Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science

Biomedical Application of Biosurfactant in Medical Sector

1st Edition - March 22, 2022

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  • Editors: Inamuddin, Charles Adetunji, Mohd Ahamed
  • Paperback ISBN: 9780323851466
  • eBook ISBN: 9780323984171

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Description

Green Sustainable Process for Chemical and Environmental Engineering and Science: Biomedical Application of Biosurfactant in Medical Sector highlights the numerous applications of biosurfactants in the field of medicine, especially as a replacement to synthetic drugs which have developed several levels of resistance over the years. Special emphasis is laid on their application as non-pyrogenic and non-toxic immunological adjuvants and their inhibitory characteristics against H+, K+, -ATPase and defense against gastric ulcers, along with their practical application as anti-adhesive coating agents for medical insert materials. The book addresses issues by combining knowledge of their production with information on a range of medical applications. Drawing on the knowledge of its expert team of global contributors, this book provides useful insights for all those currently or potentially interested in developing or applying biosurfactants in their own work.

Key Features

  • Reflects on differing strains of fungi, bacteria, actinomycetes and yeast, and reviews genetic modification of such strains for enhanced biosurfactant production
  • Explores the use of biosurfactants across a broad range of medical applications
  • Provides mathematical modeling, metabolomics, bioinformatics, metabolic engineering, systems biology and computer technology for solving real-life challenges using biosurfactants
  • Presents biosurfactants as an innovative green, biotechnological solution to improve human health
  • Highlights the numerous applications of biosurfactants in the field of medicine, most especially as a replacement to synthetic drugs which have been reported to develop several levels of resistance over the years

Readership

Graduates, post-graduates and researchers across both academia and industry interested in developing and/or applying biosurfactants including, microbiologists, chemical engineers, green/ analytical/ environmental chemists, sustainability researchers, and environmental scientists, researchers in colloid science, surfactant science, physico-chemists, and materials scientists

