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Handbook of Biologically Active Peptides - 1st Edition - ISBN: 9780123694423, 9780080463797

Handbook of Biologically Active Peptides

1st Edition

Editors: Abba Kastin Abba Kastin
Hardcover ISBN: 9780123694423
eBook ISBN: 9780080463797
Imprint: Academic Press
Published Date: 29th August 2006
Page Count: 1640
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Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine.

The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.

Key Features

*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar. *Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.


Peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists

Table of Contents

Contributors Preface Foreword

I: Plant Peptides Section

  1. 4-kDa Peptide
  2. AtPep1 Peptides
  3. CLAVATA3: A Putative Peptide Ligand Controlling Arabidopsis StemCell
  4. DVL Peptides Are Involved in Plant Development
  5. The POLARIS Peptide
  6. Phytosulfokine
  7. RALF Peptides
  8. ROTUNDIFOLIA4: A Plant-Specifi c Small Peptide
  9. The S-Locus Cysteine-Rich Peptide SCR/SP11
  10. Systemins

II: Bacterial/Antibiotic Peptides Section 11. Cationic Antimicrobial Peptides¡XThe Defensins 12. Cathelicidins: Cationic Host Defense and Antimicrobial Peptides 13. Microcins 14. Peptaibols 15. Nonribosomally Synthesized Microbial Macrocyclic Peptides 16. Lantibiotics 17. The Nonlantibiotic Heat-Stable Bacteriocins in Gram-Positive Bacteria 18. Colicins: Bacterial/Antibiotic Peptides

III: Fungal/Antifungal Peptides Section 19. Fungal Peptides with Antifungal Activity 20. Toxins from Basidiomycete Fungi (Mushroom): Amatoxins, Phallotoxins, and Virotoxins 21. Fungal Peptides with Ribonuclease Activity 22. Fungal Ribosome Inactivating Proteins 23. Peptides and Depsipeptides from Plant Pathogenic Fungi

IV: Invertebrate Peptides Section 24. Insect Diuretic and Antidiuretic Hormones 25. Developmental Peptides: ETH, Corazonin, and PTTH 26. Tachykinins and Tachykinin-Related Peptides in Invertebrates 27. Proctolin in Insects 28. Sulfakinins 29. The Invertebrate AKH/RPCH Family 30. Insect Myosuppressins/FMRFamides and FL/IRFamides/NPFs 31. Allatostatins in the Insects 32. The FXPRLamide (Pyrokinin/PBAN) Peptide Family 33. Insect Pigment Dispersing Factor and Bursicon 34. Crustacean Bioactive Peptides 35. Crustacean Chromatophorotrophins and Hyperglycemic Hormone Peptide Families 36. Molluscan Bioactive Peptides 37. Molluscan Peptides and Reproduction 38. Free-Living Nematode Peptides 39. Parasitic Nematode Peptides

V: Amphibian Peptides Section 40. Amphibian Tachykinins 41. Opioid Peptides from Frog Skin and Bv8-Related Peptides 42. Amphibian Bombesin-Like Peptides 43. Host Defense Peptides from Australian Amphibians: Caerulein and Other Neuropeptides 44. Bradykinin-Related Peptides from Frog Skin 45. The Dermaseptins 46. The Temporins 47. Chromogranins/Secretogranins and Derived Peptides: Insights from the Amphibian Model 48. Sodefrin and Related Pheromones 49. Amphibian Neurohypophysial Peptides 50. Bombinins

VI: Venom Peptides Section 51. Scorpion Venom Peptides 52. Snake Venom Peptides 53. Sea Anemone Venom Peptides 54. Spider Venom Peptides 55. Conus Snail Venom Peptides 56. Insect Venom Peptides 57. Worm Venom Peptides 58. Targets and Therapeutic Properties of Venom Peptides 59. Structure-Function Strategies to Improve the Pharmacological Value of Animal Toxins

VII: Cancer/Anticancer Peptides Section 60. Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Cancer 61. Bombesin-Related Peptides and Neurotensin: Effects on Cancer Growth/Proliferation and Cellular Signaling in Cancer 62. Somatostatin and NPY 63. Bradykinin and Cancer 64. Endothelin 65. Adrenomedullin: An Esoteric Juggernaut of Human Cancers 66. Angiotensin Peptides and Cancer 67. Gastrin and Cancer 68. VIP and PACAP as Autocrine Growth Factors in Breast and Lung Cancer 69. Oxytocin and Cancer 70. Antagonists of Growth Hormone¡VReleasing Hormone (GHRH) in Cancer

VIII: Vaccine Peptides Section 71. Cancer Immunotherapy with Rationally Designed Synthetic Peptides 72. Peptide Vaccines for Cancer Treatment 73. Antiadhesin Synthetic Peptide Consensus Sequence Vaccine and Antibody Therapeutic for Pseudomonas Aeruginosa 74. Peptide Vaccines for Malaria 75. Peptide Vaccine for Otitis Media 76. Peptide Vaccine for Alzheimer¡¦s Disease 77. Peptide Dendrimers as Immunogens

