Handbook of Biologically Active Peptides

Handbook of Biologically Active Peptides

1st Edition - August 29, 2006

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  • Editors: Abba Kastin, Abba Kastin
  • eBook ISBN: 9780080463797

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Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.

Key Features

*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.
*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.


Peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists

Table of Contents

  • Contributors

    I: Plant Peptides Section
    1. 4-kDa Peptide
    2. AtPep1 Peptides
    3. CLAVATA3: A Putative Peptide Ligand Controlling Arabidopsis StemCell
    4. DVL Peptides Are Involved in Plant Development
    5. The POLARIS Peptide
    6. Phytosulfokine
    7. RALF Peptides
    8. ROTUNDIFOLIA4: A Plant-Specifi c Small Peptide
    9. The S-Locus Cysteine-Rich Peptide SCR/SP11
    10. Systemins

    II: Bacterial/Antibiotic Peptides Section
    11. Cationic Antimicrobial Peptides¡XThe Defensins
    12. Cathelicidins: Cationic Host Defense and Antimicrobial Peptides
    13. Microcins
    14. Peptaibols
    15. Nonribosomally Synthesized Microbial Macrocyclic Peptides
    16. Lantibiotics
    17. The Nonlantibiotic Heat-Stable Bacteriocins in Gram-Positive Bacteria
    18. Colicins: Bacterial/Antibiotic Peptides

    III: Fungal/Antifungal Peptides Section
    19. Fungal Peptides with Antifungal Activity
    20. Toxins from Basidiomycete Fungi (Mushroom): Amatoxins, Phallotoxins, and Virotoxins
    21. Fungal Peptides with Ribonuclease Activity
    22. Fungal Ribosome Inactivating Proteins
    23. Peptides and Depsipeptides from Plant Pathogenic Fungi

    IV: Invertebrate Peptides Section
    24. Insect Diuretic and Antidiuretic Hormones
    25. Developmental Peptides: ETH, Corazonin, and PTTH
    26. Tachykinins and Tachykinin-Related Peptides in Invertebrates
    27. Proctolin in Insects
    28. Sulfakinins
    29. The Invertebrate AKH/RPCH Family
    30. Insect Myosuppressins/FMRFamides and FL/IRFamides/NPFs
    31. Allatostatins in the Insects
    32. The FXPRLamide (Pyrokinin/PBAN) Peptide Family
    33. Insect Pigment Dispersing Factor and Bursicon
    34. Crustacean Bioactive Peptides
    35. Crustacean Chromatophorotrophins and Hyperglycemic Hormone Peptide Families
    36. Molluscan Bioactive Peptides
    37. Molluscan Peptides and Reproduction
    38. Free-Living Nematode Peptides
    39. Parasitic Nematode Peptides

    V: Amphibian Peptides Section
    40. Amphibian Tachykinins
    41. Opioid Peptides from Frog Skin and Bv8-Related Peptides
    42. Amphibian Bombesin-Like Peptides
    43. Host Defense Peptides from Australian Amphibians: Caerulein and Other Neuropeptides
    44. Bradykinin-Related Peptides from Frog Skin
    45. The Dermaseptins
    46. The Temporins
    47. Chromogranins/Secretogranins and Derived Peptides: Insights from the Amphibian Model
    48. Sodefrin and Related Pheromones
    49. Amphibian Neurohypophysial Peptides
    50. Bombinins

    VI: Venom Peptides Section
    51. Scorpion Venom Peptides
    52. Snake Venom Peptides
    53. Sea Anemone Venom Peptides
    54. Spider Venom Peptides
    55. Conus Snail Venom Peptides
    56. Insect Venom Peptides
    57. Worm Venom Peptides
    58. Targets and Therapeutic Properties of Venom Peptides
    59. Structure-Function Strategies to Improve the Pharmacological Value of Animal Toxins

    VII: Cancer/Anticancer Peptides Section
    60. Analogs of Luteinizing Hormone-Releasing Hormone (LHRH) in Cancer
    61. Bombesin-Related Peptides and Neurotensin: Effects on Cancer Growth/Proliferation and Cellular Signaling in Cancer
    62. Somatostatin and NPY
    63. Bradykinin and Cancer
    64. Endothelin
    65. Adrenomedullin: An Esoteric Juggernaut of Human Cancers
    66. Angiotensin Peptides and Cancer
    67. Gastrin and Cancer
    68. VIP and PACAP as Autocrine Growth Factors in Breast and Lung Cancer
    69. Oxytocin and Cancer
    70. Antagonists of Growth Hormone¡VReleasing Hormone (GHRH) in Cancer

    VIII: Vaccine Peptides Section
    71. Cancer Immunotherapy with Rationally Designed Synthetic Peptides
    72. Peptide Vaccines for Cancer Treatment
    73. Antiadhesin Synthetic Peptide Consensus Sequence Vaccine and Antibody Therapeutic for Pseudomonas Aeruginosa
    74. Peptide Vaccines for Malaria
    75. Peptide Vaccine for Otitis Media
    76. Peptide Vaccine for Alzheimer¡¦s Disease
    77. Peptide Dendrimers as Immunogens

