
GPCRs
Structure, Function, and Drug Discovery
Description
Key Features
- Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine
- Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery
- Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology
Readership
Active researchers and students in biochemistry, molecular biology, pharmaceutical science, applied microbiology, and biotechnology; structural biologists, biophysicists; medical chemists; clinician scientists; specialists working in drug development in major health disciplines (cardiology, metabolic disorders, ophthalmology, oncology, neurology, immunology)
Table of Contents
Part I GPCR structure
1. Progress in GPCR structure Determination
2. Structure, function and therapeutic potential of adhesion GPCRs
3. Structural diversity in ligand recognition by GPCRs
4. NMR-based approaches to the study of GPCRs and GPCR-ligand interactions
5. Supramolecular structure of opsins
6. Molecular determinants of GPCR oligomerization
7. Structure of G-protein-coupled receptor heteromers
8. Class A GPCR oligomerization: reasons of controversyPart II GPCR function
9. Quantifying GPCR allostery and biased signaling
10. Kinetics of ligand binding and signaling
11. Allosteric modulators targeting GPCRs
12. Arrestin-mediated signaling at GPCRs
13. Organellar Gbγ signaling - GPCR signaling beyond the cell surfacePart III GPCRs in disease and targeted drug discovery
14. G protein-coupled receptor allosteric modulators: understanding modulator affinity and pharmacological dose
15. Computer-aided GPCR drug discovery
16. Tackling the complexities of orphan GPCR ligand discovery with rationally assisted approaches
17. G protein-coupled receptors in neurodegenerative diseases
18. GPCR targets in type 2 diabetes
19. GPCRs in thromboinflammation and hemostasis
20. Angiotensin II receptors: structure-function and drug discovery
21. GPCRs in innate and adaptive immune responses
22. Role of GPCRs in cancer
Product details
- No. of pages: 500
- Language: English
- Copyright: © Academic Press 2019
- Published: September 11, 2019
- Imprint: Academic Press
- Paperback ISBN: 9780128162286
- eBook ISBN: 9780128167281