Handbook of Basal Ganglia Structure and Function

Handbook of Basal Ganglia Structure and Function

1st Edition - February 1, 2010

Write a review

  • Editors: Heinz Steiner, Kuei Tseng
  • eBook ISBN: 9780080912158

Purchase options

Purchase options
DRM-free (EPub, Mobi, PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the basal ganglia, with special emphasis on the progress achieved over the last 10-15 years. Organized in six parts, the volume describes the general anatomical organization and provides a review of the evolution of the basal ganglia, followed by detailed accounts of recent advances in anatomy, cellular/molecular, and cellular/physiological mechanisms, and our understanding of the behavioral and clinical aspects of basal ganglia function and dysfunction.

Key Features

  • Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cell-molecular and cell-physiological mechanisms, and behavioral/clinical aspects of function and dysfunction
  • Features a truly international cast of the preeminent researchers in the field
  • Fully explores the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases


Libraries of institutions with Neuroscience programs; Neuroscience research specialists looking for an overview of recent advances; Neuroscience clinicians interested in the pathophysiology and associated diseases; Neuroscience graduate students looking for basic information on structure and function.

Table of Contents

  • Part A: The Basal Ganglia System and its Evolution
    Chapter 1. The Neuroanatomical Organization of the Basal Ganglia
    Charles R. Gerfen
    Chapter 2. The Conservative Evolution of the Vertebrate Basal Ganglia
    A. Reiner
    Chapter 3. Cell Types in the Different Nuclei of the Basal Ganglia
    Dorothy E. Oorschot
    Chapter 4. Neurotransmitter Receptors in the Basal Ganglia
    Piers C. Emson, Henry Waldvogel and Richard Faull
    Part B: Anatomy and Physiology of the Striatum
    Chapter 5. The Striatal Skeleton: Medium Spiny Projection Neurons and their Lateral Connections
    Dietmar Plenz and Jeffery R. Wickens
    Chapter 6. D1 and D2 Dopamine Receptor Modulation of Striatal Glutamatergic Signaling in Striatal Medium Spiny Neurons
    D. James Surmeier, Michelle Day, Tracy Gertler, Savio Chan and Weixing Shen
    Chapter 7. The Cholinergic Interneurons of the Striatum: Intrinsic Properties Underlie Multiple Discharge Patterns
    Joshua A. Goldberg and Charles J. Wilson
    Chapter 8. GABAergic Interneurons of the Neostriatum
    James M. Tepper
    Chapter 9. Endocannabinoid Signaling in the Striatum
    David M. Lovinger, Margaret I. Davis and Rui M. Costa
    Chapter 10. Nitric Oxide Signaling in the Striatum
    Anthony R. West
    Chapter 11. Adenosine-Dopamine Receptor Interaction
    Micaela Morelli, Simola Nicola, Popoli Patrizia and Carta Anna R.
    Chapter 12. Regulation of Corticostriatal Synaptic Plasticity in Physiological and Pathological Conditions
    Massimiliano Di Filippo and Paolo Calabresi
    Part C: Anatomy and Physiology of Globus Pallidus, Subthalamic Nucleus and Substantia Nigra
    Chapter 13. Organization of the Globus Pallidus
    Hitoshi Kita
    Chapter 14. Projections from Pallidum to Striatum
    Pieter Voorn
    Chapter 15. The Subthalamic Nucleus: From in vitro to in vivo Mechanisms
    Stephane Charpier, Corinne Beurrier and Jeanne T. Paz
    Chapter 16. Neurophysiology of Substantia Nigra Dopaminergic Neurons: Modulation by GABAergic Afferents
    James M. Tepper
    Chapter 17. Regulation of Extracellular Dopamine: Release and Reuptake
    David Sulzer, Hui Zhang, Marianne Benoit-Marand, and Francois Gonon
    Part D: Network Integration
    Chapter 18. Organization of Corticostriatal Projection Neuron Types
    Anton Reiner
    Chapter 19. Gating of Cortical Input to the Striatum
    Jeffery R. Wickens and Gordon W. Arbuthnott
    Chapter 20. Organization of Prefrontal-Striatal Connections
    Henk J. Groenewegen and Harry B.M. Uylings
    Chapter 21. Gating of Limbic Input to the Ventral Striatum
    Patricio O’Donnell
    Chapter 22. Anatomical and Functional Organization of the Thalamostriatal Systems
    Yoland Smith, Adriana Galvan, Dinesh Raju and Thomas Wichmann
    Chapter 23. Subcortical Connections of the Basal Ganglia
    David I.G. Wilson, Philip Winn and Peter Redgrave
    Chapter 24. Integrative Networks across Basal Ganglia Circuits
    Suzanne N. Haber
    Chapter 25. Synchronous Activity in Basal Ganglia-Cortical Circuits
    J.R. Walters and D.A. Bergstrom
    Part E: Molecular Signaling in the Basal Ganglia
    Chapter 26. Second Messenger Cascades
    Stephanie E. Bronson and Christine Konradi
    Chapter 27. Neurotransmitter Regulation of Basal Ganglia Gene Expression
    Kristen A. Keefe and Kristen A. Horner
    Chapter 28. D1-Dopamine Receptor Supersensitivity in the Striatum
    Charles R. Gerfen
    Chapter 29. Psychostimulant-Induced Gene Regulation in Cortico-Striatal Circuits
    Heinz Steiner
    Chapter 30. Chromatin Remodeling: Role in Neuropathologies of the Basal Ganglia
    Jocelyne Caboche, Emmanuel Roze, Karen Brami-Cherrier and Sandrine Betuing
    Part F: Basal Ganglia Function and Dysfunction
    Chapter 31. Phasic Dopamine Signaling and Basal Ganglia Function
    Peter Redgrave, Veronique Coizet and John Reynolds
    Chapter 32. Basal Ganglia-Mediated Motor Learning
    M.G. Packard
    Chapter 33. Drug Addiction: The Neural and Psychological Basis of a Compulsive Incentive Habit
    David Belin and Barry J. Everitt
    Chapter 34. Environmental Contributions to Parkinson’s disease: Cross Talk between Environmental Factors and Gene Defects
    Gloria E. Meredith and Susan Totterdell
    Chapter 35. Alterations in Corticostriatal Synaptic Function in Huntington’s and Parkinson’s Diseases
    Carlos Cepeda, Nigel S. Bamford, Véronique M. André and Michael S. Levine
    Chapter 36. Molecular Mechanisms of L-DOPA-Induced Dyskinesia
    M. Angela Cenci
    Chapter 37. Compensatory Mechanisms in Experimental and Human Parkinsonism: Potential for New Therapies
    Erwan Bezard, Grégory Porras, Javier Blesa and José A. Obeso
    Chapter 38. Pathological Synchrony of Basal Ganglia-Cortical Networks in the Systemic MPTP Primate Model of Parkinson's Disease
    Hagai Bergman, Adam Zaidel, Boris Rosin, Maya Slovik, Michal Rivlin-Etzion, Shay Moshel and Zvi Israel
    Chapter 39. Deep-Brain Stimulation for Neurologic and Psychiatric Disorders
    Mahlon R. DeLong and Thomas Wichmann

