Handbook of Developmental Neurotoxicology

Handbook of Developmental Neurotoxicology

2nd Edition - January 4, 2018

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  • Editors: William Slikker, Jr., Merle G. Paule, Cheng Wang
  • eBook ISBN: 9780128093948
  • Hardcover ISBN: 9780128094051

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Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience.

Key Features

  • Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition
  • Contains new chapters that focus on subjects recent to the field
  • Includes well-illustrated material, with diagrams, charts, and tables
  • Contains compelling case studies and chapters written by world experts


Neurotoxicologists, neurologists, neuroscientists, toxicologists, graduate students, developmental biologists, pharmacologists, post-doctoral fellows, and researchers in biological and biomedical sciences

Table of Contents

    An Introductory Overview: Cellular and Molecular Morphogenesis of the Nervous System
      Cheng Wang
    1. Brain Morphogenesis and Developmental Neurotoxicology
      Karl F. Jensen and Jeanene K. Olin
    2. Neural Cell Adhesion Molecules in Normal and Abnormal Neural Development
      Cheng Wang
    3. Neurite Development and Neurotoxicity
      Zhen He, Sherry Ferguson, Tucker A. Patterson and Merle G. Paule
    4. Myelin: Structure, Function, Pathology and Targeted Therapeutics
      Joseph Hanig and Geeta Negi

    An Introductory Overview
      William Slikker Jr.
    5. Neurotrophic Factors
      Jimcy Platholi and Francis S. Lee
    6. Serotonin Signaling as a Target for Craniofacial Embryotoxicity
      Robert M. Greene and Michele M. Pisano
    7. Neurotoxic and neurotrophic effects of GABAergic agents on the developing brain
      Julia M. Gohlke
    8. Neural stem cell biology and application to developmental neurotoxicity assessment
      Fang Liu and Cheng Wang
    9. Apoptosis as a Mechanism of Developmental Neurotoxicity
      Pamela J. Lein, Suangsuda Supasai and Michelle Guignet
    10. Periods of Susceptibility:  Interspecies Comparison of Developmental Milestones during Ontogenesis of the Central Nervous System
      John M. DeSesso and Amy Lavin Williams
    11. Modeling the Neurovascular Unit in vitro and in silico
      Katerine S. Saili, Todd J. Zurlinden and Thomas B. Knudsen
    12. Zebrafish Models of Developmental Biology and Toxicology
      Courtney Roper and Robert L. Tanguay
    13. Using Caenorhabditis elegans to Study Neurotoxicity
      Margaret M. Sedensky and Philip G. Morgan

    An Introductory Overview: Synaptogenesis and Neurotransmission
      Cheng Wang
    14. Human 3D in vitro Models for Developmental Neurotoxity
      Leah Smirnova and Thomas Hartung
    15. Ontogeny of Monoamine Neurotransmitters
      Sumit Sarkar, Syed Z. Imam and Jennifer L. Walters
    16. Developmental Toxicity within the Central Cholinergic Nervous System
      David A. Jett, Michelle Guignet, Suangsuda Supasai and Pamela J. Lein
    17. Ontogeny of Second Messenger Systems
      Syed Z. Imam, Hector Rosas-Hernandez, Elvis Cuevas, Susan M. Lantz, Sumit Sarkar, Syed F. Ali and Merle G. Paule
    18. The NMDA Receptors: Physiology and Neurotoxicology in the Developing Brain
      Qiang Gu

    An Introductory Overview: Nutrient and Chemical Disposition
      William Slikker Jr.
    19. Physiologically Based Pharmacokinetic (PBPK) Models
      Jeffrey W. Fisher, Xiaoxia Yang and Charles Timchalk
    20. Blood-Brain Barrier: Physiological and Functional Considerations
      Hector Rosas-Hernandez, Elvis Cuevas, Susan M. Lantz, Syed Z. Imam, Merle G. Paule and Syed F. Ali
    21. Toxicological Mechanisms of Engineered Nanomaterials: Role of Material Properties in Inducing Different Biological Responses
      R. L. Salisbury, R. Agans, M. E. Huddleston, A. Snyder, Alexandra Mendlein and Saber Hussain
    22. Food and Nutrient Exposure Throughout the Life Span: How Does What We Eat Translate into Exposure, Deficiencies, and Toxicities?
      Keli M. Hawthorne
    23. The Microbiome Gut-Brain Axis
      Carl E. Cerniglia
    24. Drug and Chemical Contaminants in Breast Milk: Effects on Neurodevelopment of the Nursing Infant
      Tom Leibson, Prateek Lala and Shinya Ito

