Handbook of Advanced Chromatography /Mass Spectrometry Techniques

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

1st Edition - September 7, 2017

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  • Editors: Michal Holcapek, Wm. Craig Byrdwell
  • eBook ISBN: 9780128117330
  • Paperback ISBN: 9780128117323

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Handbook of Advanced Chromatography /Mass Spectrometry Techniques is a compendium of new and advanced analytical techniques that have been developed in recent years for analysis of all types of molecules in a variety of complex matrices, from foods to fuel to pharmaceuticals and more. Focusing on areas that are becoming widely used or growing rapidly, this is a comprehensive volume that describes both theoretical and practical aspects of advanced methods for analysis. Written by authors who have published the foundational works in the field, the chapters have an emphasis on lipids, but reach a broader audience by including advanced analytical techniques applied to a variety of fields. Handbook of Advanced Chromatography / Mass Spectrometry Techniques is the ideal reference for those just entering the analytical fields covered, but also for those experienced analysts who want a combination of an overview of the techniques plus specific and pragmatic details not often covered in journal reports. The authors provide, in one source, a synthesis of knowledge that is scattered across a multitude of literature articles. The combination of pragmatic hints and tips with theoretical concepts and demonstrated applications provides both breadth and depth to produce a valuable and enduring reference manual. It is well suited for advanced analytical instrumentation students as well as for analysts seeking additional knowledge or a deeper understanding of familiar techniques.

Key Features

  • Includes UHPLC, HILIC, nano-liquid chromatographic separations, two-dimensional LC-MS (LCxLC), multiple parallel MS, 2D-GC (GCxGC) methodologies for lipids analysis, and more
  • Contains both practical and theoretical knowledge, providing core understanding for implementing modern chromatographic and mass spectrometric techniques
  • Presents chapters on the most popular and fastest-growing new techniques being implemented in diverse areas of research


Upper level undergraduate students and graduate students, researchers, technicians, and scientists

Table of Contents

  • 1. The Theory and Practice of UHPLC and UHPLC-MS
    2. Advances in Hydrophilic Interaction Liquid Chromatography
    3. Chiral Separations. Chiral Dynamic Chromatography in the Study of Stereolabile Compounds
    4. Silver-ion Liquid Chromatography - Mass Spectrometry
    5. Porous Monolithic Layers and Mass Spectrometry
    6. New Materials for Stationary Phases in Liquid Chromatography/Mass Spectrometry
    7. Introduction to Two-Dimensional Liquid Chromatography – Theory and Practice
    8. Recent Advances in Comprehensive Two-Dimensional Liquid Chromatography for the Analysis of Natural Products
    9. Nano-Liquid Chromatographic Separations
    10. Multiple Parallel Mass Spectrometry for Liquid Chromatography
    11. Comprehensive Gas Chromatography Methodologies for the Analysis of Lipids  
    12. Ultra-High Performance Supercritical Fluid Chromatography – Mass Spectrometry

Product details

  • No. of pages: 520
  • Language: English
  • Copyright: © Academic Press and AOCS Press 2017
  • Published: September 7, 2017
  • Imprint: Academic Press and AOCS Press
  • eBook ISBN: 9780128117330
  • Paperback ISBN: 9780128117323

About the Editors

Michal Holcapek

Professor of analytical chemistry and head of mass spectrometry group at the Department of Analytical Chemistry, University of Pardubice. His research started with the structural analysis of organic and organometallic compounds using mass spectrometry (MS) and its coupling with liquid chromatography, focused mainly on the metabolism of pharmaceutical and natural compounds. His present specialization is the lipidomic analysis of biological samples using liquid chromatography and supercritical fluid chromatography coupled to MS, shotgun MS, MALDI-MS and MS imaging. He has coauthored over 110 papers in peer-reviewed journals with h-index of 33 and given over 300 conference presentations including over 20 plenary and keynote lectures. He is a member of editorial board of Analytical and Bioanalytical Chemistry; Lipids; a guest editor of special volumes on Mass spectrometry in Journal of Chromatography A (2010, 2012 and 2016), Lipidomics in Analytical Chemistry (2014) and Analytical and Bioanalytical Chemistry (2015), editor of the book Extreme Chromatography: Faster, Hotter, Smaller (American Oil Chemical Society, 2011), and on Power List of 100 most influential people in the analytical sciences (The Analytical Scientist, 2013 and 2015).

Affiliations and Expertise

Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic

Wm. Craig Byrdwell

Research Chemist with the United States Department of Agriculture, ARS.Currently Dr. Byrdwell is working on analysis of vitamin D and other fat soluble vitamins and triacylglycerols using triple- and quadruple- parallel mass spectrometry approaches, combining the best aspects of three or four mass spectrometers employing complementary ionization methods in LCx/MSy techniques.

Affiliations and Expertise

Food Composition and Methods Development Lab, USDA, ARS, Beltsville Human Nutrition Research Center, Beltsville, Maryland, USA

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