Handbook of Epigenetics

Handbook of Epigenetics

The New Molecular and Medical Genetics

1st Edition - September 17, 2010

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  • Editor: Trygve Tollefsbol

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Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.

Key Features

  • Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications
  • Integrates methods and biological topics with basic and clinical discoveries
  • Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders


Genetic, genomic, molecular biology, cell biology, regenerative medicine and tissue engineering researchers; disease-specific researchers and clinicians studying cancer and immunological, neurological, and metabolic disorders; environmental scientists; evolutionary biologists; graduate students, postdoctoral fellows/research associates in these areas; pharmaceutical and biotechnology researchers interested in drug development

Table of Contents

  • 1. Epigenetics: The New Science of Genetics

    SECTION I: Molecular Mechanisms of Epigenetics

    2. Mechanisms of DNA Methylation, Methy-CpG Recognition, and Demethylation in Mammals

    3. Mechanisms of Histone Modifications

    SECTION II: Additional Epigenetic Processes

    4. The Epigenetics of Non-coding RNA

    5. Prions and Prion-like Phenomena in Epigenetic Inheritance

    6. Chromosomal Position Effects and Gene Variegation: Impact in Pathologies

    7. Polycomb Mechanisms and Epigenetic Control of Gene Activity

    SECTION III: Epigenetic Technology

    8. Analysis of Gene-specific DNA Methylation

    9. Methods for Assessing Genome-wide DNA Methylation

    10. Methylation of Lysine-9 of Histone H3: Role in Heterochromatin Modulation and Tumorigenesis

    11. Chromatin Modifications Distinguish Genomic Features and Physical Organization of the Nucleus

    12. Assessing Epigenetic Information

    SECTION IV: Model Organisms of Epigenetics

    13. Epigenetics of Eukaryotic Microbes

    14. Drosophila Epigenetics

    15. Mouse Models of Epigenetic Inheritance

    16. Epigenetic Regulatory Mechanisms in Plants

    SECTION V: Metabolism and Epigenetics
    17. Metabolic Regulation of DNA Methylation in Mammals

    18. Dietary and Metabolic Compounds Affecting Chromatin Dynamics/Remodeling 

    SECTION VI: Functions of Epigenetics

    19. Epigenetics, Stem Cells and Cellular Differentiation

    20. Epigenetic Basis of Skeletal Muscle Regeneration

    21. Epigenetics of X Chromosome Inactivation

    22. Genomic Imprinting

    23. Epigenetics of Memory Processes

    24. Transgenerational Epigenetics

    25. Aging Epigenetics

    SECTION VII: Evolutionary Epigenetics
    26. Epigenetics in Adaptive Evolution and Development

    SECTION VIII: Epigenetic Epidemiology

    27. The Effects of Diet on Epigenetic Processes

    28. Environmental Agents and Epigenetics

    29. Impact of Microbial Infections on the Human Epigenome and Carcinogenesis

    30. DNA Methylation Profiles in the 5’-Upstream Region of the Human FMR1 Promoter and in an Adenovirus Transgenome

    31. Population Pharmacoepigenomics

    SECTION IX: Epigenetics and Human Disease

    32. Cancer Epigenetics

    33. The Role of Epigenetics in Immune Disorders

    34. Epigenetics of Brain Disorders

    35. Complex Metabolic Syndromes and Epigenetics

    36. Imprinting Disorders in Humans

    SECTION X: Epigenetic Therapy

    37. Clinical Applications of Histone Deacetylase Inhibitors


Product details

  • No. of pages: 638
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: September 17, 2010
  • Imprint: Academic Press

About the Editor

Trygve Tollefsbol

Trygve Tollefsbol
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.

Affiliations and Expertise

Distinguished Professor of Biology Senior Scientist, O’Neal Comprehensive Cancer Center Senior Scientist, Integrative Center for Aging Research Senior Scientist, Comprehensive Diabetes Center Senior Scientist, Nutrition Obesity Research Center Senior Scientist, University Wide Microbiome Center Director, Cell Senescence Culture Facility University of Alabama at Birmingham, AL, USA

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