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Handbook of Biologically Active Peptides - 1st Edition - ISBN: 9780123694423, 9780080463797

Handbook of Biologically Active Peptides

1st Edition

Editors: Abba Kastin Abba Kastin
Hardcover ISBN: 9780123694423
eBook ISBN: 9780080463797
Imprint: Academic Press
Published Date: 29th August 2006
Page Count: 1640
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Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine.

The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.

Key Features

Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.
Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.


Peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists

Table of Contents


I: Plant Peptides Section
1. 4-kDa Peptide
2. AtPep1 Peptides
3. CLAVATA3: A Putative Peptide Ligand Controlling Arabidopsis StemCell
4. DVL Peptides Are Involved in Plant Development
5. The POLARIS Peptide
6. Phytosulfokine
7. RALF Peptides
8. ROTUNDIFOLIA4: A Plant-Specifi c Small Peptide
9. The S-Locus Cysteine-Rich Peptide SCR/SP11
10. Systemins

II: Bacterial/Antibiotic Peptides Section
11. Cationic Antimicrobial Peptides¡XThe Defensins
12. Cathelicidins: Cationic Host Defense and Antimicrobial Peptides
13. Microcins
14. Peptaibols
15. Nonribosomally Synthesized Microbial Macrocyclic Peptides
16. Lantibiotics
17. The Nonlantibiotic Heat-Stable Bacteriocins in Gram-Positive Bacteria
18. Colicins: Bacterial/Antibiotic Peptides

III: Fungal/Antifungal Peptides Section
19. Fungal Peptides with Antifungal Activity
20. Toxins from Basidiomycete Fungi (Mushroom): Amatoxins, Phallotoxins, and Virotoxins
21. Fungal Peptides with Ribonuclease Activity
22. Fungal Ribosome Inactivating Proteins
23. Peptides and Depsipeptides from Plant Pathogenic Fungi

IV: Invertebrate Peptides Section
24. Insect Diuretic and Antidiuretic Hormones
25. Developmental Peptides: ETH, Corazonin, and PTTH
26. Tachykinins and Tachykinin-Related Peptides in Invertebrates
27. Proctolin in Insects
28. Sulfakinins
29. The Invertebrate AKH/RPCH Family
30. Insect Myosuppressins/FMRFamides and FL/IRFamides/NPFs
31. Allatostatins in the Insects
32. The FXPRLamide (Pyrokinin/PBAN) Peptide Family
33. Insect Pigment Dispersing Factor and Bursicon
34. Crustacean Bioactive Peptides
35. Crustacean Chromatophorotrophins and Hyperglycemic Hormone Peptide Families
36. Molluscan Bioactive Peptides
37. Molluscan Peptides and Reproduction
38. Free-Living Nematode Peptides
39. Parasitic Nematode Peptides

V: Amphibian Peptides Section
40. Amphibian Tachykinins
41. Opioid Peptides from Frog Skin and Bv8-Related Peptides
42. Amphibian Bombesin-Like Peptides
43. Host Defense Peptides from Australian Amphibians: Caerulein and Other Neuropeptides
44. Bradykinin-Related Peptides from Frog Skin
45. The Dermaseptins
46. The Temporins
47. Chromogranins/Secretogranins and Derived Peptides: Insights from the Amphibian Model
48. Sodefrin and Related Pheromones
49. Amphibian Neurohypophysial Peptides
50. Bombinins

VI: Venom Peptides Section
51. Scorpion Venom Peptides
52. Snake Venom Peptides
53. Sea Anemone Venom Peptides
54. Spider Venom Peptides
55. Conus Snail Venom Peptides
56. Insect Venom Peptides
57. Worm Venom Peptides
58. Targets and Therapeutic Properties of Venom Peptides
59. Structure-Function Strategies to Improve the Pharmacological Value of Animal Toxins

VII: Cancer/Anticancer Peptides Section
60. Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Cancer
61. Bombesin-Related Peptides and Neurotensin: Effects on Cancer Growth/Proliferation and Cellular Signaling in Cancer
62. Somatostatin and NPY
63. Bradykinin and Cancer
64. Endothelin
65. Adrenomedullin: An Esoteric Juggernaut of Human Cancers
66. Angiotensin Peptides and Cancer
67. Gastrin and Cancer
68. VIP and PACAP as Autocrine Growth Factors in Breast and Lung Cancer
69. Oxytocin and Cancer
70. Antagonists of Growth Hormone¡VReleasing Hormone (GHRH) in Cancer

VIII: Vaccine Peptides Section
71. Cancer Immunotherapy with Rationally Designed Synthetic Peptides
72. Peptide Vaccines for Cancer Treatment
73. Antiadhesin Synthetic Peptide Consensus Sequence Vaccine and Antibody Therapeutic for Pseudomonas Aeruginosa
74. Peptide Vaccines for Malaria
75. Peptide Vaccine for Otitis Media
76. Peptide Vaccine for Alzheimer¡¦s Disease
77. Peptide Dendrimers as Immunogens

