Handbook of Basal Ganglia Structure and Function - 2nd Edition - ISBN: 9780128022061, 9780128025260

Handbook of Basal Ganglia Structure and Function, Volume 24

2nd Edition

eBook ISBN: 9780128025260
Hardcover ISBN: 9780128022061
Imprint: Academic Press
Published Date: 26th September 2016
Page Count: 1036
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Table of Contents

Part A: The Basal Ganglia System and its Evolution
1. History of the Basal Ganglia
2. Anatomical Organization of the Basal Ganglia
3. Evolution of the Vertebrate Basal Ganglia
4. Cell Types in the Basal Ganglia 

Part B: Anatomy and Physiology of the Striatum
5. Striatal Medium Spiny Projection Neurons and their Connections
6. Cholinergic Interneurons of the Striatum
7. GABAergic Interneurons of the Striatum
8. Dopamine Signaling in Striatal Medium Spiny Neurons
9. Endocannabinoid Signaling in the Striatum
10. Nitric Oxide Signaling in the Striatum
11. Adenosine Signaling in the Basal Ganglia 

Part C: Anatomy and Physiology of Globus Pallidus, Subthalamic Nucleus and Substantia Nigra
12. The Globus Pallidus
13. The Subthalamic Nucleus
14. The Substantia Nigra Pars Reticulata
15. Subtypes of Midbrain Dopamine Neurons
16. Neurophysiology of Substantia Nigra Dopamine Neurons
17. Plasticity in Dopamine Neurons
18. Regulation of Extracellular Dopamine: Release and Reuptake 

Part D: Network Integration
19. Organization of Corticostriatal Projection Neuron Types
20. Organization of Prefrontal-Striatal Connections
21. Gating of Cortical Input to the Striatum
22. Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions
23. Organization of the Thalamostriatal Systems
24. The Rostromedial Tegmental Nucleus: Connections to the Basal Ganglia
25. The Rostromedial Tegmental Nucleus: A Modulator of Dopamine Systems
26. Integrative Networks Across Basal Ganglia Circuits 

Part E: Molecular Signaling in the Basal Ganglia
27. Second-Messenger Cascades
28. DARPP32/Phosphatase Signaling
29. Transsynaptic Regulation of Basal Ganglia Gene Expression
30. Psychostimulant-Induced Gene Regulation in Corticostriatal Circuits
31. Epigenetics in Neuropathologies of the Basal Ganglia

Part F: Basal Ganglia Fun


Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated overview of the structural and functional aspects of the basal ganglia, highlighting clinical relevance. The basal ganglia, a group of forebrain nuclei interconnected with the cerebral cortex, thalamus, and brainstem, are involved in numerous brain functions, such as motor control and learning, sensorimotor integration, reward, and cognition.

These nuclei are essential for normal brain function and behavior, and their importance is further emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction.

This updated edition has been thoroughly revised to provide the most up-to-date account of this critical brain structure. Edited and authored by internationally acclaimed basal ganglia researchers, the new edition contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, detailed accounts of recent advances in cellular/molecular mechanisms and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction.

Key Features

  • Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cellular/molecular and cellular/physiological mechanisms, and behavioral and clinical aspects of function and dysfunction
  • Written by international authors who are preeminent researchers in the field
  • Explores, in full, the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases


Neuroscience researchers in need of an overview of recent advances regarding the basal ganglia, neuroscience clinicians seeking information on the pathophysiology and associated diseases, and neuroscience graduate students looking for basic information on structure and function


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