Growth Factors in Development - 1st Edition - ISBN: 9780123859754, 9780123859761

Growth Factors in Development, Volume 97

1st Edition

Serial Volume Editors: Carman Birchmeier
eBook ISBN: 9780123859761
Hardcover ISBN: 9780123859754
Imprint: Academic Press
Published Date: 17th November 2011
Page Count: 264
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Table of Contents

Series Page



Chapter one: New Insights into Signaling During Myelination in Zebrafish

1. Introduction

2. Schwann Cell Development

Forward Genetic Screens

Reverse Genetics: Morpholinos, TILLING, and Zinc Fingers

Small Molecules

In vivo imaging

3. Neuregulin1/ErbB Signaling

4. Gpr126

5. New Roles for Schwann Cells

6. Oligodendrocytes

7. Conclusions and Future Directions

Chapter two: Wnt Signaling

1. Overview of Wnt Signal Transduction Cascades

2. Wnt Proteins: Different Branches of Signaling

3. Regulation of Wnt Signaling Above the Receptor Level

4. Regulation of Wnt Signaling Pathways at the Receptor Level

5. Conclusions and Perspective

Chapter three: Notch-Independent Functions of CSL

1. Introduction

2. CSL as a Repressor

3. CSL as a Notch-Independent Transcriptional Activator

4. Role of cis-Regulatory Modules in Determining Target Gene Transcription

5. Role of Competition Between CSL-Containing Complexes—Is CSL a Limiting Factor?

6. Concluding Remarks

Chapter four: Sonic Hedgehog Signaling in the Developing CNS

1. Prologue: Identification of Shh

2. Setting the Stage: Shh Signaling During Nervous System Regionalization

3. I Am Dying to Hear from You: The Range of Shh Signaling in the CNS

4. Character Creation: Production and Secretion of Shh Protein

5. Won't You Take My Hand: Shh-Binding Proteins and Diffusion

6. Character Development: Transduction of Shh Signal in Receiving Cells

7. Cutting in on the Dance: The Interplay Between Ptc and Smo

8. Taking It to the Extreme: The Central Role of the Primary Cilium in Shh Signaling

9. Stepping into the Dark: How Does Smo Control Gli Phosphorylation?

10. Are You Going to Use That Thing? Smo as a G-Protein-Coupled Receptor

11. Being in the Right Place at the Right Time: Shh–Gli Signaling and Patterning in the Ventral Neural Tube

12. Walking Down the Runway: A Model for Shh–Gli Control of Early Progenitor Patterning

13. What’s It Gonna Be, Boy? GliA Versus GliR-Regulated Genes

14. New Game: Distinct Mechanisms for GliA-and GliR-Mediated Transcription

15. Summary and Further Questions

Chapter five: Activity-Mediated Synapse Formation

1. Introduction

2. Wnts and Their Receptors

3. The Role of Wnt Signaling in Synapse Formation

4. Role of Neuronal Activity in Wnt-Mediated Dendrite Morphogenesis

5. Role of Neuronal Activity in Wnt-Mediated Synapse Formation

6. Concluding Remarks

Chapter six: Signaling Pathways and Axis Formation in the Lower Metazoa

1. Introduction

2. Animal Relationships and the Origin of the Basal Metazoa

3. Wnt Signaling

4. TGF-β and BMP Signaling

5. Negative Regulators of BMP and Wnt Signaling

6. Axis Formation and Regeneration in Basal Metazoans

7. Conclusions and Outlook

Chapter seven: FGF and ROR2 Receptor Tyrosine Kinase Signaling in Human Skeletal Development

1. Introduction

2. FGF Signaling: Craniosynostosis, Digit Abnormalities, and Short Stature

3. The Atypical Receptor TK ROR2 and WNT Signaling

Subject index

Contents of previous volume


This new volume of the renowned serial Current Topics in Developmental Biology covers the important features of growth factors in development. With an international board of authors, this volume will be invaluable for researchers in cell, developmental and molecular biology.

Key Features

  • Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area
  • This volume provides an up-to-date and timely perspective


Researchers in cell, developmental, and molecular biology; genetics


No. of pages:
© Academic Press 2011
Academic Press
eBook ISBN:
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About the Serial Volume Editors

Carman Birchmeier Serial Volume Editor