Description Table of Contents Details Editors Reviews

Description

This handbook provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans.

Key Features

* Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine * Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics * Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches

Readership

biology researchers working in genomics, proteomics, systems biology, bioinformatics and novel therapeutics; glycobiology investigators; students in related areas

Table of Contents

Introduction to Glycomics

SECTION 1: Glycoconjugate Structural Analysis 1. Glycoproteomics: N-glycan Analysis 2. Glycoproteomics: O-glycan Analysis 3. Glycosaminoglycans 4. Isotopic Labeling of Glycans for Quantitative Glycomics SECTION II: Glycotranscriptomics 5. Glycotranscriptomics SECTION III: Protein-Glycan Interactions 6. Glycan Arrays 7. Chromatographic and Mass Spectrometric Techniques

SECTION IV: Glycobioinformatics

8. Integration of Glycomics Knowledge and Data

9. KEGG GLYCAN for integrated analysis of pathways, genes, and glycan structures

10. European Glycomics Portal SECTION V: Glycomes

11. Glycomics of the Immune System

12. Mouse and Human

13. Drosophila

14. Malaria

15. Parasitic Worms

SECTION VI: Disease Glycomes

16. Cancer Glycomics

17. An Introduction to Human Disorders of Glycosylation

18. Summary

Details

No. of pages:
512
Language:
English
Copyright:
© 2009
Published:
Imprint:
Academic Press
eBook ISBN:
9780080920054
Print ISBN:
9780123736000

About the editors

Richard Cummings

Affiliations and Expertise

Emory University School of Medicine, Atlanta, GA, USA

J. Pierce

Affiliations and Expertise

University of Georgia, Athens, USA

Reviews

"Overall, this book is well presented; each chapter contains very valuable figures, an up-to-date bibliography, and tables and charts including 22 color plates at the end of the book. The subject index is useful for fast orientation in the numerous topics discussed in the book. A remarkable feature of this book is very wide range of high_ lighting scientific directions that currently unite in glycomics. This book will no doubt serve as an excellent comprehensive overview and will be handy reference book for scientists and teachers in glycobiology, biochemistry, molecular biology, biotechnology, and medicine."--Biochemistry 2010, Volume 75. No. 8, pp. 1064-65

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