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The Handbook of Glycomics provides the first comprehensive overview of the emerging field of glycomics, defined as the study of all complex carbohydrates in an organism or cell ("the glycome"). Beginning with analytic approaches and bioinformatics, this work provides a detailed discussion of relevant databases, data integration, and analysis. It then moves on to a discussion of specific model organism and pathogen glycomes followed by therapeutic approaches to human disorders of glycosylization. Structure and function of glycomes are included along with state-of-the-art technologies and systems approaches to the analysis of glycans.
- Synthesizes contributions from experts in biology, chemistry, bioinformatics, biotechnology, and medicine
- Highlights chapters devoted to chemical synthesis, cancer glycomics and immune cell glycomics
- Includes discussions of proteomics, mass spectrometry, NMR, array technology, and transcriptomics analytic approaches
biology researchers working in genomics, proteomics, systems biology, bioinformatics and novel therapeutics; glycobiology investigators; students in related areas
Introduction to Glycomics
SECTION 1: Glycoconjugate Structural Analysis 1. Glycoproteomics: N-glycan Analysis 2. Glycoproteomics: O-glycan Analysis 3. Glycosaminoglycans 4. Isotopic Labeling of Glycans for Quantitative Glycomics SECTION II: Glycotranscriptomics 5. Glycotranscriptomics SECTION III: Protein-Glycan Interactions 6. Glycan Arrays 7. Chromatographic and Mass Spectrometric Techniques
SECTION IV: Glycobioinformatics
8. Integration of Glycomics Knowledge and Data
9. KEGG GLYCAN for integrated analysis of pathways, genes, and glycan structures
10. European Glycomics Portal SECTION V: Glycomes
11. Glycomics of the Immune System
12. Mouse and Human
15. Parasitic Worms
SECTION VI: Disease Glycomes
16. Cancer Glycomics
17. An Introduction to Human Disorders of Glycosylation
- No. of pages:
- © Academic Press 2009
- 15th September 2009
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Emory University School of Medicine, Atlanta, GA, USA
University of Georgia, Athens, USA
"Overall, this book is well presented; each chapter contains very valuable figures, an up-to-date bibliography, and tables and charts including 22 color plates at the end of the book. The subject index is useful for fast orientation in the numerous topics discussed in the book. A remarkable feature of this book is very wide range of high_ lighting scientific directions that currently unite in glycomics. This book will no doubt serve as an excellent comprehensive overview and will be handy reference book for scientists and teachers in glycobiology, biochemistry, molecular biology, biotechnology, and medicine." --Biochemistry 2010, Volume 75. No. 8, pp. 1064-65
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