Glycosylation and Cancer
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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
Key Features
- Provides information on cancer research
- Outstanding and original reviews
- Suitable for researchers and students
Readership
Researchers working in any area related to extracellular matrix function, the epithelial-to-mesenchymal transition and the mechanisms of metastasis.
Table of Contents
- Preface
- Chapter One: Glycosylation and Cancer: Moving Glycomics to the Forefront
- Abstract
- 1 Introduction
- 2 Contributions to the Volume
- 3 Opportunities and Challenges
- 4 Emerging Areas
- Chapter Two: Glycans and Cancer: Role of N-Glycans in Cancer Biomarker, Progression and Metastasis, and Therapeutics
- Abstract
- 1 Introduction
- 2 Metabolic Pathway of Branched N-Glycans and Their Corresponding Glycosyltransferases
- 3 Future Perspectives
- Acknowledgments
- Chapter Three: Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer
- Abstract
- 1 Introduction
- 2 O-glycan Biosynthesis
- 3 Altered O-Glycan Structures Observed in Cancer
- 4 Clinical Applications
- 5 Conclusions
- Acknowledgments
- Chapter Four: Intracellular Protein O-GlcNAc Modification Integrates Nutrient Status with Transcriptional and Metabolic Regulation
- Abstract
- 1 O-GlcNAc Modification: An Overview
- 2 Hyper O-GlcNAc Modification Observed in Human Tumors
- 3 O-GlcNAc Transferase: Structure, Activity, and Regulation
- 4 O-GlcNAcase: Structure and Function
- 5 The Hexosamine Biosynthetic Pathway
- 6 Effects of O-GlcNAc Modification on Epigenetic Regulation
- 7 Anticancer Effects of Reducing Hyper-O-GlcNAcylation in Cancer Cells
- 8 Effects of O-GlcNAc Cycling Enzymes on Glucose Homeostasis and Metabolism
- 9 Detection of O-GlcNAcylated Proteins
- 10 Conclusions
- Chapter Five: The Detection and Discovery of Glycan Motifs in Biological Samples Using Lectins and Antibodies: New Methods and Opportunities
- Abstract
- 1 Introduction
- 2 Ways to Use GBPs for Probing Glycan Motifs
- 3 Defining the Fine Specificities of GBPs from Glycan Array Data
- 4 Higher Order Influences on GBP Binding: Density, Location, and Accessibility
- 5 Quantitative Interpretation of GBP Measurements
- 6 Finding the Right Reagent: Mining Glycan Array Data, Engineering GBPs, and Creating Antibodies
- 7 Discovering Glycan Motifs Using GBPs: Application to Cancer Biomarkers
- 8 Conclusions and Prospects
- Chapter Six: Glycosylation Characteristics of Colorectal Cancer
- Abstract
- 1 Introduction
- 2 Changes of Cellular and Tissue Glycosylation in CRC
- 3 Serum-Related Glycosylation Changes in CRC
- 4 Biological Relevance of Glycan in CRC
- 5 Analysis of Glycans: Useful Techniques for Glycomics
- 6 Conclusion and Future Perspectives
- Acknowledgment
- Chapter Seven: Glycosylation and Liver Cancer
- Abstract
- 1 Hepatocellular Carcinoma
- 2 Hepatitis: A Major Risk Factor for HCC
- 3 Proteomic Identification of Biomarkers of Liver Cancer
- 4 Glycomic Methodologies for the Identification of Biomarkers of Liver Cancer
- 5 Fucosylation is Not Universally Increased in HCC Tissue as Compared to Adjacent or Control Tissue
- 6 Increased Branching is Observed in HCC Tissue
- 7 Effect of Glycosylation on Hepatocyte Growth
- 8 Conclusion
- Chapter Eight: Functional Impact of Tumor-Specific N-Linked Glycan Changes in Breast and Ovarian Cancers
- Abstract
- 1 Introduction
- 2 N-Linked Glycans
- 3 Concluding Remarks
- Acknowledgments
- Chapter Nine: Glycosylation Alterations in Lung and Brain Cancer
- Abstract
- 1 Introduction
- 2 N-Linked Glycans
- 3 O-Linked Glycans
- 4 Mucins
- 5 Sialic Acid
- 6 Fucosylation
- 7 Heparan Sulfate Proteoglycans and Their Modifying Enzymes
- 8 Clinical Significance
- Chapter Ten: Altered Glycosylation in Prostate Cancer
- Abstract
- 1 Introduction
- 2 Current Glycoprotein Biomarkers of Prostate Cancer
- 3 N-Linked Glycosylation in Prostate Tissues
- 4 N-Linked Glycosylation in Prostate Cancer Proximal Biofluids and Exosomes
- 5 Glycosylation in Prostate Cancer Cell Lines
- 6 O-Linked Glycosylation in Prostate Cancer
- 7 Glycolipids in Prostate Cancer
- 8 Summary
- Index
Product details
- No. of pages: 418
- Language: English
- Copyright: © Academic Press 2015
- Published: February 26, 2015
- Imprint: Academic Press
- eBook ISBN: 9780128016145
- Hardcover ISBN: 9780128013816
About the Serial Volume Editors
Richard Drake
Dr. Drake is a Professor in the Department of Cell and Molecular Pharmacology and Experimental Therapeutics at the Medical University of South Carolina and SmartState Endowed Chair in Proteomics. He is an experienced protein biochemist and glycobiologist, with particular expertise in tumor biology and biomarker discovery from clinical fluids and tissues related to urological cancers and other cancers. He obtained his Ph.D. in Biochemistry at the University of Kentucky with Boyd Haley, generating multiple nucleotide sugar photoaffinity analogs for use in the study of glycosyltransferases. More extensive glycobiology training was done in post-doctoral work with Alan Elbein, and he began his academic career in Dr. Elbein’s department at the University of Arkansas for Medical Sciences. Currently, his research focus is on direct analysis of glycans and glycolipids in tissues using state-of-the-art MALDI mass spectrometry imaging approaches. Complementary glycopeptide mass spectrometry and metabolic labeling targeted approaches are being done to identify specific glycoproteins involved in the epithelial-to-mesenchymal transition.
Affiliations and Expertise
Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, USA
Lauren Ball
Affiliations and Expertise
Cell and Molecular Pharmacolgy & Experimental Therapeutics, Medical University of South Carolina,USA