Handbook of Hormones

Handbook of Hormones

Comparative Endocrinology for Basic and Clinical Research

2nd Edition - July 27, 2021

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  • Editors: Hironori Ando, Kazuyoshi Ukena, Shinji Nagata
  • eBook ISBN: 9780128206508
  • Paperback ISBN: 9780128206492

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Description

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival.

Key Features

  • Presents hormones in groups according to their origin so that readers can easily understand their inter-relation
  • Includes 47 new hormones, such as neuropeptides, cytokines, growth hormones, biogenic amines and amino acids that are important for cell to cell communication via endocrine, paracrine and neurotransmitter signaling
  • Summarizes the current knowledge of hormone evolution based on comparative genome resources, such as synteny, genome sequence and comprehensive phylogeny
  • Covers a wide range of information on hormones, from basic information on structure and function across vertebrate and invertebrate phyla to clinical applications
  • Collates key information on 259 hormones and 47 groups/families

Readership

Medical and biological researchers in endocrinology, comparative endocrinology, immunology, neurobiology, pharmacology, along with various clinical medicine such as pathology, cardiovascular biology, gastroenterology

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of editors
  • Contents of the companion site
  • Contributors
  • Preface to first edition
  • Preface to the second edition
  • Abbreviations
  • Volume 1
  • Part I: Peptides and proteins in vertebrates
  • Section I.1: Neuropeptides
  • Chapter 3: RFamide peptide family
  • Abstract
  • History
  • Structure
  • Molecular evolution of family members
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 3A: Gonadotropin-inhibitory hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 3B: Kisspeptin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 3C: PQRFamide peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 3D: Pyroglutamylated RFamide peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 3E: Prolactin-releasing peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 4: Corticotropin-releasing hormone family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 4A: Corticotropin-releasing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 4B: Urotensin I
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 4C: Urocortins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 4D: Sauvagine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 5: Gonadotropin-releasing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 6: Thyrotropin-releasing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 7: Somatostatin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 8: Neurohypophysial hormone family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 8A: Vasopressin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 8B: Vasotocin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 8C: Oxytocin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 8D: Nonmammalian OT-family peptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 9: Opioid peptide family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 9A: Enkephalin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 9B: Dynorphin/α-neo-endorphin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Subchapter 9C: Nociceptin/orphanin FQ
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 9D: Endomorphin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Subchapter 9E: Dermorphin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Chapter 10: Agouti family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 10A: Agouti-signaling protein
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 10B: Agouti-related protein
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 11: Tachykinin family
  • Abstract
  • History
  • Structure
  • Synthesis and release
  • Receptors
  • Signal transduction pathway
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 11A: Substance P/neurokinin A
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 11B: Neurokinin B
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 12: Appetite-regulating peptides
  • Abstract
  • History
  • Structures and receptors
  • Biological functions
  • Subchapter 12A: Melanin-concentrating hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 12B: Orexin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 12C: Cocaine- and amphetamine-regulated transcript
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 13: Urotensin II
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 14: Neurotensin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 15: Neuromedin U/S
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 16: Neuropeptide S
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 17: Neuropeptide W
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 18: Neuroendocrine regulatory peptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Chapter 19: Neurosecretory protein GL/neurosecretory protein GM
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 20: Nesfatin-1
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 21: Mexneurin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Chapter 22: Phoenixin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Section I.2: Adenohypophyseal hormones
  • Chapter 23: Glycoprotein hormone family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 23A: Follicle-stimulating hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 23B: Luteinizing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 23C: Thyroid-stimulating hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 24: Growth hormone/prolactin family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 24A: Growth hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 24B: Prolactin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Phenotype in gene-modified animals (PRL1)
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 24C: Somatolactin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 25: Proopiomelanocortin family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 25A: Adrenocorticotropic hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 25B: Melanocyte-stimulating hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 25C: Endorphin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Section I.3: Gastrointestinal hormones
  • Chapter 26: Glucagon family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 26A: Glucagon
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 26B: Gastric inhibitory peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 26C: Glucagon-like peptide-1
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 26D: Glucagon-like peptide-2
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 27: Secretin/pituitary adenylate cyclase-activating polypeptide family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 27A: Secretin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 27B: Growth hormone-releasing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 27C: Pituitary adenylate cyclase-activating polypeptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Subchapter 27D: Pituitary adenylate cyclase-activating polypeptide-related peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 27E: Vasoactive intestinal peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 27F: Peptide histidine isoleucine/methionine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Chapter 28: Insulin family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 28A: Insulin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 28B: Insulin-like growth factor-1