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • List of contributors
  • Chapter 1. Application of low molecular weight and high molecular weight biosurfactant in medicine/biomedical/pharmaceutical industries
  • Abstract
  • 1.1 Introduction
  • 1.2 High molecular weight biosurfactant
  • 1.3 Low molecular weight biosurfactant
  • 1.4 Conclusions
  • References
  • Chapter 2. Application of biosurfactant as an adjuvant in medicine
  • Abstract
  • 2.1 Introduction
  • 2.2 Biosurfactant types and structure–activity relationship
  • 2.3 Lipopeptides
  • 2.4 Surfactin and surfactin derived
  • 2.5 Nucleolipids
  • 2.6 Glycolipids
  • 2.7 Full peptides
  • 2.8 Medicinal properties of biosurfactants
  • 2.9 Biosurfactants as antitumor agents
  • 2.10 Biosurfactants as antiviral agents
  • 2.11 Biosurfactants as antibacterial agents
  • 2.12 Biosurfactants as drug-delivery agents
  • 2.13 Biosurfactants as antiadhesive agents
  • 2.14 Biosurfactants as antimicrobial agents
  • 2.15 Biosurfactants: mechanism of interaction
  • 2.16 Conclusion
  • References
  • Chapter 3. Applications of biosurfactants in dentistry
  • Abstract
  • 3.1 Introduction
  • 3.2 Oral biofilm
  • 3.3 Biosurfactants versus synthetic surfactants
  • 3.4 Therapeutic properties of biosurfactants in biomedical field
  • 3.5 Biosurfactants from lactic acid bacteria strains
  • 3.6 Other sources of biosurfactants
  • 3.7 Applications of biosurfactants in oral health
  • 3.8 Biosurfactants and future goals
  • 3.9 Conclusion
  • References
  • Chapter 4. Expansion of targeted drug-delivery systems using microbially sources biosurfactant
  • Abstract
  • 4.1 Introduction
  • 4.2 Microbial biosurfactants
  • 4.3 Microbial biosurfactants as drug-delivery systems
  • 4.4 Types of biosurfactant-based drug-delivery system
  • 4.5 Conclusions and future challenges
  • Acknowledgments
  • References
  • Chapter 5. Inhibition of fibrin clot formation
  • Abstract
  • 5.1 Introduction
  • 5.2 Coagulation factors and fibrin clot formation
  • 5.3 Consequences of fibrin clot formation
  • 5.4 Inhibition of fibrin clot formation
  • 5.5 Biosurfactants as drug
  • 5.6 Conclusion
  • References
  • Chapter 6. Application of biosurfactant for the management of tropical and life-threatening diseases
  • Abstract
  • 6.1 Introduction
  • 6.2 Framework of the research study
  • 6.3 Tropical and life-threatening diseases
  • 6.4 Application of the biosurfactants against tropical and life-threatening diseases
  • 6.5 Conclusion
  • Acknowledgments
  • Conflict of interest
  • References
  • Chapter 7. Application of biosurfactant for the management of Plasmodium parasites
  • Abstract
  • 7.1 Introduction
  • 7.2 Environmental application of biosurfactant for the management of different types of mosquitoes
  • 7.3 Biology of Plasmodium species
  • 7.4 Conclusion and future recommendation
  • References
  • Chapter 8. Role of biosurfactant in the destruction of pores and destabilization of the biological membrane of pathogenic microorganisms
  • Abstract
  • 8.1 Introduction
  • 8.2 Modes of action involved in the biological activity of biosurfactants as antipathogen agent
  • 8.3 Modes of action involved in the biological activity of biosurfactants as larvicidal agents agent
  • 8.4 The mechanism involved in the biological control of pathogenic microorganisms
  • 8.5 Modes of action involved in the application of biosurfactant as an antibacterial agent
  • 8.6 Modes of action involved in the application of biosurfactant as antiyeast and antifungal (pathogenic microorganism of medical relevance)
  • 8.7 Treatment of the parasite using in vivo and in vitro treatments of malaria parasites
  • 8.8 Modes of action involved in the application of biosurfactant for the management of the vector and the parasites
  • 8.9 Conclusion and future recommendation
  • References
  • Further reading
  • Chapter 9. Antibacterial and antifungal activities of lipopeptides
  • Abstract
  • 9.1 Introduction
  • 9.2 Specific examples of antifungal and antibacterial properties of iturins
  • 9.3 Specific examples of lipopeptides as antibacterial and antifungal agents
  • 9.4 The antiparasitic and antitumor activities of surfactin
  • 9.5 Synthesis, extraction, and purification of biosurfactant
  • 9.6 Physicochemical separation parameters of biosurfactants
  • 9.7 Direct liquid partitioning from cell culture
  • 9.8 Separation by precipitation
  • 9.9 Solvent extraction
  • 9.10 Ammonium sulfate precipitation method
  • 9.11 Zinc sulfate precipitation method
  • 9.12 Acid precipitation method
  • 9.13 Studies on extraction and purification of biosurfactants
  • 9.14 Characterization of biosurfactant
  • 9.15 Fourier transform infrared features of glycolipids
  • 9.16 Fengycin
  • 9.17 Isolation and purification of lipopeptides
  • 9.18 Conclusion and future recommendation
  • References
