Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions

1st Edition - February 1, 2023

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  • Editors: Rita Ferreira, Pedro Oliveira, Rita Nogueira-Ferreira
  • Paperback ISBN: 9780323917049

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Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research. Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis.

Key Features

  • Features chapter contributions from international leaders in the field
  • Spans fundamental aspects of glycolysis, patho-physiology and drug discovery
  • Includes step-by-step instruction in a range of research protocols, ranging from Omics to interactive analysis and measuring glycolysis flux


Researchers in Biochemistry, Pharmacology, Medicinal Chemistry, Physiology, Pathology, and Translational Medicine, Students and clinicians

Table of Contents

    1. Development and glycolysis dependence
    2. Neuro-glia communication and glycolysis
    3. Glycolysis and skeletal muscle plasticity
    4. Glycolysis and trained heart
    5. Bone glycolysis and the regulation of energy balance
    6. Glycolysis in adipose tissue-dependent thermogenesis
    7. Regulation of glycolysis from a liver-centric perspective
    8. Glycolysis as a rheostat mechanism in pancreas function
    9. The Warburg-like effect in reproductive events

    10. Exploring glycolytic adaptations in cancer cells
    11. The glycolytic pathway to heart failure
    12. Glycolysis in PAH and COPD metabolic reprogramming
    13. Glycolysis and mitochondrial function in diabetes mellitus
    14. Metabolic adaptation to glycolysis as a basic defense mechanism of immune cells
    15. Inborn glycolytic pathway defects
    16. Enhanced glycolysis and metabolic complications of hematologic malignancies
    17. Implications of glycolysis for osteoporosis pathogenesis
    18. Glucose, glycolysis, and neurodegenerative diseases
    19. Viral Infections and glycolysis

    SUPPLEMENTAL INFORMATION – Methodological approaches
    20. The application of Omics to explore glycolysis
    21. An interactive analysis of glycolysis regulation
    22. Measuring glycolysis flux

Product details

  • Language: English
  • Copyright: © Academic Press 2023
  • Published: February 1, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780323917049

About the Editors

Rita Ferreira

Rita Ferreira has a degree and a PhD in Biochemistry. RF is Assistant Professor at University of Aveiro where she has been teaching courses related to biochemistry and biomedicine to both undergraduate and graduate students. RF develops research work in the field of muscle plasticity in pathophysiological conditions, including the evaluation of the impact of exercise training in cancer-induced muscle wasting using Omics approaches. She is particularly interested in the study of the preventive and therapeutic effect of physical activity in the setting of wasting conditions.

Affiliations and Expertise

Assistant Professor, Department of Chemistry, University of Aveiro, Aveiro, Portugal

Pedro Oliveira

Dr. Pedro Fontes Oliveira, in 2004, earned his PhD degree in Biomedical Sciences, at the University of Porto, Portugal. In 2005, Pedro F. Oliveira started his post-doctoral fellowship at the University of Porto and began working on a new line of research now focused on reproductive biology, specifically in Sertoli cells ionic regulation. In 2009, Dr. Oliveira was selected to apply for the “Ciência 2008 Program” through the Health Science Research Center, University of Beira Interior (CICS-UBI) and was hired as an Assistant Researcher. Currently Dr. Oliveira's research interests include hormonal control and metabolic modulation of spermatogenesis, with emphasis on Sertoli cells hormonal modulation, ionic water transport, and mechanisms by which endocrine disorders and pathologies, namely Diabetes Mellitus, result in subfertility and infertility.

Affiliations and Expertise

Assistant Professor, Department of Chemistry, University of Aveiro, Aveiro, Portugal

Rita Nogueira-Ferreira

Rita Nogueira Ferreira has a graduation in Biochemistry (2010), a master's degree in Biochemistry – specialization in Clinical Biochemistry (2012), and a PhD in Biochemistry (2017), obtained at the University of Aveiro (Portugal). She has been developing research work in the study of the molecular and cellular mechanisms associated with different pathological conditions (pulmonary arterial hypertension, heart failure, cancer, obesity) and related to the effect of pharmacological and non-pharmacological approaches (exercise training) in the prevention or treatment of these conditions, using proteomic approaches. Currently, she works as Junior Researcher at UnIC@RISE, Department of Surgery and Physiology from the Faculty of Medicine of the University of Porto, Portugal. She was awarded in the FCT Individual Call to Scientific Employment Stimulus (CEECIND) 2021 to proceed in the study of sexual dimorphism in cardiovascular pathophysiology. In particular, she is interested in exploring the sex differences in heart failure, as well as the adaptations to exercise training, aiming to improve heart failure management.

Affiliations and Expertise

UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal

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