Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy - 2nd Edition - ISBN: 9780128121009, 9780128121016

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

2nd Edition

Editors: Herbert B. Newton
eBook ISBN: 9780128121016
Hardcover ISBN: 9780128121009
Imprint: Academic Press
Published Date: 16th April 2018
Page Count: 852
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Description

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches.

As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed.

Key Features

  • Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors
  • Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors
  • Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods
  • Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Readership

Neuroscientists, neurobiologists, neuro-oncologists, neurologists, post-doctoral fellows, researchers, graduate students in biological and biomedical sciences

Table of Contents

SECTION I.  PHARMACOLOGICAL AND CLINICAL APPLICATIONS
1. Overview of Brain Tumor Epidemiology and Histopathology
2. Clinical Pharmacology of Brain Tumor Chemotherapy
3. Antiepileptic drugs and chemotherapy: Potential interactions and impact on treatment of patients with cancer
4. Brain Tumor Models for Cancer Therapy
5. Genomics and proteomics in neuro-oncology
6. Chemotherapy Resistance
7. Clinical Trial Design and Implementation in Neuro-Oncology
8. Biology of the Blood-Brain and Blood-Brain Tumor Barriers

SECTION II.  INNOVATIVE CHEMOTHERAPY DELIVERY
9. Intra-arterial Chemotherapy
10. Blood-Brain Barrier Disruption Chemotherapy
11. Interstitial Chemotherapy and Polymer-Drug Delivery
12. Intratumoral Chemotherapy and Convection-Enhanced Delivery
13. Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue in Brain Tumors
14. CSF Dissemination of Primary Brain Tumors
15. Gene/Viral Treatment Approaches for Malignant Brain Cancer
16. Nanoparticles as Therapeutic Agents for Brain Tumors

SECTION III.  MOLECULAR BIOLOGY AND MOLECULAR THERAPEUTICS
17. Overview of Molecular Genetics of Brain Tumors
18. Cell Cycle Regulation
19. Targeting cell cycle proteins in brain cancer
20. Apoptosis Pathways and Chemotherapy in Brain Tumors
21. Growth Factor Signaling Pathways and Targeted Therapy
22. Targeting the RAS-RAF-MEK-ERK Signaling Pathway in Gliomas
23. PI3-kinase, Akt, mTOR and Treatment
24. Scatter Factor/HGF and C-MET in Glioblastoma
25. Targeting the sonic hedgehog pathway in brain cancers: Advances, limitations, and future directions
26. Angiogenesis and angiogenesis inhibitors in brain tumors
27. Bevacizumab and Brain Tumors
28. Histone Deacetylase Inhibitors as Therapeutic Agents

SECTION IV.  CHEMOTHERAPY FOR SPECIFIC TUMORS – ADULTS
29. Historial and conventional chemotherapy approaches for high grade astrocytomas
30. The use of temozolomide for chemo-radiation and adjuvant therapy of high-grade gliomas
31. Molecular Treatment of High-Grade Glioma
32. Chemotherapy of Low-Grade Astrocytomas
33. Chemotherapy of Oligodendrogliomas
34. Chemotherapy of Primary Central Nervous System Lymphoma
35. Chemotherapy for Medulloblastoma in Adults
36. Chemotherapy of Adult Ependymoma
37. Chemotherapy for  Glioneuronal Tumors
38. Medical therapy of Schwannomas
39. Chemotherapy of Pineal Parenchymal Tumors
40. Chemotherapy of Meningiomas
41. Chemotherapy of Brain Metastases

SECTION V.  CHEMOTHERAPY FOR SPECIFIC TUMORS – PEDIATRICS
42. Chemotherapy of Pediatric Low-Grade Gliomas
43. Chemotherapy of Pediatric High-Grade Gliomas
44. Chemotherapy for Medulloblastoma
45. Chemotherapy of Brainstem Gliomas
46. Germ Cell Tumors
47. Chemotherapy of Ependymoma – Childhood
48. Chemotherapy for CNS Atypical Teratoid/Rhabdoid Tumor
49. Chemotherapy of Central Nervous System Primitive Neuro-Ectodermal Tumors
50. Pediatric Choroid Plexus Carcinoma: Current Management and Future Directions

SECTION VI.  IMMUNOTHERAPY OF BRAIN TUMORS
51. The Immune Response to Glioblastoma:  Overview and Focus on Checkpoint Blockade
52. Blockade of the Checkpoint Inhibitor Pathways and Activated T-cell Therapy in Brain Tumors
53. Overview of Dendritic Cell Vaccines for Brain Tumors
54. Overview of Vaccine Strategies against Epidermal Growth Factor Receptor in Brain Tumors
55. Overview of CNS Vaccines – Pediatrics

SECTION VII.  RESPONSE ASSESSMENT, QUALITY OF LIFE, AND NEUROPSYCHOLOGY
56. Issues in Response Assessment of Brain Tumor Chemotherapy
57. Pseudoprogression in Neuro-Oncology:  Overview, Pathophysiology, and Interpretation
58. Response assessment in neuro-oncology (RANO): An update
59. Immunotherapy Response Assessment in Neuro-Oncology (iRANO)
60. Quality of Life in Neuro-Oncology
61. Neuropsychology of Chemotherapy in Brain Tumor Patients

Details

No. of pages:
852
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
eBook ISBN:
9780128121016
Hardcover ISBN:
9780128121009

About the Editor

Herbert B. Newton

Herbert B. Newton

Dr. Newton is currently the Director of the Neuro-Oncology Center and CNS Oncology Program at the Florida Hospital Cancer Institute and Florida Hospital Orlando. He recently retired as a Professor of Neurology, Neurosurgery, & Oncology at the Wexner Medical Center at Ohio State University and the James Cancer Hospital, and was the holder of the Esther Dardinger Endowed Chair in Neuro-Oncology. He trained in Neuro-Oncology with Drs. Jerome Posner and William Shapiro at Memorial Sloan-Kettering Cancer Center in New York City, and since then had been in academic Neuro-Oncology for over 25 years – until his retirement. He has published more than 220 peer-reviewed articles and book chapters, and is the Chief Editor or Co-Editor of eight textbooks in the field of Neurology and Neuro-Oncology. In addition, he has been listed as a Best Doctor (Neurology) and Top Doctor for Cancer (Neuro-Oncology) for the past 16 years.

Affiliations and Expertise

Director, Neuro-Oncology Center, Medical Director, CNS Oncology Program, Florida Hospital Cancer Institute and Florida Hospital Orlando, Orlando, FL, USA

Ratings and Reviews