Handbook of Anxiety and Fear

Handbook of Anxiety and Fear

1st Edition - March 17, 2008

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  • Editors: Robert Blanchard, Guy Griebel, David Nutt
  • Hardcover ISBN: 9780444530653
  • eBook ISBN: 9780080559520

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This Handbook brings together and integrates comprehensively the core approaches to fear and anxiety. Its four sections: Animal models; neural systems; pharmacology; and clinical approaches, provide a range of perspectives that interact to produce new light on these important and sometimes dysfunctional emotions. Fear and anxiety are analyzed as patterns that have evolved on the basis of their adaptive functioning in response to threat. These patterns are stringently selected, providing a close fit with environmental situations and events; they are highly conservative across mammalian species, producing important similarities, along with some systematic differences, in their human expression in comparison to that of nonhuman mammals. These patterns are described, with attention to both adaptive and maladaptive components, and related to new understanding of neuroanatomic, neurotransmitter, and genetic mechanisms. Although chapters in the volume acknowledge important differences in views of fear and anxiety stemming from animal vs. human research, the emphasis of the volume is on a search for an integrated view that will facilitate the use of animal models of anxiety to predict drug response in people; on new technologies that will enable direct evaluation of biological mechanisms in anxiety disorders; and on strengthening the analysis of anxiety disorders as biological phenomena.

Key Features

• Integrates animal and human research on fear and anxiety
• Presents emerging and developing fields of human anxiety research including imaging of anxiety disorders, the genetics of anxiety, the pharmacology of anxiolysis, recent developments in classification of anxiety disorders, linking these to animal work
• Covers basic research on innate and conditioned responses to threat
• Presents work from the major laboratories, on fear learning and extinction
• Reviews research on an array of neurotransmitter and neuromodulator systems related to fear and anxiety
• Compares models, and neural systems for learned versus unlearned responses to threat
• Relates the findings to the study, diagnostics, and treatment of anxiety disorders, the major source of mental illness in modern society (26 % of Americans are affected by anxiety disorders!)


Neuroscientists, Psychologists, Psychopharmacologists, Clinical Psychologists and Psychiatrists

Table of Contents

  • Section 1. Introduction

    Introduction to the Handbook on Fear and Anxiety
    Robert Blanchard, D. Caroline Blanchard, Guy Griebel and David Nutt

    Section 2. Animal models of Anxiety, Fear and Defense

    Theoretical approaches to the modeling of anxiety in animals
    Neil McNaughton and Hélio Zangrossi Jr.,

    The use of conditioning tasks to model fear and anxiety
    Michael S. Fanselow and Ravikumar Ponnusamy

    Extinction of fear: from animal studies to clinical interventions
    Karyn M. Myers and Michael Davis

    Defensive behaviors, fear and anxiety
    D. Caroline Blanchard and Robert Blanchard

    Unconditioned models of fear and anxiety
    Yoav Litvin, Nathan S. Pentkowski, Roger L. Pobbe, D. Caroline Blanchard and Robert J. Blanchard

    Section 3. Neural Systems for Anxiety, Fear, and Defense

    Brain mechanisms of Pavlovian and instrumental aversive conditioning
    Christopher K. Cain and Joseph E. LeDoux

    Neural systems activated in response to predators and partial predator stimuli
    Newton Sabino Canteras

    A behavioral and neural systems comparison of unconditioned and conditioned defensive behavior
    Newton S. Canteras and D. Caroline Blanchard

    Section 4. The Pharmacology of Anxiety, Fear, and Defense

    Peptide receptor ligands to treat anxiety disorders
    Thomas Steckler

    Subtype-selective GABAA/benzodiazepine receptor ligands for the treatment of anxiety disorders
    James K. Rowlett

    Modulation of anxiety behaviors by 5-HT-interacting drugs
    Francisco Silveira Guimarães, Antonio Pádua Carobrez and Frederico Guilherme Graeff

    The glutamatergic system as a potential therapeutic target for the treatment of anxiety disorders
    John F. Cryan and Kumlesh K. Dev

    The endocannabinoid system and anxiety responses
    Marco Bortolato and Daniele Piomelli

    Genetic factors underlying anxiety-behaviour: a meta-analysis of rodent studies involving targeted mutations of neurotransmission genes
    Catherine Belzung, Samuel Leman and Guy Griebel

    The pharmacology of anxiolysis
    Andrew Holmes

    Section 5. Handbook of Fear and Anxiety:

    Clinical and Experimental Considerations
    Phenomenology of anxiety disorders
    David J. Nutt, Berta Garcia de Miguel and Simon J.C. Davies

    How effective are current drug treatments for anxiety disorders, and how could they be improved?
    David S. Baldwin and Matthew J. Garner

    Experimental models: panic and fear
    Gabriel Esquivel, Koen Schruers and Eric Griez

    Principles and findings from human imaging of anxiety disorders
    Andrea L. Malizia and David Nutt

    Stress hormones and anxiety disorders
    Elizabeth A. Young, James L. Abelson and Israel Liberzon

    The genetics of human anxiety disorders
    Eduard Maron, John M. Hettema and Jakov Shlik

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Elsevier Science 2008
  • Published: March 17, 2008
  • Imprint: Elsevier Science
  • Hardcover ISBN: 9780444530653
  • eBook ISBN: 9780080559520

About the Editors

Robert Blanchard

Guy Griebel

David Nutt

Affiliations and Expertise

Edmond J Safra Chair in Neuropsychopharmacology, Imperial College London, UK

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