Handbook of Hormones

Handbook of Hormones

Comparative Endocrinology for Basic and Clinical Research

2nd Edition - July 27, 2021

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  • Editors: Hironori Ando, Kazuyoshi Ukena, Shinji Nagata
  • eBook ISBN: 9780128206508
  • Paperback ISBN: 9780128206492

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Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival.

Key Features

  • Presents hormones in groups according to their origin so that readers can easily understand their inter-relation
  • Includes 47 new hormones, such as neuropeptides, cytokines, growth hormones, biogenic amines and amino acids that are important for cell to cell communication via endocrine, paracrine and neurotransmitter signaling
  • Summarizes the current knowledge of hormone evolution based on comparative genome resources, such as synteny, genome sequence and comprehensive phylogeny
  • Covers a wide range of information on hormones, from basic information on structure and function across vertebrate and invertebrate phyla to clinical applications
  • Collates key information on 259 hormones and 47 groups/families


Medical and biological researchers in endocrinology, comparative endocrinology, immunology, neurobiology, pharmacology, along with various clinical medicine such as pathology, cardiovascular biology, gastroenterology

Table of Contents

    Molecule Evolution of Peptide and Protein Hormones in Vertebrates
    Section I.1. Neuropeptides
    Chapter 1. RFamide Peptide Family
    1A. Gonadotropin-Inhibitory Hormone
    1B. Kisspeptin
    1C. PQRFamide Peptide
    1D. Pyroglutamylated RFamide Peptide
    1E. Prolactin-Releasing Peptide
    Chapter 2. Corticotropin-Releasing Hormone Family
    2A. Corticotropin-Releasing Hormone
    2B. Urotensin-I
    2C. Urocortins
    2D. Sauvagine
    Chapter 3. Gonadotropin-Releasing Hormone
    Chapter 4. Thyrotropin-Releasing Hormone
    Chapter 5. Somatostatin/Neuronostatin
    Chapter 6. Neurohypophysial hormone family
    6A. Vasopressin
    6B. Vasotocin
    6C. Oxytocin
    6D. Non-Mammalian Oxytocin Family Peptides
    Chapter 7. Opioid Peptide Family
    7A. Enkephalin
    7B. Dynorphin/α-Neo-endorphin
    7C. Nociceptin/Orphanin FQ/Nocistatin
    7D. Endomorphin
    7E. Dermorphin
    Chapter 8. Agouti Family
    8A. Agouti-Signaling Protein
    8B. Agouti-Related Protein
    Chapter 9. Tachykinin Family
    9A. Substance P/Neurokinin A
    9B. Neurokinin B
    Chapter 10. Appetite-Regulating Peptides
    10A. Melanin-Concentrating Hormone
    10B. Orexin
    10C. Cocaine- and Amphetamine-Regulated Transcript
    Chapter 11. Urotensin II
    Chapter 12. Neurotensin
    Chapter 13. Neuromedin U/S /Precursor-related peptide
    Chapter 14. Neuropeptide S
    Chapter 15.  Neuropeptide W
    Chapter 16. Neuroendocrine Regulatory Peptide
    Chapter 17. Neurosecretory peptide GL/GM
    Chapter 18. Nesfatin-1
    Chapter 19. Mexneurin
    Chapter 20. Phoenixin

