Growth Factors in Development

Growth Factors in Development

1st Edition - November 7, 2011

Write a review

  • Editor: Carmen Birchmeier
  • Hardcover ISBN: 9780123859754
  • eBook ISBN: 9780123859761

Purchase options

Purchase options
DRM-free (EPub, PDF, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


This new volume of the renowned serial Current Topics in Developmental Biology covers the important features of growth factors in development. With an international board of authors, this volume will be invaluable for researchers in cell, developmental and molecular biology.

Key Features

  • Provides researchers an overview and synthesis of the latest research findings and contemporary thought in the area
  • This volume provides an up-to-date and timely perspective


Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

  • Series Page



    Chapter one: New Insights into Signaling During Myelination in Zebrafish

    1. Introduction

    2. Schwann Cell Development

    Forward Genetic Screens

    Reverse Genetics: Morpholinos, TILLING, and Zinc Fingers

    Small Molecules

    In vivo imaging

    3. Neuregulin1/ErbB Signaling

    4. Gpr126

    5. New Roles for Schwann Cells

    6. Oligodendrocytes

    7. Conclusions and Future Directions

    Chapter two: Wnt Signaling

    1. Overview of Wnt Signal Transduction Cascades

    2. Wnt Proteins: Different Branches of Signaling

    3. Regulation of Wnt Signaling Above the Receptor Level

    4. Regulation of Wnt Signaling Pathways at the Receptor Level

    5. Conclusions and Perspective

    Chapter three: Notch-Independent Functions of CSL

    1. Introduction

    2. CSL as a Repressor

    3. CSL as a Notch-Independent Transcriptional Activator

    4. Role of cis-Regulatory Modules in Determining Target Gene Transcription

    5. Role of Competition Between CSL-Containing Complexes—Is CSL a Limiting Factor?

    6. Concluding Remarks

    Chapter four: Sonic Hedgehog Signaling in the Developing CNS

    1. Prologue: Identification of Shh

    2. Setting the Stage: Shh Signaling During Nervous System Regionalization

    3. I Am Dying to Hear from You: The Range of Shh Signaling in the CNS

    4. Character Creation: Production and Secretion of Shh Protein

    5. Won't You Take My Hand: Shh-Binding Proteins and Diffusion

    6. Character Development: Transduction of Shh Signal in Receiving Cells

    7. Cutting in on the Dance: The Interplay Between Ptc and Smo

    8. Taking It to the Extreme: The Central Role of the Primary Cilium in Shh Signaling

    9. Stepping into the Dark: How Does Smo Control Gli Phosphorylation?

    10. Are You Going to Use That Thing? Smo as a G-Protein-Coupled Receptor

    11. Being in the Right Place at the Right Time: Shh–Gli Signaling and Patterning in the Ventral Neural Tube

    12. Walking Down the Runway: A Model for Shh–Gli Control of Early Progenitor Patterning

    13. What’s It Gonna Be, Boy? GliA Versus GliR-Regulated Genes

    14. New Game: Distinct Mechanisms for GliA-and GliR-Mediated Transcription

    15. Summary and Further Questions

    Chapter five: Activity-Mediated Synapse Formation

    1. Introduction

    2. Wnts and Their Receptors

    3. The Role of Wnt Signaling in Synapse Formation

    4. Role of Neuronal Activity in Wnt-Mediated Dendrite Morphogenesis

    5. Role of Neuronal Activity in Wnt-Mediated Synapse Formation

    6. Concluding Remarks

    Chapter six: Signaling Pathways and Axis Formation in the Lower Metazoa

    1. Introduction

    2. Animal Relationships and the Origin of the Basal Metazoa

    3. Wnt Signaling

    4. TGF-β and BMP Signaling

    5. Negative Regulators of BMP and Wnt Signaling

    6. Axis Formation and Regeneration in Basal Metazoans

    7. Conclusions and Outlook

    Chapter seven: FGF and ROR2 Receptor Tyrosine Kinase Signaling in Human Skeletal Development

    1. Introduction

    2. FGF Signaling: Craniosynostosis, Digit Abnormalities, and Short Stature

    3. The Atypical Receptor TK ROR2 and WNT Signaling

    Subject index

    Contents of previous volume

Product details

  • No. of pages: 264
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: November 7, 2011
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123859754
  • eBook ISBN: 9780123859761

About the Serial Volume Editor

Carmen Birchmeier

Ratings and Reviews

Write a review

There are currently no reviews for "Growth Factors in Development"