    An Introductory Overview: Behavioral Assessment
      Merle G. Paule
    25. Behavioral Phenotyping in Developmental Neurotoxicology – Simple Approaches using Unconditioned Behaviors in Rodents
      Devon L. Graham, Jerrold S. Meyer and Gregg D. Stanwood
    26. Psychometric Tools to Study Cognition, Sensory Functioning and Social Behavior in Infant and Adolescent Nonhuman Primates
      Thomas M. Burbacher and Kimberly S. Grant
    27. Automated assessment of cognitive function in nonhuman primates
      John C. Talpos and Merle G. Paule
    28. Determining the validity of pre-clinical behavioral assessments for extrapolation to a clinical setting
      John C. Talpos and John J. Chelonis
    29. Behavioral Outcome as a Primary Organizing Principle for Mechanistic Data in Developmental Neurotoxicity
      Christina Sobin and Mari Golub

    An Introductory Overview: Clinical Assessment and Epidemiology
      Jan M. Friedman
    30. Evaluation of the Human Newborn Infant
      Lilly Bogičević, Marjolein Verhoeven and Anneloes van Baar
    31. Neuropsychological Assessment of Children in Studies of Developmental Neurotoxicity
      David C. Bellinger and Johanna Calderon
    32. Neurodevelopmental Assessment of the Older Infant and Child
      William J. Barbaresi and Julie Bickel
    33. Longitudinal Studies of the Effects of Prenatal Cocaine Exposure on Development and Behavior
      Gale A. Richardson and Nancy L. Day
    34. Assessment of Case Reports and Clinical Series
      Jan M. Friedman

    An Introductory Overview: Specific Neurotoxic Syndromes
      Merle G. Paule
    35. Fetal Minamata Disease: A Human Episode of Congenital Methylmercury Poisoning
      Alessandra Antunes dos Santos, Louis W. Chang, Grace Liejun Guo and Michael Aschner
    36. The Developmental Neurotoxicity of Cadmium
      Ashley J. Malin and Robert O. Wright
    37. Developmental Neurotoxicology of Lead –  Neurobehavioral and Neurological Impacts
      Stephen M. Lasley
    38. Fetal Alcohol Spectrum Disorder
      Irena Nulman, Talya Shulman and Feiyuan Liu
    39. Developmental Neurotoxicity of Nicotine and Tobacco
      Edward D. Levin and Yael Abreu-Villaça
    40. Developmental Neurobehavioral Neurotoxicity of Insecticides
      Yael Abreu-Villaça and Edward D. Levin
    41. Developmental Exposure to Polychlorinated Biphenyls Induces Deficits in Inhibitory Control and May Enhance Substance Abuse Risk
      Mellessa M. Miller and Helen J K Sable
    42. Developmental Neurotoxicity of General Anesthetics
      Jennifer L. Walters and Merle G. Paule
    43. Maternal Drug Abuse and Adverse Effects on Neurobehavior of Offspring
      Diana Dow-Edwards
    44. Developmental Neurotoxicology of Antiepileptic Drugs
      Jocelyn M. Lutes, Jolene E. Borchelt, Patricia A. Janulewicz and Jane Adams

    An Introductory Overview:  Risk Assessment
      William Slikker Jr.
    45. Current Approaches to Risk Assessment for Developmental Neurotoxicity
      Susan L. Makris and Andrew D. Kraft
    46. Animal/Human Concordance
      Larry P. Sheets and William Slikker Jr.
    47. Physiologically based pharmacokinetic models in the risk assessment of developmental neurotoxicants
      Kannan Krishnan
    48. Application of Quantitative dose response data in risk assessment and the incorporation of high throughput data
      John C. Lipscomb

Product details

  • No. of pages: 616
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: January 4, 2018
  • Imprint: Academic Press
  • eBook ISBN: 9780128093948
  • Hardcover ISBN: 9780128094051

About the Editors

William Slikker, Jr.