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathological implications
  • Supplemental information available on companion website
  • Subchapter 28C: Insulin-like growth factor-2
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathological implications
  • Supplemental information available on companion website
  • Subchapter 28D: Insulin-like growth factor binding proteins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathological implications
  • Supplemental information available on companion website
  • Subchapter 28E: Relaxins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 29: Gastrin family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 29A: Gastrin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 29B: Cholecystokinin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 29C: Caerulein
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 30: Ghrelin-motilin family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 30A: Ghrelin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 30B: Motilin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 31: Bombesin-like peptide family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 31A: Gastrin-releasing peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 31B: Neuromedin B
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 32: Guanylin family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 32A: Guanylin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Plasma concentration
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 32B: Uroguanylin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 33: Galanin peptide family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 33A: Galanin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 33B: Galanin-like peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 33C: Alarin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 34: Neuropeptide Y family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 34A: Pancreatic polypeptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 34B: Neuropeptide Y
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 34C: Peptide YY
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 35: Xenin
  • Abstract
  • Discovery
  • Structure
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Section I.4: Parathyroid gland, ultimobranchial gland and stannius corpuscle hormones
  • Chapter 36: Parathyroid hormone family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 36A: Parathyroid hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 36B: Parathyroid hormone-related protein
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 36C: Tuberoinfundibular peptide of 39 amino acids
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 37: Calcitonin/calcitonin gene-related peptide family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 37A: Calcitonin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 37B: Calcitonin gene-related peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 37C: Calcitonin receptor-stimulating peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 37D: Adrenomedullin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 37E: Adrenomedullin 2 and 5
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 37F: Amylin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 38: Stanniocalcin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Section I.5: Cytokines
  • Chapter 39: Immunological modulators
  • Abstract
  • History
  • Structures and biological functions
  • Subchapter 39A: Interleukins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 39B: Tumor necrosis factor
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 39C: Interferons
  • Abstract
  • Discovery
  • Structure and synthesis
  • Receptors and signaling pathways
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 40: Hematopoietic growth factors
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 40A: Erythropoietin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 40B: Thrombopoietin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 40C: Granulocyte colony-stimulating factor
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 41: Neurotrophin family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 41A: Nerve growth factor
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 41B: Brain-derived neurotrophic factor
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 41C: Neurotrophin-3
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Section I.6: Other peripheral hormones
  • Chapter 42: Renin-angiotensin system
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 42A: Renin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 42B: Angiotensin II
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 42C: Other angiotensins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 42D: Angiotensin converting enzyme
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 43: Kallikrein-kinin system
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 43A: Kininogen
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 43B: Kallikrein
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 43C: Bradykinin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 44: Apelin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 45: Elabela
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 46: Natriuretic peptide family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 46A: Atrial natriuretic peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 46B: B-type natriuretic peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 46C: C-type natriuretic peptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 46D: Ventricular natriuretic peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 47: Gonadal hormones
  • Abstract
  • History
  • Structures and biological functions
  • Subchapter 47A: Inhibin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 47B: Activin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 47C: Follistatin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 47D: Anti-Müllerian hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 48: Adipocyte hormones
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 48A: Leptin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 48B: Adiponectin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 48C: Acylation stimulating protein
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 48D: Resistin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 49: Endothelins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 50: Irisin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 51: Osteopontin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 52: Osteocrin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 53: Hepcidin antimicrobial peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 54: Adropin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Chapter 55: Lipocalin-2
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 2: Molecular evolution of peptide and protein hormones in vertebrates
  • Abstract
  • Introduction
  • Sequence homology and protein families
  • Orthology
  • Synteny
  • Omics solutions
  • Chapter 1: Evolution and diversity of animals
  • Abstract
  • Introduction
  • Metazoa
  • Protostomia
  • Deuterostomia
  • Evolution of hormones and their receptors
  • Volume 2
  • Part II: Peptides and proteins in invertebrates
  • Section II-1: Neuropeptides related to vertebrate hormones
  • Chapter 57: Gonadotropin-releasing hormone-like peptide family
  • Abstract
  • History
