Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

2nd Edition - March 28, 2018

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  • Editor: Herbert B. Newton
  • Hardcover ISBN: 9780128121009
  • eBook ISBN: 9780128121016

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Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed.

Key Features

  • Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors
  • Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors
  • Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods
  • Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors


Neuroscientists, neurobiologists, neuro-oncologists, neurologists, post-doctoral fellows, researchers, graduate students in biological and biomedical sciences

Table of Contents

    1. Overview of Brain Tumor Epidemiology and Histopathology
    2. Clinical Pharmacology of Brain Tumor Chemotherapy
    3. Antiepileptic drugs and chemotherapy: Potential interactions and impact on treatment of patients with cancer
    4. Brain Tumor Models for Cancer Therapy
    5. Genomics and proteomics in neuro-oncology
    6. Chemotherapy Resistance
    7. Clinical Trial Design and Implementation in Neuro-Oncology
    8. Biology of the Blood-Brain and Blood-Brain Tumor Barriers

    9. Intra-arterial Chemotherapy
    10. Blood-Brain Barrier Disruption Chemotherapy
    11. Interstitial Chemotherapy and Polymer-Drug Delivery
    12. Intratumoral Chemotherapy and Convection-Enhanced Delivery
    13. Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue in Brain Tumors
    14. CSF Dissemination of Primary Brain Tumors
    15. Gene/Viral Treatment Approaches for Malignant Brain Cancer
    16. Nanoparticles as Therapeutic Agents for Brain Tumors

    17. Overview of Molecular Genetics of Brain Tumors
    18. Cell Cycle Regulation
    19. Targeting cell cycle proteins in brain cancer
    20. Apoptosis Pathways and Chemotherapy in Brain Tumors
    21. Growth Factor Signaling Pathways and Targeted Therapy
    22. Targeting the RAS-RAF-MEK-ERK Signaling Pathway in Gliomas
    23. PI3-kinase, Akt, mTOR and Treatment
    24. Scatter Factor/HGF and C-MET in Glioblastoma
    25. Targeting the sonic hedgehog pathway in brain cancers: Advances, limitations, and future directions
    26. Angiogenesis and angiogenesis inhibitors in brain tumors
    27. Bevacizumab and Brain Tumors
    28. Histone Deacetylase Inhibitors as Therapeutic Agents

    29. Historial and conventional chemotherapy approaches for high grade astrocytomas
    30. The use of temozolomide for chemo-radiation and adjuvant therapy of high-grade gliomas
    31. Molecular Treatment of High-Grade Glioma
    32. Chemotherapy of Low-Grade Astrocytomas
    33. Chemotherapy of Oligodendrogliomas
    34. Chemotherapy of Primary Central Nervous System Lymphoma
    35. Chemotherapy for Medulloblastoma in Adults
    36. Chemotherapy of Adult Ependymoma
    37. Chemotherapy for  Glioneuronal Tumors
    38. Medical therapy of Schwannomas
    39. Chemotherapy of Pineal Parenchymal Tumors
    40. Chemotherapy of Meningiomas
    41. Chemotherapy of Brain Metastases

    42. Chemotherapy of Pediatric Low-Grade Gliomas
    43. Chemotherapy of Pediatric High-Grade Gliomas
    44. Chemotherapy for Medulloblastoma
    45. Chemotherapy of Brainstem Gliomas
    46. Germ Cell Tumors
    47. Chemotherapy of Ependymoma – Childhood
    48. Chemotherapy for CNS Atypical Teratoid/Rhabdoid Tumor
    49. Chemotherapy of Central Nervous System Primitive Neuro-Ectodermal Tumors
    50. Pediatric Choroid Plexus Carcinoma: Current Management and Future Directions

    51. The Immune Response to Glioblastoma:  Overview and Focus on Checkpoint Blockade
    52. Blockade of the Checkpoint Inhibitor Pathways and Activated T-cell Therapy in Brain Tumors
    53. Overview of Dendritic Cell Vaccines for Brain Tumors
    54. Overview of Vaccine Strategies against Epidermal Growth Factor Receptor in Brain Tumors
    55. Overview of CNS Vaccines – Pediatrics

    56. Issues in Response Assessment of Brain Tumor Chemotherapy
    57. Pseudoprogression in Neuro-Oncology:  Overview, Pathophysiology, and Interpretation
    58. Response assessment in neuro-oncology (RANO): An update
    59. Immunotherapy Response Assessment in Neuro-Oncology (iRANO)
    60. Quality of Life in Neuro-Oncology
    61. Neuropsychology of Chemotherapy in Brain Tumor Patients

Product details

  • No. of pages: 848
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: March 28, 2018
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128121009
  • eBook ISBN: 9780128121016

About the Editor

Herbert B. Newton

Herbert B. Newton
Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Advent Health Cancer Institute and Advent Health Orlando Campus. He recently retired as Professor of Neurology and Neurosurgery at the Ohio State University Medical Center and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York, and since then had been in academic Neuro-Oncology for over 25 years. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of ten textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 18 years.

Affiliations and Expertise

Director, Neuro-Oncology Center, Medical Director, CNS Oncology Program, Advent Health Cancer Institute, Advent Health Orlando, Campus & Advent Health Medical Group, Professor of Neurology, UCF School of Medicine, Orlando, FL, USA

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