  • Chapter 10. The role of biosurfactants in the advancement of veterinary medicine
  • Abstract
  • 10.1 Introduction
  • 10.2 Properties of biosurfactants
  • 10.3 Types of biosurfactants
  • 10.4 Toxicity of biosurfactant
  • 10.5 Potential application of biosurfactants in veterinary field
  • 10.6 Future prospects and conclusion
  • Acknowledgment
  • Conflicts of interest
  • References
  • Chapter 11. Applications of surfactin and other biosurfactants in anticancer activity
  • Abstract
  • 11.1 Introduction
  • 11.2 Characteristics and mechanism of action of biosurfactants
  • 11.3 Applications of biosurfactants in anticancer activity
  • 11.4 Applications of surfactin in anticancer activity
  • 11.5 Applications of other biosurfactants in cancer therapy
  • 11.6 Conclusion
  • References
  • Chapter 12. Inhibitory activity of biosurfactants against H+-K+ ATPases and defense against gastric ulcers
  • Abstract
  • 12.1 Introduction
  • 12.2 Biosurfactants: potential application as a therapeutic target
  • 12.3 Function of H+/K+-ATPase in gastric ulcer formation
  • 12.4 Efficiency of proton pump inhibitors to treat gastric ulcers
  • 12.5 Pumilacidin: its role in the control of gastric ulcer
  • 12.6 Conclusion
  • References
  • Chapter 13. Applications of biosurfactants as nonpyrogenic and nontoxic immunologic adjuvants
  • Abstract
  • 13.1 Introduction
  • 13.2 Biological and therapeutic role of biosurfactants
  • 13.3 Immunomodulatory role of biosurfactants
  • 13.4 Biosurfactants and immunologic adjuvants
  • 13.5 Applications of biosurfactants as immunologic adjuvants
  • 13.6 General mechanism of immunologic adjuvant activity
  • References
  • Chapter 14. Antifungal activity of biosurfactant against profound mycosis
  • Abstract
  • 14.1 Introduction
  • 14.2 Production of biosurfactants
  • 14.3 Properties characterization of the biosurfactants
  • 14.4 Etiological agents of profound mycoses and application of biosurfactants against them
  • 14.5 Final considerations
  • References
  • Chapter 15. Hemolysis and formation of ion channels in lipid membrane
  • Abstract
  • 15.1 Introduction
  • 15.2 Role of biosurfactants
  • 15.3 Classification of surfactants
  • 15.4 Mechanism of hemolysis caused by surfactants
  • 15.5 Role of lipid layer in pore formation and membrane lysis
  • 15.6 Mechanism of pore formation and membrane lysis
  • 15.7 Applications of biosurfactants
  • 15.8 Structural aspects of biosurfactants playing role in hemolysis and membrane lysis
  • 15.9 Factors influencing pore formation
  • 15.10 Research work on the role of surfactants in hemolysis
  • 15.11 Research on the role of biosurfactants in pore formation and membrane lysis
  • 15.12 Conclusion
  • References
  • Chapter 16. Biosurfactant as a vehicle for targeted antitumor and anticancer drug delivery
  • Abstract
  • 16.1 Introduction
  • 16.2 Properties of biosurfactant
  • 16.3 Antitumor and anticancer properties of biosurfactants
  • 16.4 Biosurfactants as drug carriers
  • 16.5 Conclusion and future outlook
  • References
  • Further reading
  • Chapter 17. Biosurfactants in the pharmaceuticalsciences
  • Abstract
  • 17.1 Introduction
  • 17.2 Main uses of surfactants in the pharmaceutical industry
  • 17.3 Biosurfactants
  • 17.4 Reports of biosurfactants employed in the pharmaceutical sector
  • 17.5 Final considerations
  • References
  • Chapter 18. Naturally occurring bioactive biosurfactants
  • Abstract
  • 18.1 Introduction
  • 18.2 Bioactivity of naturally occurring biosurfactants
  • 18.3 Conclusions
  • Acknowledgement
  • References
  • Chapter 19. Application of biosurfactants in the treatment of Mycobacterium tuberculosis infection
  • Abstract
  • 19.1 Introduction
  • 19.2 Biosurfactants
  • 19.3 Biosurfactant synthesis
  • 19.4 Properties of biosurfactants
  • 19.5 Mycobacterium tuberculosis
  • 19.6 Molecular mechanism of Mycobacterium tuberculosis
  • 19.7 Therapeutics of Mycobacterium tuberculosis
  • 19.8 Future prospective
  • References
  • Chapter 20. Biosurfactants role in nanotechnology for anticancer treatment
  • Abstract
  • 20.1 Introduction
  • 20.2 Types of biosurfactants
  • 20.3 Biosurfactants as surface modifiers
  • 20.4 Role of biosurfactants in cancer therapy
  • 20.5 Future perspective
  • References
  • Chapter 21. Application of low- and high-molecular-weight biosurfactants in medicine/biomedical/pharmaceutical industries
  • Abstract
  • 21.1 Introduction
  • 21.2 Classification of biosurfactants
  • 21.3 Applications of biosurfactant
  • 21.4 Conclusion
  • References
  • Chapter 22. Biosurfactants for pharmacological interventions in cancer therapy
  • Abstract
  • 22.1 Introduction
  • 22.2 Types and sources of biosurfactants
  • 22.3 Raw materials used for biosurfactant production
  • 22.4 Biosurfactant with potent anticancer activity against different cancers with mechanism
  • 22.5 Biosurfactant-nanoconjugates for cancer treatment
