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Gonadotropins: From Bench Side to Bedside - 1st Edition - ISBN: 9780128010587, 9780128012666

Gonadotropins: From Bench Side to Bedside, Volume 143

1st Edition

Author: Rajendra Kumar
eBook ISBN: 9780128012666
Hardcover ISBN: 9780128010587
Imprint: Academic Press
Published Date: 1st July 2016
Page Count: 230
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Table of Contents

Chapter One: Mouse Models of Gonadotrope Development

  • Abstract
  • 1. Introduction
  • 2. Signaling Pathways
  • 3. Transcription Factors
  • 4. CRE Mice for Targeting Gonadotropes
  • 5. Concluding Remarks

Chapter Two: Mouse Models for the Study of Synthesis, Secretion, and Action of Pituitary Gonadotropins

  • Abstract
  • 1. Introduction
  • 2. α-Glycoprotein Hormone Subunit
  • 3. LHβ Subunit
  • 4. FSHβ Subunit
  • 5. Transforming Growth Factor-β Superfamily Members and Gonadotropins
  • 6. Other Mouse Models
  • 7. Conclusions and Future Directions
  • Acknowledgments

Chapter Three: Clinical Applications of Gonadotropins in the Female: Assisted Reproduction and Beyond

  • Abstract
  • 1. Introduction
  • 2. Molecular Biology of the Ovarian Response
  • 3. Gonadotropins in Assisted Reproduction
  • 4. Ovarian Stimulation Protocols in ART
  • 5. Adverse Events in Ovarian Stimulation
  • 6. Gonadotropins Beyond ART
  • 7. Conclusions
  • Acknowledgments

Chapter Four: Clinical Applications of Gonadotropins in the Male

  • Abstract
  • 1. Introduction
  • 2. Structural Features of the Gonadotropins
  • 3. Regulation of the Synthesis and Secretion of the Pituitary Gonadotropins
  • 4. Gonadotropin Secretion
  • 5. Pharmacokinetics of Gonadotropins
  • 6. Gonadotropin Formulations Available for Treating Hypogonadotropic Hypogonadism and Infertility in Men
  • 7. Treatment with Gonadotropins in the Male
  • 8. Concluding Remarks
  • Acknowledgments

Chapter Five: Beyond Reproduction: Pituitary Hormone Actions on Bone

  • Abstract
  • 1. Evolutionary Considerations
  • 2. Epidemiology Suggests an FSH–Bone Connection
  • 3. FSH Directly Affects the Skeleton
  • 4. FSH Signals Through FSHRs on Bone Cells
  • 5. FSH Antibody Rescues Hypogonadal Bone Loss
  • 6. Oxytocin is Anabolic to Bone
  • 7. Oxytocin and Skeletal Regulation During Reproduction
  • 8. Prolactin and Bone

Chapter Six: Gonadotrope Tumors

  • Abstract
  • 1. Introduction
  • 2. Gonadotropes in the Normal Pituitary
  • 3. Gonadotrope Hyperplasia
  • 4. Gonadotrope Tumors
  • 5. Conclusions


Gonadotropins: From Bench Side to Bedside, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on all aspects of gonadotropins, from research to treatment.

Key Features

  • Contains contributions from leading authorities on the topic
  • Publishes cutting-edge reviews in molecular biology
  • Informs and updates on all the latest developments available regarding the research of gonadotropins


Students, researchers, microbiologists, molecular biologists


No. of pages:
© Academic Press 2016
1st July 2016
Academic Press
eBook ISBN:
Hardcover ISBN:


Praise for the Series:
"Maintains the tradition and set-up of the previous volumes and certainly provides up-to-date data on varied aspects of cytology... a valuable acquisition to any library." --The Nucleus

Ratings and Reviews

About the Author

Rajendra Kumar

Professor T. Rajendra Kumar works at the Department of Obstetrics & Gynecology, University of Colorado Denver.

Affiliations and Expertise

Department of Obstetrics & Gynecology, University of Colorado Denver, Aurora, CO, USA