IX: Immunological and Infl ammatory Peptides Section 78. Chemotactic Peptide Ligands for Formylpeptide Receptors Influencing Inflammation 79. Complement-Derived Inflammatory Peptides: Anaphylatoxins 80. Chemokines: A New Peptide Family of Neuromodulators 81. Immune Peptides Related to Dipeptidyl Aminopeptidase IV/CD26 82. RGD-Peptides and Some Immunological Problems 83. Neuropeptides That Regulate Immune Responses 84. Peptides as Targets of T Cell-Mediated Immune Responses 85. The Use of Positional Scanning Synthetic Peptide Combinatorial Libraries to Identify Immunological Relevant Peptides 86. Copolymer 1 and Related Peptides as Immunomodulating Agents 87. CLIP¡XA Multifunctional MHC Class II¡VAssociated Self-Peptide

X: Brain Peptides Section 88. Vasopressin and Oxytocin 89. Thyrotrophin-Releasing Hormone: New Functions for an Ancient Peptide 90. Gonadotrophin Releasing Hormone 91. Brain Somatostatin-Related Peptides 92. Corticotrophin-Releasing Hormone (CRH) Peptide Family 93. Growth Hormone-Releasing Hormone 94. PACAP/VIP 95. Neuropeptide Y 96. Melanocortins 97. Cocaine- and Amphetamine-Regulated Transcript (CART) 98. The Melanin-Concentrating Hormone 99. CCK/Gastrin 100. The Hypocretins (Orexins) 101. Ghrelin 102. Neurotensin 103. Neuromedin U (NMU): Brain Peptide 104. Galanin and GALP Systems in Brain¡XMolecular Pharmacology, Anatomy, and Putative Roles in Physiology and Pathology 105. Brain Tachykinins 106. CGRP and Adrenomedullin in the Brain 107. The RFamide-Related Peptides 108. Apelin: Discovery, Distribution, and Physiological Role 109. Urotensin II and Urotensin II¡VRelated Peptide 110. Brain/B-Type Natriuretic Peptide (BNP) and C-Type Natriuretic Peptide (CNP) 111. Endozepines 112. KiSS-1/Metastin

XI: Endocrine Peptides Section 113. Role of Opioid Peptides in the Local Regulation of Endocrine Glands 114. Role of Tachykinin-Gene-Related Peptides in the Local Regulation of Endocrine Glands 115. Neuropeptide Y and the Regulation of Endocrine Function 116. Effects of PACAP in the Local Regulation of Endocrine Glands 117. Endothelins in the Local Regulation of Endocrine Glands 118. Adrenomedullin and Related Peptides in the Local Regulation of Endocrine Glands 119. Ghrelin in the Local Regulation of Endocrine Glands 120. Atrial Natriuretic Peptide in Local Regulation of Endocrine Glands 121. Galanin, Neurotensin, and Neuromedins in the Local Regulation of Endocrine Glands

XII: Ingestive Peptides Section 122. Neuropeptide Y: A Conductor of the Appetite-Regulating Orchestra in the Hypothalamus 123. Hypothalamic Galanin and Ingestive Behavior: Relation to Dietary Fat, Alcohol, and Circulating Lipids 124. Effects of Melanocortins on Ingestive Behavior 125. CART Peptide and Ingestive Behavior 126. Orexins and Opioids in Feeding Behavior 127. Melanin-Concentrating Hormone 128. Corticotrophin-Releasing Hormone (CRH) and Ingestive Behavior 129. Peptide YY (PYY) and Neuromedin U (NMU): Effects on Ingestive Behavior 130. Ghrelin and Ingestive Behavior 131. Cholecystokinin and Satiety 132. Enterostatin, a Peptide Regulator of Dietary Fat Ingestion 133. Regulation of Feeding Behavior by Glucagonlike Peptide 1 (GLP-1) 134. Role of Amylin and Calcitonin-Gene-Related Peptide (CGRP) in the Control of Food Intake 135. Leptin and the Regulation of Feeding 136. Ingestive Peptides: Insulin