William Slikker, Jr.
Dr. William Slikker, Jr. is the director of FDA’s National Center for Toxicological Research (NCTR). He received his Ph.D. in pharmacology and toxicology from the University of California at Davis. Dr. Slikker holds adjunct professorships in the Department of Pediatrics, as well as the Department of Pharmacology and Toxicology at the University of Arkansas for Medical Sciences. He has held committee chairmanships or elected offices in several scientific societies including the Teratology Society (serving as president) and the American Society for Pharmacology and Experimental Therapeutics (chair, Developmental Pharmacology Section and member, Program Committee). Dr. Slikker is also the co-founder and past president of the MidSouth Computational Biology and Bioinformatics Society. He is currently associate editor for NeuroToxicology and associate editor for the “Environmental Health” section of Experimental Biology and Medicine. He is the past president of The Academy of Toxicological Sciences and the Society of Toxicology. He is a recipient of the 2014 George H. Scott Memorial Award from The Toxicology Forum and was invited to present the Warkany Lecture at the 2015 annual meeting of the Teratology Society. In early 2019, the Academy of Toxicological Sciences selected Dr. Slikker to receive the prestigious Mildred S. Christian Career Achievement Award. The Society for Birth Defects Research and Prevention selected Dr. Slikker to be the recipient of the 2022 Edward W. Carney Distinguished Service Award. Dr. Slikker has authored or co-authored over 380 publications in the areas of transplancental pharmacokinetics, developmental neurotoxicology, neuroprotection, systems biology, and risk assessment. Dr. Slikker’s recent research has highlighted the concern for thousands of infants and toddlers who undergo longer-duration general anesthesia. He has performed research with his team and published over 25 peer-reviewed papers outlining the issue of brain-cell death and cognitive-function deficits in animal models that may result from several hours of anesthesia at a critical time of development. He has also, with the use of in vitro and in vivo techniques in rodents and nonhuman primates, defined possible mechanisms of toxicity and protective pathways to prevent the detrimental effects of general anesthesia. Through these and related scientific contributions, he has identified and characterized a host of minimally invasive biomarkers of neurotoxicity including the use of preclinical imaging (MRI, MicroPET/CT), genomic and lipidomic analysis, and modeling approaches to characterize and quantify adult and developmental neurotoxicity. He has also served on several national/international advisory panels for ILSI, HESI, CIIT, EPA, NIEHS, NAS, NIH and WHO.

Affiliations and Expertise

National Center for Toxicological Research, Jefferson, US FDA, AR, USA

Merle G. Paule

Dr. Paule received his B.S. in Biochemistry and his Ph.D. in Pharmacology and Toxicology at the University of California at Davis. In 1983 he began work at the FDA’s National Center for Toxicological Research in Jefferson, Arkansas, where he remains today. He attained certification as one of FDA’s Senior Biomedical Research Scientists in 2000 and in 2005 became the Director of the Division of Neurotoxicology at NCTR. Dr. Paule has played a major role in developing an automated system for monitoring multiple complex brain functions in nonhuman primates, children, and rodents. Utilization of similar or identical behavioral tasks across species serves to facilitate the interspecies extrapolation of exposure data and, thus, the risk assessment process. He is past President of the Behavioral Toxicology Society, the Neurobehavioral Teratology Society and the Neurotoxicology Specialty Section of the Society of Toxicology and Associate Editor for the journals NeuroToxicology and Neurotoxicology and Teratology. Dr. Paule has published over 225 research articles and 30 book chapters and holds Adjunct Professorships at the University of Arkansas for Medical Sciences in the Departments of Pharmacology and Toxicology and in Pediatrics. He is an elected Fellow in the Academy of Toxicological Sciences and in the International Behavioral Neuroscience Society.

Affiliations and Expertise

Division of Neurotoxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA

Cheng Wang

Cheng Wang
Cheng Wang, M.D., Ph.D. is a Senior Scientist at the National Center for Toxicological Research (NCTR)/US Food and Drug Administration (FDA). He is also an Adjunct Faculty member in the Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences (UAMS). Dr. Wang is the P.I. of protocols (grants) supported by the NCTR/FDA, National Toxicology Program and NICHD. He is currently responsible for leading a research team that provides unique and highly specialized skills in neural toxicology, pharmacology, systems biology and stem cell biology research. Dr. Wang has published more than 80 peer-reviewed research articles in prestigious journals and 20 book chapters. Dr. Wang is a Co-Editor-in-Chief of the book entitled “Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms” and “Neural Cell Biology”. He also serves as Editor-in-Chief for Journal of Evolving Stem Cell Research (JESR) and Global Journal of Anesthesiology. Dr. Wang was awarded the Outstanding Performance Award at the Society of Toxicology 44th Annual Meeting and the 2007 FDA Scientific Achievement Award for Excellence in Laboratory Science. He also was awarded a 2008 FDA Group Recognition Award for his participation in the Pediatric Anesthesia Research Group. Research Interests Neural Stem Cell Biology Application of Systems Biology in Neurotoxicological Studies during Development Activity-induced Synaptic Plasticity and Neural Cell Adhesion Molecule Potential Pediatric Anesthetic-induced Neural Cell Death and the Potential Role of Neurotransmission (Mechanistic Studies) Mitochondrial DNA Damage and Expression Levels of DNA Repair Enzymes

Affiliations and Expertise

Division of Neurotoxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA

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