Handbook of Epigenetics

Handbook of Epigenetics

The New Molecular and Medical Genetics

3rd Edition - September 1, 2022

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  • Editor: Trygve Tollefsbol
  • Hardcover ISBN: 9780323919098

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Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.

Key Features

  • Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics
  • Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine
  • Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout
  • Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction
  • Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation


Researchers working in genetics, biology, molecular biology, pharmaceutical science, and clinical therapy; university researchers, pharmaceutical company and biotechnology researchers interested in drug development and therapies. Advanced undergraduate and graduate students; clinicians

Table of Contents

  • 1. Epigenetics Overview

    SECTION I: Molecular Mechanisms of Epigenetics
    2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development
    3. Mechanisms of Histone Modification
    4. The Epigenetics of Non-coding RNA
    5. Prions and Prion-like Phenomena in Epigenetic Inheritance
    6. Higher-order Chromatin Organization in Diseases
    7. Polycomb-group Proteins and Epigenetic Control of Gene Activity

    SECTION II: Methods in Epigenetics
    8. Methods for Assessing DNA Cytosine Modifications Genome-wide
    9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome
    10. Techniques for Genome-wide Expression of Non-coding RNA
    11. Computational Epigenetics

    SECTION III: Model Organisms of Epigenetics
    12. Epigenetics of Lower Organisms
    13. Drosophila Epigenetics
    14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies
    15. Plant Epigenomics

    SECTION IV: Factors Influencing Epigenetic Changes
    16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions
    17. Epigenetic Biomarkers
    18. Transposable elements shaping the epigenome 
    19. Metabolic Regulation of DNA Methylation in Mammalian Cells
    20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications
    21. Epigenetics, Stem Cells and Cellular Differentiation
    22. Regeneration Epigenetics
    23. Epigenetics of X-chromosome Inactivation
    24. Epigenetics of Memory Processes
    25. Transgenerational Epigenetics
    26. DNA Methylation Clocks in Age-related Disease

    SECTION V: Evolutionary Epigenetics
    27. Evolution of Epigenetic Mechanisms in Plants
    28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation   
    29. Adaptive Evolution and Epigenetics

    SECTION VI: Epigenetic Epidemiology
    30. Epigenetics of Livestock Breeding
    31. Nutritional Epigenetics and Metabolic Syndrome
    32. Epigenetics of Drug Addiction
    33. Environmental Influence of Epigenetics
    34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease
    35. Population Pharmacoepigenomics

    SECTION VII: Epigenetics and Human Disease
    36. Cancer Epigenetics
    37. The Role of Epigenetics in Autoimmune Disorders
    38. Epigenetics of Brain Disorders
    39. The Epigenetics of Metabolic Diseases
    40. Imprinting Disorders in Humans

    SECTION VIII: Epigenetic Therapy
    41. DNA Demethylating Agents in Clinical Medicine
    42. Clinical Applications of Histone Deacetylase Inhibitors
    43. Combination Epigenetic Therapy

    SECTION XI: The Future of Epigenetics
    44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research

Product details

  • No. of pages: 870
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323919098

About the Editor

Trygve Tollefsbol

Trygve Tollefsbol
Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Affiliations and Expertise

Professor of Biology and Senior Scientist, Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center; Comprehensive Diabetes Center, University of Alabama at Birmingham (UAB), USA

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