    IX: Immunological and Infl ammatory Peptides Section
    78. Chemotactic Peptide Ligands for Formylpeptide Receptors Influencing Inflammation
    79. Complement-Derived Inflammatory Peptides: Anaphylatoxins
    80. Chemokines: A New Peptide Family of Neuromodulators
    81. Immune Peptides Related to Dipeptidyl Aminopeptidase IV/CD26
    82. RGD-Peptides and Some Immunological Problems
    83. Neuropeptides That Regulate Immune Responses
    84. Peptides as Targets of T Cell-Mediated Immune Responses
    85. The Use of Positional Scanning Synthetic Peptide Combinatorial Libraries to Identify Immunological Relevant Peptides
    86. Copolymer 1 and Related Peptides as Immunomodulating Agents
    87. CLIP¡XA Multifunctional MHC Class II¡VAssociated Self-Peptide

    X: Brain Peptides Section
    88. Vasopressin and Oxytocin
    89. Thyrotrophin-Releasing Hormone: New Functions for an Ancient Peptide
    90. Gonadotrophin Releasing Hormone
    91. Brain Somatostatin-Related Peptides
    92. Corticotrophin-Releasing Hormone (CRH) Peptide Family
    93. Growth Hormone-Releasing Hormone
    94. PACAP/VIP
    95. Neuropeptide Y
    96. Melanocortins
    97. Cocaine- and Amphetamine-Regulated Transcript (CART)
    98. The Melanin-Concentrating Hormone
    99. CCK/Gastrin
    100. The Hypocretins (Orexins)
    101. Ghrelin
    102. Neurotensin
    103. Neuromedin U (NMU): Brain Peptide
    104. Galanin and GALP Systems in Brain¡XMolecular Pharmacology, Anatomy, and Putative Roles in Physiology and Pathology
    105. Brain Tachykinins
    106. CGRP and Adrenomedullin in the Brain
    107. The RFamide-Related Peptides
    108. Apelin: Discovery, Distribution, and Physiological Role
    109. Urotensin II and Urotensin II¡VRelated Peptide
    110. Brain/B-Type Natriuretic Peptide (BNP) and C-Type Natriuretic Peptide (CNP)
    111. Endozepines
    112. KiSS-1/Metastin

    XI: Endocrine Peptides Section
    113. Role of Opioid Peptides in the Local Regulation of Endocrine Glands
    114. Role of Tachykinin-Gene-Related Peptides in the Local Regulation of Endocrine Glands
    115. Neuropeptide Y and the Regulation of Endocrine Function
    116. Effects of PACAP in the Local Regulation of Endocrine Glands
    117. Endothelins in the Local Regulation of Endocrine Glands
    118. Adrenomedullin and Related Peptides in the Local Regulation of Endocrine Glands
    119. Ghrelin in the Local Regulation of Endocrine Glands
    120. Atrial Natriuretic Peptide in Local Regulation of Endocrine Glands
    121. Galanin, Neurotensin, and Neuromedins in the Local Regulation of Endocrine Glands

    XII: Ingestive Peptides Section
    122. Neuropeptide Y: A Conductor of the Appetite-Regulating Orchestra in the Hypothalamus
    123. Hypothalamic Galanin and Ingestive Behavior: Relation to Dietary Fat, Alcohol, and Circulating Lipids
    124. Effects of Melanocortins on Ingestive Behavior
    125. CART Peptide and Ingestive Behavior
    126. Orexins and Opioids in Feeding Behavior
    127. Melanin-Concentrating Hormone
    128. Corticotrophin-Releasing Hormone (CRH) and Ingestive Behavior
    129. Peptide YY (PYY) and Neuromedin U (NMU): Effects on Ingestive Behavior
    130. Ghrelin and Ingestive Behavior
    131. Cholecystokinin and Satiety
    132. Enterostatin, a Peptide Regulator of Dietary Fat Ingestion
    133. Regulation of Feeding Behavior by Glucagonlike Peptide 1 (GLP-1)
    134. Role of Amylin and Calcitonin-Gene-Related Peptide (CGRP) in the Control of Food Intake
    135. Leptin and the Regulation of Feeding
    136. Ingestive Peptides: Insulin

    XIII: Gastrointestinal Peptides Section
    137. Adrenomedullin in Gastrointestinal Function
    138. Calcitonin Gene-Related Peptide and Gastrointestinal Function
    139. Peripheral Cholecystokinin
    140. Corticotrophin-Releasing Hormone (CRH) Family in the Gastrointestinal System
    141. Paneth Cell „´-Defensins
    142. Galanin in the Gastrointestinal Tract: Distribution and Function
    143. Gastrin
    144. Gastrin-Releasing Peptide
    145. Glucagonlike Peptides 1 and 2, Enteroglucagon, Glicentin, and Oxyntomodulin
    146. Ghrelin
    147. Leptin and the Gastrointestinal Tract
    148. Motilin
    149. Neurotensin in Regulation of Gastrointestinal Functions
    150. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP)
    151. Pancreatic Polypeptide
    152. Peptide YY
    153. Secretin
    154. Somatostatin
    155. Somatostatin Analogs in the Gastrointestinal Tract
    156. Substance P and Related Tachykinins in the Gastrointestinal Tract
    157. TFF (Trefoil Factor Family) Peptides
    158. Signaling by Vasoactive Intestinal Peptide in Gastrointestinal Smooth Muscle

