Glycosylation and Cancer, Volume 126

• Preface
• Chapter One: Glycosylation and Cancer: Moving Glycomics to the Forefront
  • Abstract
  • 1 Introduction
  • 2 Contributions to the Volume
  • 3 Opportunities and Challenges
  • 4 Emerging Areas
• Chapter Two: Glycans and Cancer: Role of N-Glycans in Cancer Biomarker, Progression and Metastasis, and Therapeutics
  • Abstract
  • 1 Introduction
  • 2 Metabolic Pathway of Branched N-Glycans and Their Corresponding Glycosyltransferases
  • 3 Future Perspectives
  • Acknowledgments
• Chapter Three: Simple Sugars to Complex Disease—Mucin-Type O-Glycans in Cancer
  • Abstract
  • 1 Introduction
  • 2 O-glycan Biosynthesis
  • 3 Altered O-Glycan Structures Observed in Cancer
  • 4 Clinical Applications
  • 5 Conclusions
  • Acknowledgments
• Chapter Four: Intracellular Protein O-GlcNAc Modification Integrates Nutrient Status with Transcriptional and Metabolic Regulation
  • Abstract
  • 1 O-GlcNAc Modification: An Overview
  • 2 Hyper O-GlcNAc Modification Observed in Human Tumors
  • 3 O-GlcNAc Transferase: Structure, Activity, and Regulation
  • 4 O-GlcNAcase: Structure and Function
  • 5 The Hexosamine Biosynthetic Pathway
  • 6 Effects of O-GlcNAc Modification on Epigenetic Regulation
  • 7 Anticancer Effects of Reducing Hyper-O-GlcNAcylation in Cancer Cells
  • 8 Effects of O-GlcNAc Cycling Enzymes on Glucose Homeostasis and Metabolism
  • 9 Detection of O-GlcNAcylated Proteins
  • 10 Conclusions
• Chapter Five: The Detection and Discovery of Glycan Motifs in Biological Samples Using Lectins and Antibodies: New Methods and Opportunities
  • Abstract
  • 1 Introduction
  • 2 Ways to Use GBPs for Probing Glycan Motifs
  • 3 Defining the Fine Specificities of GBPs from Glycan Array Data
  • 4 Higher Order Influences on GBP Binding: Density, Location, and Accessibility
  • 5 Quantitative Interpretation of GBP Measurements
  • 6 Finding the Right Reagent: Mining Glycan Array Data, Engineering GBPs, and Creating Antibodies
  • 7 Discovering Glycan Motifs Using GBPs: Application to Cancer Biomarkers
  • 8 Conclusions and Prospects
• Chapter Six: Glycosylation Characteristics of Colorectal Cancer
  • Abstract
  • 1 Introduction
  • 2 Changes of Cellular and Tissue Glycosylation in CRC
  • 3 Serum-Related Glycosylation Changes in CRC
  • 4 Biological Relevance of Glycan in CRC
  • 5 Analysis of Glycans: Useful Techniques for Glycomics
  • 6 Conclusion and Future Perspectives
  • Acknowledgment
• Chapter Seven: Glycosylation and Liver Cancer
  • Abstract
  • 1 Hepatocellular Carcinoma
  • 2 Hepatitis: A Major Risk Factor for HCC
  • 3 Proteomic Identification of Biomarkers of Liver Cancer
  • 4 Glycomic Methodologies for the Identification of Biomarkers of Liver Cancer
  • 5 Fucosylation is Not Universally Increased in HCC Tissue as Compared to Adjacent or Control Tissue
  • 6 Increased Branching is Observed in HCC Tissue
  • 7 Effect of Glycosylation on Hepatocyte Growth
  • 8 Conclusion
• Chapter Eight: Functional Impact of Tumor-Specific N-Linked Glycan Changes in Breast and Ovarian Cancers
  • Abstract
  • 1 Introduction
  • 2 N-Linked Glycans
  • 3 Concluding Remarks
  • Acknowledgments
• Chapter Nine: Glycosylation Alterations in Lung and Brain Cancer
  • Abstract
  • 1 Introduction
  • 2 N-Linked Glycans
  • 3 O-Linked Glycans
  • 4 Mucins
  • 5 Sialic Acid
  • 6 Fucosylation
  • 7 Heparan Sulfate Proteoglycans and Their Modifying Enzymes
  • 8 Clinical Significance
• Chapter Ten: Altered Glycosylation in Prostate Cancer
  • Abstract
  • 1 Introduction
  • 2 Current Glycoprotein Biomarkers of Prostate Cancer
  • 3 N-Linked Glycosylation in Prostate Tissues
  • 4 N-Linked Glycosylation in Prostate Cancer Proximal Biofluids and Exosomes
  • 5 Glycosylation in Prostate Cancer Cell Lines
  • 6 O-Linked Glycosylation in Prostate Cancer
  • 7 Glycolipids in Prostate Cancer
  • 8 Summary
• Index

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Researchers working in any area related to extracellular matrix function, the epithelial-to-mesenchymal transition and the mechanisms of metastasis.