Determining Crystal Shape; Influence of Solvents on Volume and Surface Diffusion Steps; Structure of the Crystalline Interface; Factors Affecting Impurity Incorporation; Effect of Impurities on Crystal Growth Rate; Some Chemical Aspects of Solvent and Impurity Interactions; Tailor-Made Additives; Effect of Solvents on Crystal Growth; Analysis and Measurement of Crystallization Utilizing the Population Balance; Particle Size and Distribution; Measurement of Size Distribution; The Mixed Suspension, Mixed Product Removal (MSMPR) Formalism for the Population Balance; Generalized Population Balance; Extension and Violations of the MSMPR Model; Crystallizer Selection and Design; Fundamentals; Selection of a Crystallizer; Equipment Types; Crystallizer Design Procedure; Instrumentation and Control; Crystallizer Costs; Precipitation Processes; Introduction; Physical and Thermodynamic Properties; Nucleation Kinetics; Crystal Growth Kinetics; Other Processes Attributes in Precipitation; Experimental Techniques; Modeling and Control of Crystal Size and CSD; Precipitation in Practice; Melt Crystallization; Definitions; Benefits of Melt Crystallization; Phase Diagrams; Crystallization Kinetics; Solid Layer Crystallization; Suspension Crystallization; Concepts of Existing Plants; The Sweating Step; The Washing Step; Continuous Plants; Crystallizer Mixing: Understanding and Modeling Crystallizer Mixing and Suspension Flow; Introduction; Crystallizer Flows; Distribution of Key Variables in Crystallizers; Crystallizers; Scale-up; Modeling; Control of Crystallization Processes; Introduction; Feedback Controllers; Industrial Crysta


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