    XIV: Cardiovascular Peptides Section
    159. Adrenomedullin and Its Related Peptides
    160. Angiotensin II and Its Related Peptides
    161. Bradykinin and Its Related Peptides
    162. Calcitonin Gene-Related Peptides
    163. Endothelins
    164. Ghrelin: Its Therapeutic Potential in Heart Failure
    165. Natriuretic Peptides in the Cardiovascular System
    166. Urotensin and Its Related Peptides
    167. Vasoactive Intestinal Peptide
    168. Cardiovascular Peptides: Vasopressin

    XV: Renal Peptides Section
    169. Renal Effects of Neurohypophyseal Peptides
    170. Renal Renin-Angiotensin System
    171. Renal Natriuretic Peptide System and Actions of Urodilatin
    172. ANP and Its Role in the Regulation of Renal Tubular Transport Processes
    173. Adrenomedullin as a Renal Peptide
    174. Adrenomedullin 2/Intermedin
    175. Renal Endothelin
    176. Prolactin and Kidney Function

    XVI: Respiratory Peptides Section
    177. Therapeutic Potential of Adrenomedullin for Pulmonary Hypertension
    178. Endothelin in the Airways
    179. PACAP¡¦s Role in Pulmonary Function
    180. Tachykinins and Their Receptors in the Lung
    181. Vasoactive Intestinal Peptide

    XVII: Opioid Peptides Section
    182. Proenkephalin-Derived Opioid Peptides
    183. Prodynorphin-Derived Opioid Peptides
    184. POMC Opioid Peptides
    185. Endomorphins as Endogenous Peptides for „f-Opioid Receptor: Their Differences in the Pharmacological and Physiological Characters
    186. Casomorphins and Hemorphins¡XOpioid Active Peptides Released by Partial Hydrolysis of Structural Proteins
    187. Anti-Opioid Peptides
    188. Nociceptin
    189. Role of Tachykinins in Spinal Nociceptive Mechanisms and Their Interactions with Opioids
    190. Exorphin-Opioid Active Peptides of Exogenous Origin
    191. Opioid-Substance P Chimeric Peptides

    XVIII: Neurotrophic Peptides Section
    192. VIP- and PACAP-Related Neuroprotection
    193. Insulin-Like Growth Factor 1
    194. Erythropoietin¡XA Hematopoietic Hormone with Emerging Diverse Activities
    195. Neuregulins
    196. The Neurotrophins

    XIX: Blood-Brain Barrier Peptides Section
    197. Amino Acid Transport Across the Blood¡VBrain Barrier
    198. Oligopeptide Transport at the Blood¡VBrain and Blood¡VCSF Barriers
    199. Opiate Peptides and the Blood¡VBrain Barrier
    200. Permeability of the Blood¡VBrain Barrier to Neurotrophic Peptides
    201. Transport of Basic Peptides at the Blood¡VBrain Barrier
    202. Fibroblast Growth Factor and the Blood¡VBrain Barrier
    203. Ingestive Peptides and the Blood¡VBrain Barrier
    204. Functional Aspects of Vasoactive Peptides at the Blood¡VBrain Barrier
    205. Hypothalamic Neuropeptides and the Blood¡VBrain Barrier
    206. Diseases Mediated by the BBB: From Alzheimer¡¦s to Obesity

    XX: Other Peptide Topics
    207. Prebiotic Peptides
    208. Mixture-Based Combinatorial Libraries
    209. Use of Synthetic Peptides for Structural and Functional Analyses of Viruses Like HIV
    210. Pheromone Peptides
    211. Fish Peptides
    212. Peptides and Sleep
    213. Peptide Chronomics


Product details

  • No. of pages: 1640
  • Language: English
  • Copyright: © Academic Press 2006
  • Published: August 29, 2006
  • Imprint: Academic Press
  • eBook ISBN: 9780080463797

About the Editors

Abba Kastin

Affiliations and Expertise

Pennington Biomedical Research Center, Baton Rouge, LA, USA

Abba Kastin

Abba J. Kastin was born in Ohio and educated at Harvard College and Medical School. After starting his work on neuropeptides at NIH, he went to Louisiana where he now holds an endowed chair at the Pennington Biomedical Research Center. Dr. Kastin has been made an honorary member of 7 foreign medical societies, has received 2 honorary doctorates (1 American and 1 foreign), and has won several national and internaitonal awards. Author of more than 800 papers (25,000 citations), he has been listed among the 100 researchers most cited in the scientific literature.

Affiliations and Expertise

Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

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