Handbook of Biomaterials Biocompatibility

Handbook of Biomaterials Biocompatibility

1st Edition - June 16, 2020

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  • Editor: Masoud Mozafari
  • eBook ISBN: 9780081029688
  • Paperback ISBN: 9780081029671

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Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology.

Key Features

  • Reviews the fundamental theories and challenges of biomaterials biocompatibility, including an overview of the standards and regulations
  • Provides an overview on the cellular and molecular mechanisms involved in host responses to biomaterials
  • Systematically looks at cellular response and tissue response to a wide range of biomaterials, including polymers, metals, ceramics, alloys and nanomaterials


Materials science, regenerative engineering, medicine, medical devices, and nanotechnology, those working in academia, R&D and the clinic

Table of Contents

  • Volume I: An introduction to biocompatibility
    1. Biocompatibility Definition and Issues
    2. Cell-Biomaterials Interactions
    3. Protein Responses to Biomaterials
    4. Macrophages Responses to Biomaterials
    5. Dendritic Cells Responses to Biomaterials
    6. Impact of Biomaterials' Physical Properties on Cellular and Molecular Responses
    7. Impact of Biomaterials' Mechanics on Cellular and Molecular Responses
    8. Impact of Biomaterials' Chemistry on Cellular and Molecular Responses
    9. Cell-Biomaterials Interactions: The Role of Growth Factors
    10. Cell-Biomaterials Interactions: The Role of Ligand Functionalization
    11. Methods of Testing Cell-Biomaterials Interactions
    12. In vivo Models for Biomaterials
    13. Clinical impacts of biocompatibility: What surgeons ought to know
    14. Standardization and Regulation of Biomaterials

    Volume II: Cellular Response to Biomaterials
    15. Cellular Response to Natural Polymers
    16. Cellular Response to Synthetic Polymers
    17. Cellular Response to Composite Polymers
    18. Cellular Response to Zirconia
    19. Cellular Response to Alumina
    20. Cellular Response to Carbon-family materials
    21. Cellular Response to Calcium phosphate cements
    22. Cellular Response to Bioactive glasses and Glass-Ceramics
    23. Cellular Response to Titanium Alloys
    24. Cellular Response to Co-Based Alloys
    25. Cellular Response to Stainless Steels
    26. Cellular Response to Nano-Biomaterials

    Volume III: Tissue Response to Biomaterials
    27. Central Nervous System Responses to Biomaterials
    28. Peripheral Nervous System Responses to Biomaterials
    29. Cardiac Responses to Biomaterials
    30. Vascular Responses to Biomaterials
    31. Bone Responses to Biomaterials
    32. Tendon and Muscle Responses to Biomaterials
    33. Cartilage Responses to Biomaterials
    34. Pulmonary system Responses to Biomaterials
    35. Gastrointestinal Organs' Responses to Biomaterials
    36. Ocular Responses to Biomaterials
    37. Skin Responses to Biomaterials


Product details

  • No. of pages: 758
  • Language: English
  • Copyright: © Woodhead Publishing 2020
  • Published: June 16, 2020
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780081029688
  • Paperback ISBN: 9780081029671

About the Editor

Masoud Mozafari

Masoud Mozafari
Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafari’s research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals.

Affiliations and Expertise

Research Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada

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