Product details

  • No. of pages: 704
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: February 1, 2010
  • Imprint: Academic Press
  • eBook ISBN: 9780080912158

About the Editors

Heinz Steiner

Heinz Steiner is Professor and Chair of the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Steiner is an expert on the functional organization of the basal ganglia and related brain systems. His research focuses, in particular, on the role of the neurotransmitter dopamine in the regulation of basal ganglia–cortical interactions; his recent investigations examine how chronic enhancement of dopamine actions produce changes in gene regulation, and how these molecular alterations affect basal ganglia function and behavior. He has been the North America Regional Editor for the journal Basal Ganglia since 2011.

Affiliations and Expertise

Dept. of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, USA

Kuei Tseng

Kuei Y. Tseng is Associate Professor in the Department of Cellular and Molecular Pharmacology at the Chicago Medical School/Rosalind Franklin University of Medicine and Science in Chicago, Illinois. Dr. Tseng’s research focuses on the neural bases of Parkinson’s disease, particularly the effects of dopamine loss within the cortico–basal ganglia circuitry and the mechanisms underlying information processing in the brains of individuals affected by Parkinson’s disease. He is the editor of two books on the cortex.

Affiliations and Expertise

Dept. of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, USA

Ratings and Reviews

Write a review

Latest reviews

(Total rating for all reviews)

  • abbas s. Thu Dec 28 2017

    Handbook of Basal Ganglia

    Some chapters related to physiology are excellent. Others related to anatomy can be repetitive and rehash similar previous reviews. Overall a good reference work for the advanced reader.