1st Edition - August 11, 2017

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  • Editors: Trenton Schoeb, Kathryn Eaton
  • eBook ISBN: 9780128045831
  • Hardcover ISBN: 9780128045619

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Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource.

Key Features

  • Reviews and defines gnotobiotic animal species
  • Analyzes microbiota in numerous contexts
  • Presents detailed coverage of the protocols and operation of a gnotobiotic facility


Researchers, postdoctoral fellows, graduate students, research technicians, laboratory animal veterinarians, animal care personnel, and administrators in both academia and industry with an interest in microbiota/microbiome related research and/or gnotobiotic facility establishment and operation

Table of Contents

  • 1. Historical Overview
    2. Principles of Establishing and Operating a Gnotobiotic Facility
    3. Procedures for Rodents
    4. Developing a Business Plan for a Gnotobiotics Program
    5. Gnotobiotic Pigs: From Establishing a Facility to Modeling Human Infectious Diseases
    6. Gnotobiotic Fish as Models to Study Host-Microbe Interactions
    7. Use of Gnotobiotic Mice in the Study of Metabolic Syndrome
    8. Gnotobiotics and Inflammatory Bowel Disease

Product details

  • No. of pages: 428
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: August 11, 2017
  • Imprint: Academic Press
  • eBook ISBN: 9780128045831
  • Hardcover ISBN: 9780128045619

About the Editors

Trenton Schoeb

Dr Trenton Schoeb’s research focuses on gnotobiotic and specific pathogen-free (SPF) rodents and the phenotyping of mutant mice. He has participated in a wide variety of projects involving evaluation of disease expression in rodents and other species. His current interests are in development of gnotobiotic mouse models of inflammatory bowel disease and identification of specific intestinal bacteria involved in initiation and/or perpetuation of intestinal inflammation in these models.

Affiliations and Expertise

Department of Genetics (Genomics Division) and Animal Resources Program Comparative Pathology Laboratory, University of Alabama at Birmingham

Kathryn Eaton

Dr. Kathryn Eaton is a board-certified veterinary pathologist (diplomate of the American College of Veterinary Pathologists) with research interests in bacterial pathogens of the gastrointestinal tract, host-pathogen interactions, and intestinal immunity.

Affiliations and Expertise

Department of Microbiology and Immunology, University of Michigan Medical School

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