    Section I.2. Adenohypophysial Hormones
    Chapter 21. Glycoprotein Hormone Family
    21A. Follicle-Stimulating Hormone
    21B. Luteinizing Hormone
    21C. Thyroid-Stimulating Hormone
    Chapter 22. Growth Hormone/Prolactin Family
    22A. Growth Hormone
    22B. Prolactin
    22C. Somatolactin
    Chapter 23. Proopiomelanocortin Family
    23A. Adrenocorticotropic Hormone
    23B. Melanocyte-Stimulating Hormone
    23C. Endorphin
    Section I.3. Gastrointestinal Hormones
    Chapter 24. Glucagon Family
    24A. Glucagon
    24B. Gastric Inhibitory Peptide
    24C. Glucagon-Like Peptide-1
    24D. Glucagon-Like Peptide-2
    Chapter 25. Secretin (Pituitary Adenylate Cyclase-Activating Polypeptide) Family
    25A. Secretin
    25B. Growth Hormone-Releasing Hormone
    25C. Pituitary Adenylate Cyclase-Activating Polypeptide
    25D. Pituitary Adenylate Cyclase-Activating Polypeptide-Related Peptide
    25E. Vasoactive Intestinal Peptide
    25F. Peptide Histidine Isoleucine/Methionine
    Chapter 26. Insulin Family
    26A. Insulin
    26B. Insulin-Like Growth Factor-I
    26C. Insulin-Like Growth Factor-II
    26D. Insulin-Like Growth Factor Binding Proteins
    26E. Relaxins
    26F. Insulin like 6/relaxin-like factor/relaxin-insulin-like factor-1
    Chapter 27. Gastrin Family
    27A. Gastrin
    27B. Cholecystokinin
    27C. Caerulein
    Chapter 28. Ghrelin_Motilin Family
    28A. Ghrelin
    28B. Motilin
    28C. Liver-expressed antimicrobial peptide 2
    Chapter 29. Bombesin-Like Peptide Family
    29A. Gastrin-Releasing Peptide
    29B. Neuromedin B
    Chapter 30. Guanylin Family
    30A. Guanylin
    30B. Uroguanylin
    Chapter 31. Galanin Peptide Family
    31A. Galanin
    31B. Galanin-Like Peptide
    31C. Alarin
    Chapter 32. Neuropeptide Y Family
    32A. Pancreatic Polypeptide
    32B. Neuropeptide Y
    32C. Peptide YY
    Chapter 33. Chromogranin A/Pancreastatin
    Chapter 34. Xenin
    Section I.4. Parathyroid Gland, Ultimobranchial Gland, and Stannius Corpuscle Hormones
    Chapter 35. Parathyroid Hormone Family
    35A. Parathyroid Hormone
    35B. Parathyroid Hormone-Related Protein
    35C. Tuftelin-interacting protein 39
    Chapter 36. Calcitonin/Calcitonin Gene-Related Peptide Family
    36A. Calcitonin
    36B. Calcitonin Gene-Related Peptide
    36C. Calcitonin Receptor-Stimulating Peptide
    36D. Adrenomedullin
    36E. Adrenomedullin 2 and 5
    36F. Amylin
    Chapter 37. Stanniocalcin
    I-5. Cytokines and Growth Factors
    Chapter 38 Cytokines
    38A Interleukins
    38B Tumor necrosis factorα
    38C Interferones
    Chapter 39 Hematopoietic growth factors
    39A Erythropoietin
    39B Thrombopoietin
    39C Granulocyte colony-stimulating factor
    Chapter 40 Cell proliferation factors
    40A Epidermal growth factor
    40B Fibroblast growth factor
    40C Platelet-derived growth factor
    40D Hepatocyte growth factor
    40E Transforming growth factor
    Chapter 41 Neurotrophins
    41A Nerve growth factor
    41B Brain-derived neurotrophic factor
    41C Neurotrophin-3
    Section I.6. Other Peripheral Hormones
    Chapter 42. Renin-Angiotensin System
    42A. Renin
    42B. Angiotensin II
    42C. Other Angiotensins
    42D. Angiotensin Converting Enzymes
    42E. Vasoconstriction-inhibiting factor
    Chapter 43. Kallikrein-Kinin System
    43A. Kininogen
    343B. Kallikrein
    43C. Bradykinin
    Chapter 44. Apelin
    Chapter 45. ELABELA
    Chapter 46. Natriuretic Peptide Family
    46A. Atrial Natriuretic Peptide
    46B. B-type Natriuretic Peptide
    46C. C-type Natriuretic Peptides
    46D. Ventricular Natriuretic Peptide
    Chapter 47. Gonadal Hormones
    47A. Inhibin
    47B. Activin
    47C. Follistatin
    47D. Anti-Mullerian Hormone
    Chapter 48. Adipocyte Hormones
    48A. Leptin
    48B. Adiponectin
    48C. Acylation Stimulating Protein
    48D. Resistin
    Chapter 49. Endothelin
    Chapter 50. Irisin
    Chapter 51. Osteopontin
    Chapter 52. Osteocrin
    Chapter 53. Hepcidin/Liver-expressed antimicrobial peptide 1
    Chapter 54. Salusin
    Chapter 55. Adropin
    Chapter 56. Lipocalin-2

