Growth Factors

Growth Factors

1st Edition - December 20, 1984

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  • Editor: Choh Hao Li
  • eBook ISBN: 9780323162548

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Hormonal Proteins and Peptides: Growth Factors, Volume XII focuses on the chemistry and biology of nerve growth factor (NGF), insulin-like growth factors/somatomedins/multiplication-stimulating activity (IGFs/SMs/MSA), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), and skeletal growth factor (SGF). This book discusses the development of growth factors in cell proliferation, differentiation, and malignancy. Organized into eight chapters, this volume starts with an overview of the findings on the structural and biological properties of NGF. This text then discusses the identical amino acid sequences of IFG-I and SM-c and explains as well the similarities in the structure of IFG-II and MSA. Other chapters present a thorough discussion of human PDGF, with emphasis on the link between the PDGF and the simian sarcoma virus gene product. This book discusses as well the mechanism of action of the pituitary and brain FGF. The final chapter deals with the discovery, isolation, and characterization of the biological activities of epidermal growth factor (EGF). This book is a valuable resource for biochemists, endocrinologists, and physicians.

Table of Contents

  • Contributors


    Contents of Previous Volumes

    1 The Nerve Growth Factor (NGF)

    I. Introduction and Brief Survey of Early Findings

    II. Large and Small Biological Sources of NGFs

    III. Chemical and Structural Properties of NGF

    IV. Hormonal Control of NGF Synthesis

    V. Biological Effects of Endogenous Salivary Gland NGF

    VI. Biological Effects of NGF in Living Organisms and In Vitro Experimental Systems

    VII. The Mechanism of Action of NGF

    VIII. Temporal Dissection of NGF Effects in PC 12 Cells

    IX. Concluding Remarks and Perspectives


    2 Insulin-like Growth Factors, Somatomedins, and Multiplication Stimulating Activity: Chemistry

    I. Introduction

    II. Purification

    III. Amino Acid Sequence

    IV. Models of the Three-Dimensional Structure

    V. Chemical Synthesis

    VI. Concluding Remarks


    3 The Somatomedins: Biological Actions and Physiologic Control Mechanisms

    I. Introduction

    II. Methods of Detection and Quantitation

    III. In Vitro Biological Effects of the Somatomedins

    IV. In Vivo Effects

    V. Relationship between Growth Hormone and Somatomedin

    VI. Physiologic Regulation of Serum Somatomedin Concentrations

    VII. Conclusion


    4 Insulin-like Growth Factors: Biosynthesis, Receptors, and Carrier Proteins

    I. Introduction

    II. Biosynthesis of Insulin-like Growth Factors

    III. IGF Receptors

    IV. IGF Carrier Proteins

    V. Conclusions


    5 Brain and Pituitary Fibroblast Growth Factors

    I. Introduction

    II. Purification and Characterization of Pituitary and Brain Fibroblast Growth Factors

    III. Effect of Pituitary and Brain FGF on Cultured Cells

    IV. Mechanism of FGF Action

    V. The Extracellular Matrix and the Control of Cell Proliferation

    VI. Plasma Factors Involved in the Proliferation of Normal Diploid Cells

    VII. In Vivo Effect of FGF

    VIII. Conclusion


    6 Human Platelet-Derived Growth Factor

    I. Introduction

    II. Studies Leading to the Recognition of PDGF

    III. Purification and Characterization of PDGF

    IV. Amino Acid Sequence and Structural Identity between PDGF and the Simian Sarcoma Virus Transforming Protein

    V. PDGF and Malignant Transformation

    VI. Physiologic Functions of PDGF

    VII. Platelet-Derived Mitogens for Tumor Cells

    VIII. Production of PDGF-like Polypeptides by Human Malignant Cells in Culture

    IX. Possible In Vivo Functions of PDGF


    7 Skeletal Growth Factor

    I. Introduction

    II. Historical Perspective

    III. Purification of Skeletal Growth Factors

    IV. Properties of Skeletal Growth Factors

    V. Function of Skeletal Growth Factor

    VI. Unanswered Questions


    8 Epidermal Growth Factor (EGF): Historical Perspectives

    I. Introduction

    II. Characterization

    III. Determination of Mode of Action

    IV. Research Applications



Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 1984
  • Published: December 20, 1984
  • Imprint: Academic Press
  • eBook ISBN: 9780323162548

About the Editor

Choh Hao Li

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