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Gradients and Tissue Patterning - 1st Edition - ISBN: 9780128127902, 9780128127919

Gradients and Tissue Patterning, Volume 137

1st Edition

Serial Volume Editors: Stephen Small James Briscoe
Hardcover ISBN: 9780128127902
eBook ISBN: 9780128127919
Imprint: Academic Press
Published Date: 4th March 2020
Page Count: 498
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Table of Contents

1. Lighting up the central dogma for predictive developmental biology
Hernan G. Garcia, Augusto Berrocal, Yang Joon Kim, Gabriella Martini and Jiaxi Zhao
2. Optogenetic approaches to investigate spatiotemporal signaling during development
Katherine W. Rogers and Patrick Müller
3. A matter of time: Formation and interpretation of the Bicoid morphogen gradient
Anqi Huang and Timothy E. Saunders
4. Constraints and limitations on the transcriptional response downstream of the Bicoid morphogen gradient
Huy Tran, Aleksandra M. Walczak and Nathalie Dostatni
5. Formation, interpretation, and regulation of the Drosophila Dorsal/NF-ΚB gradient
Allison E. Schloop, Prasad U. Bandodkar and Gregory T. Reeves
6. The design and logic of terminal patterning in Drosophila
Celia M. Smits and Stanislav Y. Shvartsman
7. Dynamic positional information: Patterning mechanism versus precision in gradient-driven systems
Johannes Jaeger and Berta Verd
8. Intracellular morphogens: Specifying patterns at the subcellular scale
Lars Hubatsch and Nathan W. Goehring
9. Insights into mammalian morphogen dynamics from embryonic stem cell systems
Elena Camacho-Aguilar and Aryeh Warmflash
10. Control of size, fate and time by the Hh morphogen in the eyes of flies
David G. Miguez, Diana Garcia-Morales and Fernando Casares
11. Genetic mechanisms controlling anterior expansion of the central nervous system
Behzad Yaghmaeian Salmani and Stefan Thor
12. Temporal dynamics in the formation and interpretation of Nodal and BMP morphogen gradients
Andrew D. Economou and Caroline S. Hill
13. Signaling regulation during gastrulation: Insights from mouse embryos and in vitro systems
Sophie M. Morgani and Anna-Katerina Hadjantonakis
14. Just passing through: The auxin gradient of the root meristem
Bruno Guillotin and Kenneth D. Birnbaum
15. Small RNAs as plant morphogens
Simon Klesen, Kristine Hill and Marja C.P. Timmermans


Gradients and Tissue Patterning, Volume 137 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Current Topics in Developmental Biology series
  • Includes the latest information on gradients and tissue patterning


Clinicians in the fields of endocrinology, rheumatology, orthopedics, pediatrics and dentistry; basic scientists in anatomy, cell and developmental biology; students and postdoctoral fellows who would like to enter these fields and make further discoveries as well as improve the treatment of major bone-related disorders


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© Academic Press 2020
4th March 2020
Academic Press
Hardcover ISBN:
eBook ISBN:


"For me, this volume marks a substantial shift in the morphogen gradient concept. This has fundamental importance to our understanding of embryonic development and alerts us to the often-overlooked parameter of time in dynamic systems. While this revision has likely been emerging over the last nearly 10 years, it is not easily noticed by one not working directly in the field. Consequently, I appreciate the update this book provides." --Doody

Ratings and Reviews

About the Serial Volume Editors

Stephen Small

Stephen J. Small is at Department of Biology, New York University, NY, USA

Affiliations and Expertise

New York University, NY, USA

James Briscoe

James Briscoe is at The Francis Crick Institute, London, UK

Affiliations and Expertise

The Francis Crick Institute, London, UK