    Section II.1. Neuropeptides Related to Vertebrate Hormones
    Chapter 57. Gonadotropin-Releasing Hormone-Like Peptide Family
    57A. Protochordata Gonadotropin-Releasing Hormone
    57B. Molluscan Gonadotropin-Releasing Hormone
    57C. Echinoderm gonadotropin-releasing hormone
    Chapter 58. Corticotropin-Releasing Factor-Like Peptide
    Chapter 59. Oxytocin/Vasopressin Superfamily
    59A. Lys-Conopressin
    59B. Cephalotocin/Octopressin
    59C. Annetocin
    59D. Inotocin
    59E. Nematocin
    59F. Ci-Vasopressin
    Chapter 60. Neuropeptide F
    Chapter 61. Short Neuropeptide F
    Chapter 62. RYamide
    Chapter 63. Tachykinin-Like Peptide Family
    63A. Protochordate Tachykinin
    63B. Tachykinin-Related Peptides
    Chapter 64. Insulin Superfamily
    64A. Insect Insulin-Like Peptides
    64B. Insect Insulin-Like Growth Factor-Like Peptides
    64C. Molluscan Insulin-Related Peptides
    64D. Androgenic Gland Hormone
    64E. Relaxin-like Gonad-Stimulating Peptide
    Chapter 65. Sulfakinin
    Chapter 66. Cionin
    Chapter 67. Ci-Galanin-Like Peptide
    Chapter 68. Allatostatin-C
    Chapter 69. Calcitonin-like Diuretic Hormone
    Chapter 70. Ascidian calcitonin
    Chapter 71. Amphioxus calcitonin family peptide
    Chapter 72. Achinoderm calcitonin family peptide
    Section II.2. Invertebrate-Unique Peptides
    Subsection II.2.1 Regulation of Development and Metabolism
    Chapter 73. FXPRLamide Peptide Family
    73A. Diapause Hormone
    73B. Pheromone Biosynthesis Activating Neuropeptide
    73C. Pyrokinin
    Chapter 74. Crustacean Hyperglycemic Hormone
    Chapter 75. Ion Transport Peptide
    Chapter 76. Prothoracicotropic Hormone
    Chapter 77. Bursicon
    Chapter 78. Allatotropin
    Chapter 79. Allatostatin-A
    Chapter 80. Adipokinetic Hormone
    Chapter 81. Neuroparsin
    Chapter 82. Ovary Maturating Parsin
    Subsection II.2.2 Regulation of Myo/Cardio-Activities
    Chapter 83. LF Peptides
    83A. Head Activator
    83B. Hym-323
    Chapter 84. Invertebrate Kinins
    Chapter 85. FMRFamides
    Chapter 86. Myoinhibiting Peptide
    Chapter 87. Myosuppressin
    Chapter 88. Proctolin
    Chapter 89. Orcokinins
    Chapter 90. Crustacean Cardioactive Peptide
    Chapter 91. Cardioacceleratory Peptide 2b
    Chapter 92. Achatina Cardio-Excitatory Peptide-1
    Chapter 93. Fulicins
    Chapter 94. Buccalins
    Chapter 95. Eisenia Inhibitory Pentapeptides
    Chapter 96. GGNG Peptides

    Subsection II.2.3 Regulation of Behaviors
    Chapter 97. Eclosion Hormone
    Chapter 98. Ecdysis Triggering Hormone
    Chapter 99. Sex Peptide
    Chapter 100. APWGamide
    Chapter 101. SIFamide
    Chapter 102. Egg-Laying Hormone
    Subsection II.2.4 Other Hormones and Neuropeptides
    Chapter 103. Growth Blocking Peptide
    Chapter 104. Yamamarin
    Chapter 105. CCHamide
    Chapter 106. Corazonin
    Chapter 107. Trypsin-Modulating Oostatic Factor
    Chapter 108. Colloostatin
    Chapter 109. Pigment Dispersing Hormone
    Chapter 110. GLWamide
    Chapter 111. Hym-176
    Chapter 112. Hym-301
    Chapter 113. Leech Osmoregulatory Factor
    Chapter 114. Ciona YFV/L peptide