  • 22.6 Biosurfactant-nanoconjugates in diagnosis
  • 22.7 Biosurfactant-nanoconjugates in treatment
  • 22.8 Conclusion and future perspectives
  • Acknowledgment
  • References
  • Chapter 23. Biosurfactants in respiratory viruses and the Coronavirus disease 2019 pandemic
  • Abstract
  • 23.1 Introduction
  • 23.2 A quick overview of biosurfactants
  • 23.3 Viruses and biosurfactants
  • 23.4 Conclusion
  • Acknowledgement
  • References
  • Chapter 24. Biosurfactant as an intervention for medical device associated infections
  • Abstract
  • 24.1 Introduction
  • 24.2 Nosocomial device-associated infections
  • 24.3 Role of biofilms on device-associated infections
  • 24.4 Role of biosurfactants in biofilm mode of growth
  • 24.5 Application of biosurfactant specific to device-associated infections
  • 24.6 Conclusion
  • Acknowledgment
  • References
  • Chapter 25. Biosurfactants for industrial applications
  • Abstract
  • 25.1 Introduction
  • 25.2 Materials and methods for biosurfactants
  • 25.3 Industrial applications of biosurfactant in biomedical area
  • 25.4 Conclusion and future perspectives
  • References
  • Chapter 26. Antitumor and anticancer activity of biosurfactant
  • Abstract
  • 26.1 Introduction
  • 26.2 Anticancer and antitumor activity of biosurfactants
  • 26.3 Other biomedical applications
  • 26.4 Conclusion
  • References
  • Chapter 27. Biosurfactant as antibiofilm agent
  • Abstract
  • 27.1 Introduction
  • 27.2 What is biofilm?
  • 27.3 Biosurfactants
  • 27.4 Biosurfactants as antibiofilm agent
  • 27.5 Conclusion
  • References
  • Chapter 28. Rheological behavior of biosurfactants
  • Abstract
  • 28.1 Introduction
  • 28.2 Brief introduction on biosurfactants
  • 28.3 Rheological properties of some biosurfactants and their systems
  • 28.4 Conclusions
  • References
  • Chapter 29. Biosurfactants for optimal delivery of poorly soluble therapeutic agents
  • Abstract
  • 29.1 Introduction
  • 29.2 Biosurfactants: important component in pharmaceutical products
  • 29.3 Potential advantages of biosurfactants
  • 29.4 Classification of biosurfactants
  • 29.5 Biosurfactants for delivery of poorly soluble drugs
  • 29.6 Concluding remarks
  • References
  • Chapter 30. Role of surfactants in pulmonary drug delivery
  • Abstract
  • 30.1 Introduction
  • 30.2 Pulmonary diseases management: therapies and interventions
  • 30.3 Surfactants: properties and applications
  • 30.4 Biosurfactants: source, properties, and purpose
  • 30.5 Applications of biosurfactants in pulmonary diseases
  • 30.6 Clinical trial perspective
  • 30.7 Conclusion
  • References
  • Chapter 31. Antioxidant activity of biogenic surfactants
  • Abstract
  • 31.1 Biosurfactants
  • 31.2 Properties of biosurfactants
  • 31.3 Classification and chemical nature of biosurfactants
  • 31.4 Biosurfactant production
  • 31.5 Characterization of biosurfactants
  • 31.6 Applications of biosurfactants
  • 31.7 Antioxidants
  • 31.8 Methods for evaluation of antioxidant activity
  • 31.9 Biosurfactants and their antioxidant property
  • 31.10 Conclusion
  • References
  • Chapter 32. Recent advances in biosurfactant as antiadhesion/antibiofilm agents
  • Abstract
  • 32.1 Introduction
  • 32.2 Microbial biofilm formation
  • 32.3 Biosurfactant as antiadhesive agent
  • 32.4 Biosurfactant as antibiofilm agent
  • 32.5 Conclusion and future prospects
  • References
  • Chapter 33. Current trends in the application of biosurfactant in the synthesis of nanobiosurfactant such as engineered biomolecules from various biosurfactant derived from diverse sources, nanoparticles, and nanorobots
  • Abstract
  • 33.1 Introduction
  • 33.2 Microbial synthesis of biosurfactants
  • 33.3 Conclusion
  • References
  • Chapter 34. Application of biosurfactants in the food industry: supply chain and green economy perspectives
  • Abstract
  • 34.1 Introduction
  • 34.2 Methodology
  • 34.3 Biosurfactant production from food and agro-waste
  • 34.4 Potential food applications of biosurfactants
  • 34.5 Discussion and analysis
  • 34.6 Conclusion
  • Acknowledgment
  • References
  • Chapter 35. Understanding mechanisms underlying genes regulating the production of biosurfactant
  • Abstract
  • 35.1 Introduction
  • 35.2 Mechanism of working of biosurfactants
  • 35.3 Enhancing the surface area of water-insoluble hydrophobic substances
  • 35.4 Increasing biological availability of water-insoluble substances
  • 35.5 Molecular genetic mechanisms of microbial synthesis of biosurfactants
  • 35.6 Gene regulation in fungal biosurfactants
  • 35.7 Molecular engineering facets for novel and customized biosurfactants
  • 35.8 Commercial applications of biosurfactants
  • 35.9 Toxicological and ecological aspects of biosurfactants
  • 35.10 Bioremediation using biosurfactants
  • 35.11 Conclusion
  • 35.12 Acknowledgments
  • 35.13 Conflict of interest
  • References
  • Further reading
  • Index

