This volume summarizes the evolution and physiology of GnRH molecules and receptors, and provides insight as to how social behavior influences cellular and molecular events in the brain from a comparative perspective.

The chapters in this volume are divided into three major sections: Development and Cell Migration, GnRH Receptors, Physiology and Regulation. The review papers arose primarily from presentations made at the Second International Symposium on the Comparative Biology of GnRH, held in Penang, Malaysia, June 2-4, 2001; a satellite symposium in conjunction with the XIV International Congress of Comparative Endocrinology, Sorrento, Italy. In addition, leading neuroscientists doing cutting-edge research in the field of GnRH were invited as authors to make this volume a valuable reference.

Table of Contents

List of contributors. Preface. 1. Development and Cell Migration. Cell migration and evolutionary significance of GnRH subtypes (I.S. Parhar). GnRH in the invertebrates: an overview (R.K. Rastogi et al.). Structural and chemical guidance cues for the migration of GnRH neurons in the chick embryo (S. Murakami et al.). What defines the Nervus Terminalis? Neurochemical, developmental and anatomical criteria (C.R. Wirsig-Wiechmann et al.). Angiogenesis in association with the migration of gonadotropic hormone-releasing hormone (GnRH) systems in embryonic mice, early human embryos and in a fetus with Kallmann Syndrome (M.Schwanzel-Fukuda, D.W. Pfaff). Recent advances in the pathogenesis of Kallmann's syndrome (P.-M. Bouloux et al.). 2. GnRH Receptors. Differences in structure-function relations between non mammalian and mammalian GnRH receptors: what we have learnt from the African catfish GnRH receptor (M. Blomenröhr et al.). Regulation of GnRH and its receptor in a teleost, red seabream (K. Okuzawa et al.). Multiplicity of gonadotropin-releasing hormone signaling: a comparative perspective (C. Klausen et al.). Gonadotropin-releasing hormone receptor: cloning, expression and transcriptional regulation (S.S. Kakar et al.). 3. Physiology and Regulation. Hypothalamic control of gonadotropin secretion (S.M. McCann et al.). Gonadotropin-releasing hormone (GnRH) surge generator in female rats (T. Funabashi et al.). Mechanisms of inhibition of LHRH release by alcohol and cannabinoids (V. Rettori et al.). Glutamatergic regulation of gonadotropin releasing hormone neurons (L. Jennes et al.). Gonadotropin-releasing hormone (GnRH) neurons: gene expression and neuroanatomical studies (A.C. Gore). GnRH pre-mRNA splicing: role of exonic splicing enhancer (J. Han et al.).


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© 2002
Elsevier Science
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About the editor

I.S. Parhar

Affiliations and Expertise

Department of Physiology, Nippon Medical School, Tokyo, Japan