XIII: Gastrointestinal Peptides Section 137. Adrenomedullin in Gastrointestinal Function 138. Calcitonin Gene-Related Peptide and Gastrointestinal Function 139. Peripheral Cholecystokinin 140. Corticotrophin-Releasing Hormone (CRH) Family in the Gastrointestinal System 141. Paneth Cell „´-Defensins 142. Galanin in the Gastrointestinal Tract: Distribution and Function 143. Gastrin 144. Gastrin-Releasing Peptide 145. Glucagonlike Peptides 1 and 2, Enteroglucagon, Glicentin, and Oxyntomodulin 146. Ghrelin 147. Leptin and the Gastrointestinal Tract 148. Motilin 149. Neurotensin in Regulation of Gastrointestinal Functions 150. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) 151. Pancreatic Polypeptide 152. Peptide YY 153. Secretin 154. Somatostatin 155. Somatostatin Analogs in the Gastrointestinal Tract 156. Substance P and Related Tachykinins in the Gastrointestinal Tract 157. TFF (Trefoil Factor Family) Peptides 158. Signaling by Vasoactive Intestinal Peptide in Gastrointestinal Smooth Muscle

XIV: Cardiovascular Peptides Section 159. Adrenomedullin and Its Related Peptides 160. Angiotensin II and Its Related Peptides 161. Bradykinin and Its Related Peptides 162. Calcitonin Gene-Related Peptides 163. Endothelins 164. Ghrelin: Its Therapeutic Potential in Heart Failure 165. Natriuretic Peptides in the Cardiovascular System 166. Urotensin and Its Related Peptides 167. Vasoactive Intestinal Peptide 168. Cardiovascular Peptides: Vasopressin

XV: Renal Peptides Section 169. Renal Effects of Neurohypophyseal Peptides 170. Renal Renin-Angiotensin System 171. Renal Natriuretic Peptide System and Actions of Urodilatin 172. ANP and Its Role in the Regulation of Renal Tubular Transport Processes 173. Adrenomedullin as a Renal Peptide 174. Adrenomedullin 2/Intermedin 175. Renal Endothelin 176. Prolactin and Kidney Function

XVI: Respiratory Peptides Section 177. Therapeutic Potential of Adrenomedullin for Pulmonary Hypertension 178. Endothelin in the Airways 179. PACAP¡¦s Role in Pulmonary Function 180. Tachykinins and Their Receptors in the Lung 181. Vasoactive Intestinal Peptide

XVII: Opioid Peptides Section 182. Proenkephalin-Derived Opioid Peptides 183. Prodynorphin-Derived Opioid Peptides 184. POMC Opioid Peptides 185. Endomorphins as Endogenous Peptides for „f-Opioid Receptor: Their Differences in the Pharmacological and Physiological Characters 186. Casomorphins and Hemorphins¡XOpioid Active Peptides Released by Partial Hydrolysis of Structural Proteins 187. Anti-Opioid Peptides 188. Nociceptin 189. Role of Tachykinins in Spinal Nociceptive Mechanisms and Their Interactions with Opioids 190. Exorphin-Opioid Active Peptides of Exogenous Origin 191. Opioid-Substance P Chimeric Peptides

XVIII: Neurotrophic Peptides Section 192. VIP- and PACAP-Related Neuroprotection 193. Insulin-Like Growth Factor 1 194. Erythropoietin¡XA Hematopoietic Hormone with Emerging Diverse Activities 195. Neuregulins 196. The Neurotrophins

XIX: Blood-Brain Barrier Peptides Section 197. Amino Acid Transport Across the Blood¡VBrain Barrier 198. Oligopeptide Transport at the Blood¡VBrain and Blood¡VCSF Barriers 199. Opiate Peptides and the Blood¡VBrain Barrier 200. Permeability of the Blood¡VBrain Barrier to Neurotrophic Peptides 201. Transport of Basic Peptides at the Blood¡VBrain Barrier 202. Fibroblast Growth Factor and the Blood¡VBrain Barrier 203. Ingestive Peptides and the Blood¡VBrain Barrier 204. Functional Aspects of Vasoactive Peptides at the Blood¡VBrain Barrier 205. Hypothalamic Neuropeptides and the Blood¡VBrain Barrier 206. Diseases Mediated by the BBB: From Alzheimer¡¦s to Obesity

XX: Other Peptide Topics 207. Prebiotic Peptides 208. Mixture-Based Combinatorial Libraries 209. Use of Synthetic Peptides for Structural and Functional Analyses of Viruses Like HIV 210. Pheromone Peptides 211. Fish Peptides 212. Peptides and Sleep 213. Peptide Chronomics



No. of pages:
© Academic Press 2006
29th August 2006
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

Abba Kastin

Affiliations and Expertise

Pennington Biomedical Research Center, Baton Rouge, LA, USA

Abba Kastin

Abba J. Kastin was born in Ohio and educated at Harvard College and Medical School. After starting his work on neuropeptides at NIH, he went to Louisiana where he now holds an endowed chair at the Pennington Biomedical Research Center. Dr. Kastin has been made an honorary member of 7 foreign medical societies, has received 2 honorary doctorates (1 American and 1 foreign), and has won several national and internaitonal awards. Author of more than 800 papers (25,000 citations), he has been listed among the 100 researchers most cited in the scientific literature.

Affiliations and Expertise

Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

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