Product details

  • No. of pages: 708
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: March 22, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323851466
  • eBook ISBN: 9780323984171

About the Editors

Inamuddin

Inamuddin is an assistant professor at the Department of Applied Chemistry, Zakir Husain College of Engineering and Technology, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, India. He has extensive research experience in multidisciplinary fields of analytical chemistry, materials chemistry, electrochemistry, renewable energy, and environmental science. He has worked on different research projects funded by various government agencies and universities and is the recipient of awards, including the Fast-Track Young Scientist Award and the Young Researcher of the Year Award 2020 of the university. He has published about 189 research articles in various international scientific journals, 18 book chapters, and 144 edited books with multiple well-known publishers. His current research interests include ion exchange materials, a sensor for heavy metal ions, biofuel cells, supercapacitors, and bending actuators.

Affiliations and Expertise

Assistant Professor, Department of Applied Chemistry, Zakir Husain College of Engineering and Technology, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, India

Charles Adetunji

Charles Oluwaseun Adetunji is an Ag. Director of Intellectual Properties and Technology Transfer as well as an Associate Professor of Microbiology and Biotechnology at the Microbiology Department, Faculty of Science, Edo State University Uzairue, Edo State, Nigeria, where he utilized the application of biological techniques and microbial bioprocesses for the actualization of sustainable development goals. He has won numerous scientific awards and grants from renowned academic bodies, has filled several scientific patents on Bioherbicides, Biopesticides, nanobiosurfactants, and nanobiopesticdes, and has published over 270 scientific journals and conference proceedings in both national and international journals. His broad research interests cover topics relating to food security, agriculture and environmental sustainability, including microbiology, biotechnology, post-harvest management, and nanotechnology. Dr Adetunji is an editorial board member of many international journals serves as a reviewer to many double-blind peer review journals. In addition, he is a member of many scientific organisations and, over the last fifteen years, has built strong working collaborations with reputable research groups in numerous and leading Universities across the globe.

Affiliations and Expertise

Associate Professor, Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo State University Uzairue, Auchi, Edo State, Nigeria

Mohd Ahamed

Dr. Mohd Imran Ahamed is a research associate in the Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh, and he has received his Ph.D on the topic “Synthesis and characterization of inorganic-organic composites heavy metals selective cation-exchangers and their analytical applications” from Aligarh Muslim University India in 2019. He has published several research and review articles in SCI journals. His research focuses on ion-exchange chromatography, wastewater treatment and analysis, actuators, enzymatic biofuel cell, and electrospinning. Dr. Ahamed has published 18 research articles in international journals of repute, more than fifteen book chapters, and 20 published by renowned international publishers.

Affiliations and Expertise

Department of Chemistry, Faculty of Science, Aligarh Muslim University, Aligarh, India

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