Handbook of Basal Ganglia Structure and Function

Handbook of Basal Ganglia Structure and Function

2nd Edition - September 15, 2016

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  • Editors: Heinz Steiner, Kuei Tseng
  • Hardcover ISBN: 9780128022061
  • eBook ISBN: 9780128025260

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Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated overview of the structural and functional aspects of the basal ganglia, highlighting clinical relevance. The basal ganglia, a group of forebrain nuclei interconnected with the cerebral cortex, thalamus, and brainstem, are involved in numerous brain functions, such as motor control and learning, sensorimotor integration, reward, and cognition. These nuclei are essential for normal brain function and behavior, and their importance is further emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. This updated edition has been thoroughly revised to provide the most up-to-date account of this critical brain structure. Edited and authored by internationally acclaimed basal ganglia researchers, the new edition contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, detailed accounts of recent advances in cellular/molecular mechanisms and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction.

Key Features

  • Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cellular/molecular and cellular/physiological mechanisms, and behavioral and clinical aspects of function and dysfunction
  • Written by international authors who are preeminent researchers in the field
  • Explores, in full, the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases


Neuroscience researchers in need of an overview of recent advances regarding the basal ganglia, neuroscience clinicians seeking information on the pathophysiology and associated diseases, and neuroscience graduate students looking for basic information on structure and function

Table of Contents

  • Part A: The Basal Ganglia System and its Evolution
    1. History of the Basal Ganglia
    2. Anatomical Organization of the Basal Ganglia
    3. Evolution of the Vertebrate Basal Ganglia
    4. Cell Types in the Basal Ganglia 

    Part B: Anatomy and Physiology of the Striatum
    5. Striatal Medium Spiny Projection Neurons and their Connections
    6. Cholinergic Interneurons of the Striatum
    7. GABAergic Interneurons of the Striatum
    8. Dopamine Signaling in Striatal Medium Spiny Neurons
    9. Endocannabinoid Signaling in the Striatum
    10. Nitric Oxide Signaling in the Striatum
    11. Adenosine Signaling in the Basal Ganglia 

    Part C: Anatomy and Physiology of Globus Pallidus, Subthalamic Nucleus and Substantia Nigra
    12. The Globus Pallidus
    13. The Subthalamic Nucleus
    14. The Substantia Nigra Pars Reticulata
    15. Subtypes of Midbrain Dopamine Neurons
    16. Neurophysiology of Substantia Nigra Dopamine Neurons
    17. Plasticity in Dopamine Neurons
    18. Regulation of Extracellular Dopamine: Release and Reuptake 

    Part D: Network Integration
    19. Organization of Corticostriatal Projection Neuron Types
    20. Organization of Prefrontal-Striatal Connections
    21. Gating of Cortical Input to the Striatum
    22. Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions
    23. Organization of the Thalamostriatal Systems
    24. The Rostromedial Tegmental Nucleus: Connections to the Basal Ganglia
    25. The Rostromedial Tegmental Nucleus: A Modulator of Dopamine Systems
    26. Integrative Networks Across Basal Ganglia Circuits 

    Part E: Molecular Signaling in the Basal Ganglia
    27. Second-Messenger Cascades
    28. DARPP32/Phosphatase Signaling
    29. Transsynaptic Regulation of Basal Ganglia Gene Expression
    30. Psychostimulant-Induced Gene Regulation in Corticostriatal Circuits
    31. Epigenetics in Neuropathologies of the Basal Ganglia

    Part F: Basal Ganglia Function and Dysfunction
    32. Investigating Basal Ganglia Function with Cell-Type-Specific Manipulations
    33. Basal Ganglia Re-Entrant Loops: Roles in Action Selection and Reinforcement
    34. Memory Systems in the Basal Ganglia
    35. Basal Ganglia Dynamics During Action Sequence (Motor) Learning
    36. Abnormal Activities in Cortico-Basal Ganglia Circuits in Movement Disorders
    37. Morphological Plasticity in the Striatum Associated with Dopamine Dysfunction
    38. Neuroinflammation in Movement Disorders
    39. Basal Ganglia Disorders Related to Striosome/Matrix Compartments
    40. Drug Addiction: the Neural and Psychological Basis of a Compulsive Incentive Habit
    41. Parkinson’s Disease: Cross-Talk Between Environmental Factors and Gene Defects
    42. Parkinson’s Disease: Molecular Determinants of Vulnerability in Dopamine Neurons
    43. Parkinson’s Disease: Genetics
    44. Molecular Mechanisms of L-DOPA-Induced Dyskinesia
    45. Cell Therapy in Parkinson’s Disease: An Update
    46. Huntington’s Disease: Molecular Basis
    47. Huntington’s Disease: Insights from Animal Models
    48. Dystonia
    49. Tourette Syndrome
    50. Deep-Brain Stimulation for Neurologic and Psychiatric Disorders

Product details

  • No. of pages: 1036
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: September 15, 2016
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128022061
  • eBook ISBN: 9780128025260

About the Editors

Heinz Steiner

Heinz Steiner is Professor and Chair of the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Steiner is an expert on the functional organization of the basal ganglia and related brain systems. His research focuses, in particular, on the role of the neurotransmitter dopamine in the regulation of basal ganglia–cortical interactions; his recent investigations examine how chronic enhancement of dopamine actions produce changes in gene regulation, and how these molecular alterations affect basal ganglia function and behavior. He has been the North America Regional Editor for the journal Basal Ganglia since 2011.

Affiliations and Expertise

Dept. of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, USA

Kuei Tseng

Kuei Y. Tseng is Associate Professor in the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Tseng’s research focuses on the neural bases of Parkinson’s disease, particularly the effects of dopamine loss within the cortico–basal ganglia circuitry and the mechanisms underlying information processing in the brains of individuals affected by Parkinson’s disease. He is the editor of two books on the cortex.

Affiliations and Expertise

Dept. of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, USA

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  • John H. Tue May 15 2018

    Handbook of Basal Ganglia Structure and Function

    Excellent reviews on an ever more complicated subject.