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 57A: Protochordate gonadotropin-releasing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 57B: Molluscan gonadotropin-releasing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 57C: Echinoderm gonadotropin-releasing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 58: Corticotropin-releasing factor-like peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 59: Oxytocin/vasopressin superfamily
  • Abstract
  • History
  • Structure
  • Receptor
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 59A: Lys-conopressin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 59B: Cephalotocin/octopressin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 59C: Annetocin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 59D: Inotocin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 59E: Nematocin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 59F: Ci vasopressin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 60: Neuropeptide F
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 61: Short neuropeptide F
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 62: RYamide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 63: Invertebrate tachykinin-like peptide family
  • Abstract
  • History
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 63A: Protochordata tachykinin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 63B: Invertebrate tachykinin-related peptide family
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 64: Insulin superfamily
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 64A: Insect insulin-like peptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 64B: Insect insulin-like growth factor-like peptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 64C: Molluscan insulin-related peptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 64D: Androgenic gland hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 64E: Relaxin-like gonad-stimulating peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 65: Sulfakinin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 66: Cionin: Ciona intestinalis cholecystokinin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 67: Ci-galanin-like peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 68: Allatostatin-C
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptor
  • Biological function
  • Chapter 69: Allatostatin-CC
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptor and biological functions
  • Chapter 70: Allatostatin-CCC
  • Abstract
  • Discovery
  • Structure
  • Receptor and biological functions
  • Chapter 71: Calcitonin-like diuretic peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 72: Ciona intestinalis calcitonin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 73: Amphioxus calcitonin family peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 74: Echinoderm calcitonin-type peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Section II-2: Invertebrate-unique peptides
  • Subsection II-2.1: Regulation of development and metabolism
  • Chapter 75: FXPRLamide peptide family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 75A: Diapause hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 75B: Pheromone biosynthesis activating neuropeptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subchapter 75C: Pyrokinin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Phenotype in gene-modified animals
  • Chapter 76: Crustacean hyperglycemic hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 77: Ion transport peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 78: Prothoracicotropic hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptor
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 79: Bursicon
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 80: Allatotropin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptor
  • Biological function
  • Chapter 81: Allatostatin-A
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptor
  • Biological function
  • Supplemental information available on companion website
  • Chapter 82: Adipokinetic hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 83: Adipokinetic hormone/corazonin-related peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 84: Neuroparsin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 85: Ovary maturating parsin
  • Abstract
  • Discovery
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subsection II-2.2: Regulation of myo/cardio-activities
  • Chapter 86: LF peptides
  • Abstract
  • History
  • Structure
  • Distribution of LF peptides
  • Biological functions
  • Subchapter 86A: Head activator
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Subchapter 86B: Hym-323
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 86C: Ciona LF peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 87: Invertebrate kinins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 88: FMRFamides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 89: Myoinhibiting peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptor
  • Biological function
  • Supplemental information available on companion website
  • Chapter 90: Myosuppressin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 91: Proctolin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 92: Orcokinins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 93: Crustacean cardioactive peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 94: Cardioacceleratory peptide 2b/CAPA
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 95: Achatina cardio-excitatory peptide-1
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Tissue content
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 96: Fulicins
  • Abstract
  • Discovery
  • Structure
  • Biological functions
  • Gene, mRNA, and precursor
  • Chapter 97: Buccalins
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 98: Eisenia inhibitory pentapeptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Chapter 99: GGNG peptides
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subsection II-2.3: Regulation of behaviors
  • Chapter 100: Eclosion hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Regulation of synthesis and release
  • Receptors
  • Biological functions
  • Chapter 101: Ecdysis triggering hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Regulation of synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 102: Sex peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Regulation of synthesis and release
  • Receptors
  • Biological functions
  • Chapter 103: APWGamide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 104: SIFamide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 105: Egg-laying hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Subsection II-2.4: Other hormones and neuropeptides
  • Chapter 106: Growth blocking peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 107: CCHamide
  • Abstract
  • Discovery
  • Structure
  • Structure and subtype
  • Synthesis and release
  • Distribution of mRNA
  • Receptors
  • Biological functions
  • Chapter 108: Corazonin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Regulation of synthesis and release
  • Receptors
  • Biological functions
  • Chapter 109: Pigment dispersing hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Regulation of synthesis and release
  • Receptors
  • Biological functions
  • Chapter 110: GLWamide
  • Abstract
  • Discovery
  • Structure
  • Biological functions
  • Chapter 111: Hym-176
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Chapter 112: Hym-301
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Chapter 113: Leech osmoregulatory factor
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 114: Ciona YFV/L peptide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 115: CNMamide
  • Abstract
  • Discovery
  • Structure
  • Structure and subtype
  • Synthesis and release