    Chapter 115. Thyroid Hormones
    115A. 3,30,5-Triiodothyronine
    115B. Thyroxine
    115C. Thyronamines
    Chapter 116. Gonadal Steroids
    116A. Progesterone
    116B. 17,20β-Dihydroxy-4-pregnen-3-one
    116C. 17,20β,21-Trihydroxy-4-pregnen-3-one
    116D. Dehydroepiandrosterone
    116E. Testosterone/Dihydrotestosterone
    116F. 11-Ketotestosterone
    116G. Estradiol-17β
    116H. Estrone
    Chapter 117. Corticosteroids
    117A. Corticosterone
    117B. 18-Hydroxycorticosterone
    117C. 1α-Hydroxycorticosterone
    117D. Cortisol
    117E. Aldosterone
    Chapter 118. Neurosteroids
    118A. Pregnenolone Sulfate
    118B. 7α-Hydroxypregnenolone
    118C. Allopregnanolone
    Chapter 119. Vitamin D Derivatives
    119A. Calcitriol
    119B. Cholecalciferol

    Chapter 120. Ecdysteroids
    120A. 20-Hydroxyecdysone
    Chapter 121. Juvenile Hormone
    Chapter 122. Methyl Farnesoate

    Chapter 123. Endocrine Disruptors
    123A. Nonylphenol
    123B. Octylphenol
    123C. Bisphenol A
    123D. Dichlorodiphenyltrichloroethane
    123E. 17α-Ethinylestradiol
    123F. Equilin
    123G. 2,3,7,8-Tetrachlorodibenzo-p-dioxin/Polychlorinated Biphenyls
    123H. 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene
    123I. Vinclozolin
    123J. Polybrominated Diphenyl Ether
    Chapter 124. Anti-Thyroid Hormone Active Chemicals
    124A. Tetrabromobisphenol A
    124B. Perchlorate
    PART VI Amines and Amino Acids
    Chapter 125 Amines
    125A Dopamine
    125B Noradrenaline
    125C Adrenaline
    125D Octopamine
    125E Serotonin
    125F Melatonin
    125G Histamine
    Chapter 126 Amino Acids
    126A Glutamic acid
    126B Gamma -Aminobutyric acid
    126C Glycine
    Chapter 127 Acetylcholine

    Chapter 128. Gasotransmitter Family
    128A. Nitric Oxide
    128B. Carbon Monoxide
    128C. Hydrogen Sulfide

Product details

  • No. of pages: 1174
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: July 27, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128206508
  • Paperback ISBN: 9780128206492

About the Editors

Hironori Ando

Sado Marine Biological Station, Faculty of Science, Niigata University, Niigata, Japan. His specific research interest involves neuroendocrine regulation of behavioral and physiological functions in diadromous migratory fish, such as salmonids and puffer fish.

Affiliations and Expertise

Marine Biological Station, Sado Island Center for Ecological Sustainability, Niigata University, Japan

Kazuyoshi Ukena

Graduate School of Integrated Arts and Sciences, Hiroshima University, Hiroshima, Japan. Professor Ukena discovered NPGL, a brain chemical that regulates hunger and fat storage in mammals, shows that hunger and energy consumption mechanisms are even more complex than we realized and has broad clinical and societal implications for the study and treatment of obesity and its associated diseases.

Affiliations and Expertise

Graduate School of Integrated Sciences for Life, Hiroshima University, Japan

Shinji Nagata

Graduate School of Frontier Science, The University of Tokyo, Chiba, Japan. His research interests incluces regulatory mechanisms of feeding behavior in insects at a molecular level. In the laboratory, they use insects to understand the underlying strategies used by animals to survive. A number of the techniques and devices required for such investigation are available for use, including the purification of biologically active compounds, protein and peptide purification, molecular cloning, intracellular signaling, and bioimaging.

Affiliations and Expertise

Graduate School of Frontier Science, The University of Tokyo, Japan

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