IX: Immunological and Infl ammatory Peptides Section
78. Chemotactic Peptide Ligands for Formylpeptide Receptors Influencing Inflammation
79. Complement-Derived Inflammatory Peptides: Anaphylatoxins
80. Chemokines: A New Peptide Family of Neuromodulators
81. Immune Peptides Related to Dipeptidyl Aminopeptidase IV/CD26
82. RGD-Peptides and Some Immunological Problems
83. Neuropeptides That Regulate Immune Responses
84. Peptides as Targets of T Cell-Mediated Immune Responses
85. The Use of Positional Scanning Synthetic Peptide Combinatorial Libraries to Identify Immunological Relevant Peptides
86. Copolymer 1 and Related Peptides as Immunomodulating Agents
87. CLIP¡XA Multifunctional MHC Class II¡VAssociated Self-Peptide

X: Brain Peptides Section
88. Vasopressin and Oxytocin
89. Thyrotrophin-Releasing Hormone: New Functions for an Ancient Peptide
90. Gonadotrophin Releasing Hormone
91. Brain Somatostatin-Related Peptides
92. Corticotrophin-Releasing Hormone (CRH) Peptide Family
93. Growth Hormone-Releasing Hormone
95. Neuropeptide Y
96. Melanocortins
97. Cocaine- and Amphetamine-Regulated Transcript (CART)
98. The Melanin-Concentrating Hormone
99. CCK/Gastrin
100. The Hypocretins (Orexins)
101. Ghrelin
102. Neurotensin
103. Neuromedin U (NMU): Brain Peptide
104. Galanin and GALP Systems in Brain¡XMolecular Pharmacology, Anatomy, and Putative Roles in Physiology and Pathology
105. Brain Tachykinins
106. CGRP and Adrenomedullin in the Brain
107. The RFamide-Related Peptides
108. Apelin: Discovery, Distribution, and Physiological Role
109. Urotensin II and Urotensin II¡VRelated Peptide
110. Brain/B-Type Natriuretic Peptide (BNP) and C-Type Natriuretic Peptide (CNP)
111. Endozepines
112. KiSS-1/Metastin

XI: Endocrine Peptides Section
113. Role of Opioid Peptides in the Local Regulation of Endocrine Glands
114. Role of Tachykinin-Gene-Related Peptides in the Local Regulation of Endocrine Glands
115. Neuropeptide Y and the Regulation of Endocrine Function
116. Effects of PACAP in the Local Regulation of Endocrine Glands
117. Endothelins in the Local Regulation of Endocrine Glands
118. Adrenomedullin and Related Peptides in the Local Regulation of Endocrine Glands
119. Ghrelin in the Local Regulation of Endocrine Glands
120. Atrial Natriuretic Peptide in Local Regulation of Endocrine Glands
121. Galanin, Neurotensin, and Neuromedins in the Local Regulation of Endocrine Glands

XII: Ingestive Peptides Section
122. Neuropeptide Y: A Conductor of the Appetite-Regulating Orchestra in the Hypothalamus
123. Hypothalamic Galanin and Ingestive Behavior: Relation to Dietary Fat, Alcohol, and Circulating Lipids
124. Effects of Melanocortins on Ingestive Behavior
125. CART Peptide and Ingestive Behavior
126. Orexins and Opioids in Feeding Behavior
127. Melanin-Concentrating Hormone
128. Corticotrophin-Releasing Hormone (CRH) and Ingestive Behavior
129. Peptide YY (PYY) and Neuromedin U (NMU): Effects on Ingestive Behavior
130. Ghrelin and Ingestive Behavior
131. Cholecystokinin and Satiety
132. Enterostatin, a Peptide Regulator of Dietary Fat Ingestion
133. Regulation of Feeding Behavior by Glucagonlike Peptide 1 (GLP-1)
134. Role of Amylin and Calcitonin-Gene-Related Peptide (CGRP) in the Control of Food Intake
135. Leptin and the Regulation of Feeding
136. Ingestive Peptides: Insulin