  • Biological functions
  • Chapter 116: Natalisin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 117: Elevenin
  • Abstract
  • Discovery
  • Structure
  • Structure and subtype
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 118: Glycoprotein hormone subunit A2/B5
  • Abstract
  • Discovery
  • Structure
  • Structure and subtype
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 119: Trissin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 120: EFLamide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 56: Molecular evolution of peptide and protein hormones in invertebrates
  • Abstract
  • Introduction
  • Diversity of invertebrate studies
  • Identification of neuropeptides and their receptors
  • Occurrence of neuropeptides and their receptors
  • Comparative gap between structure and functions
  • Overview of invertebrate endocrine control
  • Part III: Lipophilic hormones in vertebrates
  • Chapter 121: Thyroid hormones
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 121A: 3,3′,5-Triiodothyronine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 121B: Thyroxine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 121C: Thyronamines
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 122: Gonadal steroids
  • Abstract
  • History
  • Functions
  • Synthetic mechanisms
  • Quantification method
  • Receptors
  • Phenotype of receptor gene disrupted animals
  • Subchapter 122A: Progesterone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 122B: 17,20β-Dihydroxy-4-pregnen-3-one
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 122C: 17,20β,21-Trihydroxy-4-pregnen-3-one
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 122D: Dehydroepiandrosterone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Subchapter 122E: Testosterone/dihydrotestosterone
  • Abstract
  • Discovery
  • Structure of testosterone
  • Structure of DHT
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 122F: 11-Ketotestosterone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 122G: Estradiol-17β
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Plasma concentration (Table 122G.1)
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 122H: Estrone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Chapter 123: Corticosteroids
  • Abstract
  • History
  • Structure and biosynthesis
  • Corticosteroid receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 123A: Corticosterone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Pharmacological implications
  • Supplemental information available on companion website
  • Subchapter 123B: 18-Hydroxycorticosterone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 123C: 1α-Hydroxycorticosterone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 123D: Cortisol
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 123E: Aldosterone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 124: Neurosteroids
  • Abstract
  • History
  • Structure and biosynthesis
  • Regulation of biosynthesis
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 124A: Pregnenolone sulfate
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 124B: 7α-Hydroxypregnenolone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 124C: Allopregnanolone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 125: Vitamin D derivatives
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 125A: Calcitriol
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological function
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 125B: Cholecalciferol
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological function
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Part IV: Lipophilic hormones in invertebrates
  • Chapter 126: Ecdysteroid
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 126A: 20-Hydroxyecdysone
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 127: Juvenile hormone
  • Abstract
  • Discovery
  • Structure
  • Synthesis, release, and degradation
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Chapter 128: Methyl farnesoate
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Regulation of synthesis and release
  • Receptors
  • Biological functions
  • Supplemental information available on companion website
  • Part V: Endocrine disrupting chemicals
  • Chapter 129: Endocrine disruptors
  • Abstract
  • History
  • Biological functions
  • Receptors and structures
  • Subchapter 129A: Nonylphenol
  • Abstract
  • Discovery
  • Structure
  • Biological and pathophysiological implications
  • Subchapter 129B: Octylphenol
  • Abstract
  • Structure
  • Biological and pathophysiological implications
  • Subchapter 129C: Bisphenol A
  • Abstract
  • Discovery
  • Structure
  • Biological and pathophysiological implications
  • Subchapter 129D: Dichlorodiphenyltrichloroethane
  • Abstract
  • Discovery
  • Structure
  • Biological and pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 129E: 17α-Ethinylestradiol
  • Abstract
  • Discovery
  • Structure
  • Biological and pathophysiological implications
  • Subchapter 129F: Equilin
  • Abstract
  • Discovery
  • Structure
  • Biological and Pathophysiological Implications
  • Subchapter 129G: 2,3,7,8-Tetrachlorodibenzo-p-dioxin/polychlorinated biphenyls
  • Abstract
  • Discovery
  • Structure of TCDD
  • Structure of PCBs
  • Biological and pathophysiological implications
  • Subchapter 129H: 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors and biological functions
  • Subchapter 129I: Vinclozolin
  • Abstract
  • Discovery
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 129J: Polybrominated diphenyl ether
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Chapter 130: Antithyroid hormone active chemicals
  • Abstract
  • History
  • Structure
  • Biological functions and pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 130A: Tetrabromobisphenol A
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological and pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 130B: Perchlorate
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Biological and pathophysiological implications
  • Supplemental information available on companion website
  • Part VI: Amines and amino acids
  • Chapter 131: Amines
  • Abstract
  • History
  • Structure
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 131A: Dopamine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 131B: Noradrenaline/adrenaline
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 131C: Octopamine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 131D: Serotonin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 131E: Melatonin
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 131F: Histamine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 132: Amino acids
  • Abstract
  • History
  • Structure
  • Biological functions
  • Supplemental information available on companion website
  • Subchapter 132A: Glutamic acid
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 132B: γ-Aminobutyric acid
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 132C: Glycine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Chapter 133: Acetylcholine
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Part VII: Gasotransmitters
  • Chapter 134: Gasotransmitter family
  • Abstract
  • History
  • Structure
  • Receptors
  • Biological functions
  • Subchapter 134A: Nitric oxide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 134B: Carbon monoxide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Subchapter 134C: Hydrogen sulfide
  • Abstract
  • Discovery
  • Structure
  • Synthesis and release
  • Receptors
  • Biological functions
  • Pathophysiological implications
  • Supplemental information available on companion website
  • Index

