Growth Factors

1st Edition - December 20, 1984
Editor: Choh Hao Li
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 6 2 5 4 - 8

Hormonal Proteins and Peptides: Growth Factors, Volume XII focuses on the chemistry and biology of nerve growth factor (NGF), insulin-like growth… Read more

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Hormonal Proteins and Peptides: Growth Factors, Volume XII focuses on the chemistry and biology of nerve growth factor (NGF), insulin-like growth factors/somatomedins/multiplication-stimulating activity (IGFs/SMs/MSA), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), and skeletal growth factor (SGF). This book discusses the development of growth factors in cell proliferation, differentiation, and malignancy. Organized into eight chapters, this volume starts with an overview of the findings on the structural and biological properties of NGF. This text then discusses the identical amino acid sequences of IFG-I and SM-c and explains as well the similarities in the structure of IFG-II and MSA. Other chapters present a thorough discussion of human PDGF, with emphasis on the link between the PDGF and the simian sarcoma virus gene product. This book discusses as well the mechanism of action of the pituitary and brain FGF. The final chapter deals with the discovery, isolation, and characterization of the biological activities of epidermal growth factor (EGF). This book is a valuable resource for biochemists, endocrinologists, and physicians.

Contributors

Preface

Contents of Previous Volumes

1 The Nerve Growth Factor (NGF)

I. Introduction and Brief Survey of Early Findings

II. Large and Small Biological Sources of NGFs

III. Chemical and Structural Properties of NGF

IV. Hormonal Control of NGF Synthesis

V. Biological Effects of Endogenous Salivary Gland NGF

VI. Biological Effects of NGF in Living Organisms and In Vitro Experimental Systems

VII. The Mechanism of Action of NGF

VIII. Temporal Dissection of NGF Effects in PC 12 Cells

IX. Concluding Remarks and Perspectives

References

2 Insulin-like Growth Factors, Somatomedins, and Multiplication Stimulating Activity: Chemistry

I. Introduction

II. Purification

III. Amino Acid Sequence

IV. Models of the Three-Dimensional Structure

V. Chemical Synthesis

VI. Concluding Remarks

References

3 The Somatomedins: Biological Actions and Physiologic Control Mechanisms

I. Introduction

II. Methods of Detection and Quantitation

III. In Vitro Biological Effects of the Somatomedins

IV. In Vivo Effects

V. Relationship between Growth Hormone and Somatomedin

VI. Physiologic Regulation of Serum Somatomedin Concentrations

VII. Conclusion

References

4 Insulin-like Growth Factors: Biosynthesis, Receptors, and Carrier Proteins

I. Introduction

II. Biosynthesis of Insulin-like Growth Factors

III. IGF Receptors

IV. IGF Carrier Proteins

V. Conclusions

References

5 Brain and Pituitary Fibroblast Growth Factors

I. Introduction

II. Purification and Characterization of Pituitary and Brain Fibroblast Growth Factors

III. Effect of Pituitary and Brain FGF on Cultured Cells

IV. Mechanism of FGF Action

V. The Extracellular Matrix and the Control of Cell Proliferation

VI. Plasma Factors Involved in the Proliferation of Normal Diploid Cells

VII. In Vivo Effect of FGF

VIII. Conclusion

References

6 Human Platelet-Derived Growth Factor

I. Introduction

II. Studies Leading to the Recognition of PDGF

III. Purification and Characterization of PDGF

IV. Amino Acid Sequence and Structural Identity between PDGF and the Simian Sarcoma Virus Transforming Protein

V. PDGF and Malignant Transformation

VI. Physiologic Functions of PDGF

VII. Platelet-Derived Mitogens for Tumor Cells

VIII. Production of PDGF-like Polypeptides by Human Malignant Cells in Culture

IX. Possible In Vivo Functions of PDGF

References

7 Skeletal Growth Factor

I. Introduction

II. Historical Perspective

III. Purification of Skeletal Growth Factors

IV. Properties of Skeletal Growth Factors

V. Function of Skeletal Growth Factor

VI. Unanswered Questions

References

8 Epidermal Growth Factor (EGF): Historical Perspectives

I. Introduction

II. Characterization

III. Determination of Mode of Action

IV. Research Applications

References

Index