XIII: Gastrointestinal Peptides Section
137. Adrenomedullin in Gastrointestinal Function
138. Calcitonin Gene-Related Peptide and Gastrointestinal Function
139. Peripheral Cholecystokinin
140. Corticotrophin-Releasing Hormone (CRH) Family in the Gastrointestinal System
141. Paneth Cell „´-Defensins
142. Galanin in the Gastrointestinal Tract: Distribution and Function
143. Gastrin
144. Gastrin-Releasing Peptide
145. Glucagonlike Peptides 1 and 2, Enteroglucagon, Glicentin, and Oxyntomodulin
146. Ghrelin
147. Leptin and the Gastrointestinal Tract
148. Motilin
149. Neurotensin in Regulation of Gastrointestinal Functions
150. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP)
151. Pancreatic Polypeptide
152. Peptide YY
153. Secretin
154. Somatostatin
155. Somatostatin Analogs in the Gastrointestinal Tract
156. Substance P and Related Tachykinins in the Gastrointestinal Tract
157. TFF (Trefoil Factor Family) Peptides
158. Signaling by Vasoactive Intestinal Peptide in Gastrointestinal Smooth Muscle

XIV: Cardiovascular Peptides Section
159. Adrenomedullin and Its Related Peptides
160. Angiotensin II and Its Related Peptides
161. Bradykinin and Its Related Peptides
162. Calcitonin Gene-Related Peptides
163. Endothelins
164. Ghrelin: Its Therapeutic Potential in Heart Failure
165. Natriuretic Peptides in the Cardiovascular System
166. Urotensin and Its Related Peptides
167. Vasoactive Intestinal Peptide
168. Cardiovascular Peptides: Vasopressin

XV: Renal Peptides Section
169. Renal Effects of Neurohypophyseal Peptides
170. Renal Renin-Angiotensin System
171. Renal Natriuretic Peptide System and Actions of Urodilatin
172. ANP and Its Role in the Regulation of Renal Tubular Transport Processes
173. Adrenomedullin as a Renal Peptide
174. Adrenomedullin 2/Intermedin
175. Renal Endothelin
176. Prolactin and Kidney Function

XVI: Respiratory Peptides Section
177. Therapeutic Potential of Adrenomedullin for Pulmonary Hypertension
178. Endothelin in the Airways
179. PACAP¡¦s Role in Pulmonary Function
180. Tachykinins and Their Receptors in the Lung
181. Vasoactive Intestinal Peptide

XVII: Opioid Peptides Section
182. Proenkephalin-Derived Opioid Peptides
183. Prodynorphin-Derived Opioid Peptides
184. POMC Opioid Peptides
185. Endomorphins as Endogenous Peptides for „f-Opioid Receptor: Their Differences in the Pharmacological and Physiological Characters
186. Casomorphins and Hemorphins¡XOpioid Active Peptides Released by Partial Hydrolysis of Structural Proteins
187. Anti-Opioid Peptides
188. Nociceptin
189. Role of Tachykinins in Spinal Nociceptive Mechanisms and Their Interactions with Opioids
190. Exorphin-Opioid Active Peptides of Exogenous Origin
191. Opioid-Substance P Chimeric Peptides

XVIII: Neurotrophic Peptides Section
192. VIP- and PACAP-Related Neuroprotection
193. Insulin-Like Growth Factor 1
194. Erythropoietin¡XA Hematopoietic Hormone with Emerging Diverse Activities
195. Neuregulins
196. The Neurotrophins

XIX: Blood-Brain Barrier Peptides Section
197. Amino Acid Transport Across the Blood¡VBrain Barrier
198. Oligopeptide Transport at the Blood¡VBrain and Blood¡VCSF Barriers
199. Opiate Peptides and the Blood¡VBrain Barrier
200. Permeability of the Blood¡VBrain Barrier to Neurotrophic Peptides
201. Transport of Basic Peptides at the Blood¡VBrain Barrier
202. Fibroblast Growth Factor and the Blood¡VBrain Barrier
203. Ingestive Peptides and the Blood¡VBrain Barrier
204. Functional Aspects of Vasoactive Peptides at the Blood¡VBrain Barrier
205. Hypothalamic Neuropeptides and the Blood¡VBrain Barrier
206. Diseases Mediated by the BBB: From Alzheimer¡¦s to Obesity

XX: Other Peptide Topics
207. Prebiotic Peptides
208. Mixture-Based Combinatorial Libraries
209. Use of Synthetic Peptides for Structural and Functional Analyses of Viruses Like HIV
210. Pheromone Peptides
211. Fish Peptides
212. Peptides and Sleep
213. Peptide Chronomics



No. of pages:
© Academic Press 2006
29th August 2006
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

Abba Kastin

Affiliations and Expertise

Pennington Biomedical Research Center, Baton Rouge, LA, USA

Abba Kastin

Abba J. Kastin was born in Ohio and educated at Harvard College and Medical School. After starting his work on neuropeptides at NIH, he went to Louisiana where he now holds an endowed chair at the Pennington Biomedical Research Center. Dr. Kastin has been made an honorary member of 7 foreign medical societies, has received 2 honorary doctorates (1 American and 1 foreign), and has won several national and internaitonal awards. Author of more than 800 papers (25,000 citations), he has been listed among the 100 researchers most cited in the scientific literature.

Affiliations and Expertise

Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

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