Product details

  • No. of pages: 1174
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: July 27, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128206508
  • Paperback ISBN: 9780128206492

About the Editors

Hironori Ando

Sado Marine Biological Station, Faculty of Science, Niigata University, Niigata, Japan. His specific research interest involves neuroendocrine regulation of behavioral and physiological functions in diadromous migratory fish, such as salmonids and puffer fish.

Affiliations and Expertise

Marine Biological Station, Sado Island Center for Ecological Sustainability, Niigata University, Japan

Kazuyoshi Ukena

Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan. Professor Ukena discovered NPGL, a brain chemical that regulates hunger and fat storage in mammals, shows that hunger and energy consumption mechanisms are even more complex than we realized and has broad clinical and societal implications for the study and treatment of obesity and its associated diseases.

Affiliations and Expertise

Graduate School of Integrated Sciences for Life, Hiroshima University, Japan

Shinji Nagata

Graduate School of Frontier Science, The University of Tokyo, Chiba, Japan. His research interests incluces regulatory mechanisms of feeding behavior in insects at a molecular level. In the laboratory, they use insects to understand the underlying strategies used by animals to survive. A number of the techniques and devices required for such investigation are available for use, including the purification of biologically active compounds, protein and peptide purification, molecular cloning, intracellular signaling, and bioimaging.

Affiliations and Expertise

Graduate School of Frontier Science, The University of Tokyo, Japan

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