Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals.
In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource.
- Reviews and defines gnotobiotic animal species
- Analyzes microbiota in numerous contexts
- Presents detailed coverage of the protocols and operation of a gnotobiotic facility
Researchers, postdoctoral fellows, graduate students, research technicians, laboratory animal veterinarians, animal care personnel, and administrators in both academia and industry with an interest in microbiota/microbiome related research and/or gnotobiotic facility establishment and operation
1. Historical Overview
2. Principles of Establishing and Operating a Gnotobiotic Facility
3. Procedures for Rodents
4. Developing a Business Plan for a Gnotobiotics Program
5. Gnotobiotic Pigs: From Establishing a Facility to Modeling Human Infectious Diseases
6. Gnotobiotic Fish as Models to Study Host-Microbe Interactions
7. Use of Gnotobiotic Mice in the Study of Metabolic Syndrome
8. Gnotobiotics and Inflammatory Bowel Disease
- No. of pages:
- © Academic Press 2017
- 15th August 2017
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Dr Trenton Schoeb’s research focuses on gnotobiotic and specific pathogen-free (SPF) rodents and the phenotyping of mutant mice. He has participated in a wide variety of projects involving evaluation of disease expression in rodents and other species. His current interests are in development of gnotobiotic mouse models of inflammatory bowel disease and identification of specific intestinal bacteria involved in initiation and/or perpetuation of intestinal inflammation in these models.
Department of Genetics (Genomics Division) and Animal Resources Program Comparative Pathology Laboratory, University of Alabama at Birmingham
Dr. Kathryn Eaton is a board-certified veterinary pathologist (diplomate of the American College of Veterinary Pathologists) with research interests in bacterial pathogens of the gastrointestinal tract, host-pathogen interactions, and intestinal immunity.
Department of Microbiology and Immunology, University of Michigan Medical School